Inflammation and Repair — Flashcards

Rheumatoid arthritis is associated with _____, which are areas of fibrinoid necrosis with palisading histiocytes in the skin and visceral organs (e.g. lung)

Swelling in inflammation is mediated by endothelial cell disruption (due to tissue damage) and endothelial cell contraction (caused by _____, histamine, and serotonin)

Necroptosis involves 2 unique kinases called _____ and RIPK3.

In the setting of chronic inflammation, macrophages can be activated to M2 macrophages by stimulation from _____ cells, resulting in a antiinflammatory phenotype

Berylliosis is characterized by a _____ histology and therefore is occasionally responsive to treatment with steroids

Granulomas due to sarcoidosis often have characteristic _____-shaped inclusions ('asteroid bodies') within giant cells

Integrin expression is upregulated on leukocytes by _____ and LTB4

The pathogenesis of Gout/Pseudogout involves Pattern Recognition Receptors detecting _____ in joints, which in response leads to an inflammatory cascade mediated by IL-1, causing the joint to be invaded by neutrophils

The key mediators of redness and warmth in inflammation are _____, prostaglandins, and bradykinin

_____ and serotonin are among the first mediators to be released during inflammation