Neuropathology — Flashcards

Flashcard 131: The most common variant of Charcot-Marie-Tooth disease is CMT1A is caused by a duplication of a region on chromosome _____

Answer: 17

Flashcard 132: Triton tumor is a malignant peripheral nerve sheath tumor with _____ differentiation, seen commmonly in neurofibromatosis type 1

Answer: rhabdomyoblastic

Flashcard 133: _____ classification is used for classifying neuroblastoma.

Answer: Shimada

Flashcard 134: In meningiomas without NF2 mutations, the most common mutations occur in _____

Answer: TNF receptor-associated factor 7 (TRAF7)

Flashcard 135: Is acoustic neuroma benign or malignant?_____

Answer: Benign

Flashcard 136: Transcriptional repressor Capicua (CIC) mutations are found exclusively in which brain tumor?_____

Answer: Oligodendroglioma

Flashcard 137: _____ is characterized by the thickening and fibrosis of the arachnoid membrane

Answer: Arachnoiditis

Flashcard 138: Which gene mutations are seen in oligodendroglioma?_____

Answer: IDH1/IDH2 mutations and 1p/19q co-deletion

Flashcard 139: Medulloblastoma and malignant pinealoblastoma are WHO grade _____ tumors

Answer: IV

Extra: Both are highly malignant embryonal tumors (WHO Grade IV). Note: They are NOT astrocytomas.

Flashcard 140: Stage 4S is associated with a _____ prognosis in neuroblastoma

Answer: good