Reproductive Pathology Indian Medical PG Flashcards - Medical Study Cards
Master Reproductive Pathology with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Reproductive Pathology Flashcard Deck - 98 Cards
Flashcard 1: The following image represents the _____ carcinoma subtype of invasive ductal carcinoma:
Answer: tubular
Flashcard 2: The H&E stained specimen shows endometrial glands and surrounding stroma in myometrium, suggestive of _____
Answer: Adenomyosis
Flashcard 3: In regards to cervical epithelium, if the tissue sample on the left is normal, is the tissue sample on the right: mildly dysplastic, moderately dysplastic, or severely dysplastic / carcinoma in situ?
_____
VS
Answer: Severely Dysplastic / Carcinoma in Situ
Flashcard 4: A dysgerminoma is an ovarian germ cell tumor composed of large primitive "oocyte-like" cells with clear cytoplasm and central nuclei; described as "_____" cells
Answer: fried egg
Flashcard 5: Ovarian _____ cystadenoma is a large, multiloculated benign tumor lined by mucus-secreting epithelium
Answer: mucinous
Flashcard 6: Breast Cancer Assessment: The following is an immunohistochemical stain for the _____ receptor, which is located in nuclei
Answer: estrogen
Flashcard 7: The histology image shows a whorled pattern of smooth muscle bundles with well-dermarcated borders, which is characteristic of _____
Answer: leiomyoma (fibroid)
Flashcard 8: In regards to cervical epithelium, if the tissue sample on the left is normal, is the tissue sample on the right: mildly dysplastic, moderately dysplastic, or severely dysplastic / carcinoma in situ?
_____
VS
Answer: Moderately Dysplastic
Flashcard 9: Is this histology of this Cervical Epithelium normal, mildly dysplastic, moderately dysplastic, or severe dysplasia / carcinoma in situ?
_____
Answer: Normal
Flashcard 10: _____ is a testicular germ cell tumor that forms a homogenous mass with no hemorrhage or necrosis
Answer: Seminoma
Flashcard 11: The histology image below has lymphocytes and plasma cells in the endometrium, which is indicative of _____
Answer: chronic endometritis
Flashcard 12: The image shows _____ bodies which are seen in Granulosa cell tumour.
Answer: Call exner
Flashcard 13: _____ is a testicular germ cell tumor that forms a hemorrhagic mass with necrosis
Answer: Embryonal carcinoma
Flashcard 14: The gross appearance of inflammatory breast cancer is often described as resembling an _____ (due to invasion of lymphatic spaces)
Answer: orange peel (Peau d'orange)
Flashcard 15: _____ is a malignant testicular tumor comprised of large cells with clear cytoplasm and central nuclei, sometimes described as a "fried egg" appearance
Answer: Seminoma
Flashcard 16: Powder burn spots over the peritoneum are seen in _____.
Answer: endometriosis
Flashcard 17: Small _____philic colloid amyloid bodies called corpora amylacea are frequently seen within a prostatic follicle.
Answer: eosino
Flashcard 18: _____ emboli are characterized by squamous cells and keratin debris in the embolus
Answer: Amniotic fluid
Flashcard 19: _____ are the most common changes in pre-menopausal breast
Answer: Fibrocystic changes
Flashcard 20: The Gleason grading system (for prostatic adenocarcinoma) is based on _____, not nuclear atypia
Answer: architecture
Flashcard 21: The two most common subtypes of ovarian surface epithelial tumors are _____ and mucinous; both usually cystic
Answer: serous
Flashcard 22: _____ is an abnormal conception characterized by swollen and edematous chorionic villi with proliferation of trophoblasts only
Answer: Hydatidiform mole
Flashcard 23: An intraductal papilloma is a proliferation of papillary cells that develop in _____ or cyst wall with a fibrovascular core
Answer: ducts
Flashcard 24: Endometrial carcinoma from the _____ pathway has a serous, papillary histology
Answer: sporadic
Flashcard 25: Choriocarcinoma is a small, hemorrhagic tumor with early, diffuse _____ spread, especially to the lungs
Answer: hematogenous
Flashcard 26: Testicular germ cell tumors often present as a _____ germ cell tumor; prognosis is based on the worst component
Answer: mixed
Flashcard 27: Endometrial hyperplasia is classified histologically based on _____ (simple or complex) and the presence or absence of cellular atypia
Answer: architectural growth pattern
Flashcard 28: In _____ syndrome a person is genotypically XY but has female external genitalia with male internal gonads
Answer: androgen insensitivity
Flashcard 29: Endometrial carcinoma from the _____ pathway has an endometrioid histology
Answer: hyperplasia
Flashcard 30: Tubular carcinoma can be differentiated from normal breast tissue by lack of _____ cells and presence of desmoplastic stroma
Answer: myoepithelial
Flashcard 31: Grade _____ endometrial CA: some glands show the papillary pattern and are solid
Answer: 2
Flashcard 32: _____ crystals are seen in Hilus cell tumor of the ovary
Answer: Reinke's
Flashcard 33: _____ is a small papillary proliferation within lactiferous ducts, typically beneath the areola of the breast
Answer: Intraductal papilloma
Flashcard 34: _____ degeneration of epididymis can result in epididymal cysts.
