Blood and Immunity — Flashcards

Flashcard 41: Factors that shift the O2-Hb dissociation curve to the _____ favor the taut form of hemoglobin

Answer: right

Flashcard 42: _____ on endothelial cells bind Sialyl-LewisX on leukocytes, resulting in rolling of leukocytes along the vessel wall

Answer: Selectins

Flashcard 43: Primary hemostasis is mediated by interactions between _____ and the vessel wall

Answer: platelets

Flashcard 44: The coagulation cascade generates _____, which converts fibrinogen in the platelet plug to fibrin (factor Ia). *BnB expansion: Which 4 factors does thrombin activate (positive feedback)?

Answer: thrombin (factor IIa)

Extra: Thrombin (Factor IIa) pro-coagulant roles: 1. Converts Fibrinogen (I) to Fibrin (Ia). 2. Positive feedback: Activates factors V, VIII, XI. 3. Factor XIII activation (to cross-link fibrin). 4. Platelet activation.

Flashcard 45: A normal WBC count is approximately _____ - 11,000/µL

Answer: 4,000

Flashcard 46: Endothelial cells prevent thrombosis by producing _____, which redirects thrombin to activate protein C

Answer: thrombomodulin

Flashcard 47: _____ O2 binding to hemoglobin causes increased affinity for CO2 and H+ (Haldane effect)

Answer: Decreased

Flashcard 48: Eosinophils produce compounds that deal with parasites, including major basic protein, _____ and arylsulfatase B

Answer: histaminase

Flashcard 49: Decreased hemoglobin (e.g. anemia) is associated with _____ SaO2, decreased O2 content, and normal PaO2

Answer: normal

Flashcard 50: The transcobalamin II-B12 complex is transported to the _____ (hematopoiesis) and liver (storage)

Answer: bone marrow