Endometrial Pathology — Flashcards

Flashcard 1: Endometrial carcinoma from the _____ pathway has a serous, papillary histology

Answer: sporadic

Flashcard 2: The H&E stained specimen shows endometrial glands and surrounding stroma in myometrium, suggestive of _____

Answer: Adenomyosis

Flashcard 3: Endometrial carcinoma from the _____ pathway has an endometrioid histology

Answer: hyperplasia

Flashcard 4: HER2-_____ cancers are most common subtype of breast cancer in patients with germline mutations in TP53 (Li Fraumeni syndrome)

Answer: positive

Flashcard 5: Chronic endometritis is characterized by _____ and plasma cells in the endometrium

Answer: lymphocytes

Flashcard 6: Grade _____ endometrial carcinoma: characterized by predominantly solid growth (> 50%) and loss of glandular architecture.

Answer: 3

Extra: FIGO Grading for Endometrioid Adenocarcinoma: - Grade 1: ≤ 5% solid growth (well-differentiated) - Grade 2: 6–50% solid growth (moderately differentiated) - Grade 3: > 50% solid growth (poorly differentiated) Note: Solid growth is defined as non-squamous and non-morular growth. "Back-to-back" glands with minimal stroma is a feature of Grade 1/well-differentiated carcinoma, whereas Grade 3 is defined by the loss of glandular architecture and presence of solid sheets.

Flashcard 7: The following image represents the _____ carcinoma subtype of invasive ductal carcinoma:

Answer: tubular

Flashcard 8: The H&E stained specimen shows endometrial glands and surrounding stroma in myometrium, suggestive of _____

Answer: Adenomyosis

Flashcard 9: In regards to cervical epithelium, if the tissue sample on the left is normal, is the tissue sample on the right: mildly dysplastic, moderately dysplastic, or severely dysplastic / carcinoma in situ? _____ VS

Answer: Severely Dysplastic / Carcinoma in Situ

Flashcard 10: A dysgerminoma is an ovarian germ cell tumor composed of large primitive "oocyte-like" cells with clear cytoplasm and central nuclei; described as "_____" cells

Answer: fried egg