Answer: Cystic
Flashcard 35: _____ is a cystic teratoma composed primarily of thyroid tissue and thus may cause hyperthyroidism
Answer: Struma ovarii
Flashcard 36: In the _____ pathway (75%) of endometrial carcinoma, the carcinoma arises from endometrial hyperplasia
Answer: hyperplasia
Flashcard 37: One precursor lesion of _____ is Erythroplasia of Queyrat, which is the in situ carcinoma of the glans of the penis that presents as erythroplakia
Answer: penile SCC
Flashcard 38: Chronic endometritis is characterized by _____ and plasma cells in the endometrium
Answer: lymphocytes
Flashcard 39: One precursor lesion of _____ is Bowen disease, which is the in situ carcinoma of the penile shaft or scrotum that presents as leukoplakia
Answer: penile SCC
Flashcard 40: One type of a rare ovarian surface epithelial tumor is a _____ tumor, which is composed of bladder-like epithelium (urothelium)
Answer: Brenner
Flashcard 41: _____ is an increase in acini (ducts) and stromal fibrosis of breast tissue, which may be seen as calcifications on mammogram
Answer: Sclerosing adenosis
Flashcard 42: Breast Cancer Assessment: The following is an immunohistochemical stain for the _____ receptor, which is located in nuclei
Answer: estrogen
Flashcard 43: Prostatic adenocarcinoma is CK 7 _____ and CK 20 negative
Answer: negative
Flashcard 44: Choriocarcinoma that arises as a _____ has a poor response to chemotherapy
Answer: spontaneous germ cell tumor
Flashcard 45: _____ tumor is a sex cord-stromal tumor associated with characteristic Reinke crystals (eosinophilic cytoplasmic inclusion) on histology
Answer: Leydig cell
Flashcard 46: _____ cystadenoma is a benign tumor lined with fallopian tube-like epithelium; often bilateral
Answer: Serous
Flashcard 47: _____ cells are seen in clear cell tumor of the ovary
Answer: Hobnail
Flashcard 48: Tuberculosis affects the _____ first, which can later spread to the testis (testis/epididymis)
Answer: epididymis
Flashcard 49: Testicular tumors may arise from either _____ or sex-cord stroma
Answer: germ cells
Flashcard 50: Syphilis affects the _____ first, which can later spread to the epididymis (testis/epididymis)
Answer: testis
Flashcard 51: _____ cell nests are seen in Brenner tumor of the ovary
Answer: Walthard
Flashcard 52: Histologically, _____ cell tumors are characterized by Call-Exner bodies, which are granulosa cells arranged in follicle / rosette-like collections around eosinophilic fluid, resembling primordial follicles
Answer: granulosa
Flashcard 53: A _____ is an ovarian germ cell tumor composed of large primitive "oocyte-like" cells with clear cytoplasm and central nuclei; described as "fried egg" cells
Answer: dysgerminoma
Flashcard 54: Periductal mastitis occurs due to a relative vitamin _____ deficiency, which results in squamous metaplasia of lactiferous ducts
Answer: A
Flashcard 55: Endometrial carcinoma arises via two distinct pathways: _____ and sporadic
Answer: hyperplasia
Flashcard 56: Ovarian mucinous carcinoma is CK 7 _____ and CK 20 positive
Answer: positive
Flashcard 57: Mammary duct _____ is inflammation with dilation of the subareolar duct
Answer: ectasia
Flashcard 58: Ovarian tumors may arise from three different cell types: 1. _____ 2. germ cells (e.g. oocyte) 3. sex cord stromal tissue (e.g. granulosa & theca cells)
Answer: surface epithelium
Flashcard 59: _____, also known as sarcoma botryoides, presents with bleeding and a grape-like mass protruding from the vagina or penis of a child
Answer: Embryonal rhabdomyosarcoma
Flashcard 60: Is LSIL a premalignant lesion?_____
Answer: No
Flashcard 61: In the vicinity of the discus proligerus (cumulus oophorus), are small spherical globules around which the granulosa cells arrange radially, forming _____ bodies in granulosa cell tumors
Answer: Call-Exner
Flashcard 62: Is HSIL a premalignant lesion?_____
Answer: Yes
Flashcard 63: According to the modified Gleason score, cribriform/glomeruloid/poorly formed glands in prostate carcinoma belongs to pattern _____
Answer: 4
Flashcard 64: Majority of potentially treatable Prostatic cancers detected on needle biopsy have Gleason scores of _____
Answer: 6-7
Flashcard 65: The most common paratesticular mesenchymal tumour is _____
Answer: lipoma
Flashcard 66: Myoepithelial cell markers like p63, basal cytokeratin (CK 5/6), calponin will be _____ in DCIS
Answer: positive
Flashcard 67: _____ criteria (histological) is used in the diagnosis of cervical pregnancy
Answer: Rubin's
Flashcard 68: _____ Change of fibroid are seen commonly in post-menopausal women, who present with a tumor which grows suddenly, causing pain and postmenopausal bleeding.
