Blood and Immunity — Flashcards

Flashcard 41: Plasma constitutes _____% of blood volume, while RBCs constitute the remaining 45%

Answer: 55

Flashcard 42: The CD34+ hematopoietic stem cell may differentiate into a _____ or lymphoid stem cell

Answer: myeloid

Flashcard 43: Eosinophils produce compounds that deal with parasites, including major basic protein, _____ and arylsulfatase B

Answer: histaminase

Flashcard 44: _____ O2 binding to hemoglobin causes increased affinity for CO2 and H+ (Haldane effect)

Answer: Decreased

Flashcard 45: The coagulation cascade generates _____, which converts fibrinogen in the platelet plug to fibrin (factor Ia). *BnB expansion: Which 4 factors does thrombin activate (positive feedback)?

Answer: thrombin (factor IIa)

Extra: Thrombin (Factor IIa) pro-coagulant roles: 1. Converts Fibrinogen (I) to Fibrin (Ia). 2. Positive feedback: Activates factors V, VIII, XI. 3. Factor XIII activation (to cross-link fibrin). 4. Platelet activation.

Flashcard 46: Endothelial cells prevent thrombosis by producing _____, which redirects thrombin to activate protein C

Answer: thrombomodulin

Flashcard 47: Decreased hemoglobin (e.g. anemia) is associated with _____ SaO2, decreased O2 content, and normal PaO2

Answer: normal

Flashcard 48: Primary hemostasis is mediated by interactions between _____ and the vessel wall

Answer: platelets

Flashcard 49: A normal WBC count is approximately _____ - 11,000/µL

Answer: 4,000

Flashcard 50: One source of von Willebrand factor (vWF) is from the _____ granules of platelets

Answer: alpha