Endocrinology — Flashcards

Thyroid, Pituitary, & Adrenal _____ stimulates the liver to produce IGF-1

High levels of _____ inhibit organification of I2, and therefore inhibit synthesis of thyroid hormones (Wolff-Chaikoff effect)

One major effect of thyroid hormone is increased _____ with a resultant increase in BMR and body temperature, due to increased Na/K+-ATPase activity

Parathyroid hormone is secreted in response to decreased plasma _____ and 1,25-(OH)2 D3

In bone, PTH receptors are located on _____, but not on osteoclasts

Activation of _____ adrenergic receptors on pancreatic islet cells causes decreased insulin release

Initially and transiently, PTH causes an increase in bone _____ by a direct action on osteoblasts

Glucocorticoids _____ glucose utilization by tissues and decrease insulin sensitivity of adipose tissue

The effects of cortisol may be remembered with the mnemonic "A BIG FIB": A: _____B: Blood pressure (increased, via alpha1)I: Insulin resistance (increased)G: Gluconeogenesis (increased)F: Fibroblast activity (decreased)I: Inflammatory/Immune response (decreased)B: Bone formation (decreased)

Glucagon-like peptide-1 (GLP-1) stimulates _____ secretion and inhibits glucagon secretion