Answer: Sarcomatous
Flashcard 69: The vast majority of _____ tumors of the ovary are benign or borderline tumors
Answer: mucinous (serous/mucinous)
Flashcard 70: _____ is the most common stromal malignancy in the breast.
Answer: Angiosarcoma
Flashcard 71: The H&E stained specimen shows endometrial glands and surrounding stroma in myometrium, suggestive of _____
Answer: Adenomyosis
Flashcard 72: According to the modified Gleason score, comedo necrosis/solid cell nests in prostate carcinoma belongs to pattern _____
Answer: 5
Flashcard 73: What is the fixative used for testicular biopsy?_____
Answer: Bouin's fluid
Flashcard 74: Most testicular germ-cell tumors originate from a precursor lesion called _____
Answer: germ-cell neoplasia in situ (GCNIS)
Flashcard 75: _____ is a condition in which epithelium-lined diverticula extend into a hypertrophied muscularis layer of the fallopian tube.
Answer: Salpingitis isthmica nodosa
Flashcard 76: In the _____pubertal male, all teratomas are regarded as malignant, regardless of the presence of immature elements
Answer: post
Flashcard 77: What is the karyotype in people suffering from ovotesticular disorder?_____
Answer: 46, XX
Flashcard 78: Malignant mixed mllerian tumors (MMMTs) are _____ adenocarcinomas with malignant mesenchymal components
Answer: endometrial
Flashcard 79: _____ carcinoma is the most common type of breast carcinoma to present as an occult primary carcinoma
Answer: Lobular
Flashcard 80: Spermatocytic tumor is _____ in intracytoplasmic glycogen
Answer: poor
Flashcard 81: Microscopically, gynecomastia will show epithelial hyperplasia of the duct lining with characteristic tapering _____
Answer: micro-papillae
Flashcard 82: Grade _____ endometrial CA: glands are solid with cellular proliferation, architecture is lost and endometrium is packed with glands and little stroma
Answer: 3
Flashcard 83: Which ovarian tumor expresses OCT3/4 and NANOG?_____
Answer: Dysgerminoma
Flashcard 84: Zuska disease is another name for _____ or squamous metaplasia of lactiferous ducts
Answer: periductal mastitis
Flashcard 85: The most common benign paratesticular tumor is _____
Answer: adenomatoid tumor
Flashcard 86: Spermatocytic tumor is _____ for PLAP reactivity
Answer: negative
Flashcard 87: The most common malignant paratesticular tumor in adults is _____
Answer: liposarcoma
Flashcard 88: Gain in chromosome _____is the most frequent clonal acquired chromosomal changes seen in Phyllodes tumor
Answer: 1q
Flashcard 89: Can seminoma have an extratesticular origin site?_____
Answer: Yes
Flashcard 90: _____ tumors do not arise from Germ cell Neoplasia in situ
Answer: Spermatocytic
Flashcard 91: Stage _____ of endometrial carcinoma is the involvement of endocervical lining
Answer: II
Flashcard 92: Is lobule formation seen with gynecomastia?_____
Answer: No
Flashcard 93: Grade _____ endometrial CA: The glandular pattern is maintained, but cells show atypia
Answer: 1
Flashcard 94: Majority of advanced Prostatic cancers detected on needle biopsy have Gleason scores of _____
Answer: 8-10
Flashcard 95: p57KIP2 immunostaining is _____ in a partial mole.
Answer: positive
Flashcard 96: The most common cancer in patients who had cryptorchidism in childhood is _____.
Answer: seminoma
Flashcard 97: Powder burn spots over the peritoneum are seen in _____.
Answer: endometriosis
Flashcard 98: Endometrium in _____ shows a Swiss cheese pattern on HPE
Answer: Metropathia hemorrhagica
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