Coagulation and Fibrinolysis — Flashcards

Flashcard 1: _____ activates factor VII, which initiates the extrinsic pathway of the coagulation cascade

Answer: Tissue thromboplastin

Flashcard 2: In the first step of fibrinolysis, _____ is converted to plasmin via tissue plasminogen activator (tPA)

Answer: plasminogen

Flashcard 3: The coagulation cascade generates _____, which converts fibrinogen in the platelet plug to fibrin (factor Ia). *BnB expansion: Which 4 factors does thrombin activate (positive feedback)?

Answer: thrombin (factor IIa)

Extra: Thrombin (Factor IIa) pro-coagulant roles: 1. Converts Fibrinogen (I) to Fibrin (Ia). 2. Positive feedback: Activates factors V, VIII, XI. 3. Factor XIII activation (to cross-link fibrin). 4. Platelet activation.

Flashcard 4: Factor X of the coagulation cascade may be activated by factor _____ with factor VIII as a cofactor (intrinsic pathway)

Answer: IX

Flashcard 5: Bleeding time is normally between _____ and 7 minutes

Answer: 2

Flashcard 6: Which blood type does not have any group antigens on RBC surfaces?

Answer: Type O

Flashcard 7: What unique antibodies in plasma do patients with the A blood type have? _____

Answer: Anti-B (IgM)

Flashcard 8: What is the formula for calculating Blood volume from Plasma volume and hematocrit?

Answer: Blood volume = Plasma volume / (1 - Hematocrit)

Flashcard 9: Patients with the B blood type cannot receive which blood types?

Answer: A and AB

Flashcard 10: oral polio vaccine produces _____ immunity

Answer: humoral and local

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