Immunopathology — Flashcards

Superantigens result in a large release of cytokines, leading to massive _____ and shock

Definite diagnosis of IgG4-RD may be made by demonstrating IgG4 level exceeding _____ mg/dL, or >10 IgG4+ plasma cells per high-power field and an IgG4+:IgG+ plasma cell ratio of at least 40% on histologic tissue section

_____ is due to a defect in NADPH oxidase

Individuals with autoimmune polyendocrine syndrome 1 develop autoantibodies against IL-_____ and IL-22

Vogt Koyanagi Harada syndrome is an autoimmune disease  associated with HLA-_____ and HLA-DR4

Activated regulatory T cells produce _____, IL-35, and TGF-β (anti-inflammatory cytokines).

_____ is due to a defect in LFA-1 integrin (CD18) protein on phagocytes

Hint: specific type

Endotoxin/Lipopolysaccharide binding to CD14 and TLR4 of Macrophages releases _____, IL-6, TNF-a, and NO (proinflammatory cytokines)

Patients with _____ deficiency (complement) are unable to form the MAC (membrane attack complex) leading to increased Neisseria infections

IgA antibodies of _____ are highly sensitive for nasopharyngeal cancer