Hypersensitivity Reactions — Flashcards

Major clinical manifestations of GVHD result from the involvement of the immune system and epithelia of the skin, _____, and intestine

Paracortical hyperplasia is caused by stimuli that trigger _____-cell mediated immune responses (eg. viral infections)

Acute hemolytic transfusion reaction (AHTR) is Ig_____ mediated and caused by ABO incompatibility

_____ is a IHC marker seen with Breast carcinoma, urothelial carcinoma, salivary duct carcinoma and choriocarcinoma

The most common antibodies associated with TRALI are those that bind particularly _____ antigens

Toluidine blue is the special stain for _____ cells.

LE cell is a phagocytic _____ or _____ that has engulfed the denatured nucleus of an injured cell

--- Do with heme ---\nType II Hypersensitivity Disorders - Cytotoxic:\nTransfusion Reaction\n- Antibody against _____\n- IgM isohemagglutinins formed naturally in response to bacterial flora cause opsonization and complement activation\n- Leads to hemolysis\n**Hemolytic Disease of the Newborn (Erythroblastosis fetalis)\nAntibody = _____\n- Formed in _____ mother carrying _____ child\n- First pregnancy _____ (doesn't have to be viable pregnancy)\n- Antibody crosses placenta and injures subsequent fetuses\n- Prevent with _____ (anti-Rh, binds fetal red cells and prevents mothers immune system from reacting)\nABO blood typing and screening for other preformed Abs; always done in case of transplants.\nUniversal donor: type _____\nUniversal recipient: type _____\n(Ex) Type A can donate to _____ and _____. Type A can receive donations from _____ and _____.\n- Anti-B antibodies prevent donation from type B and type AB.\nHLA Typing - Microcytotoxicity test\nTests for MHC _____\nTest hundreds of different haplotypes to find a potential match.\nCells recognized by antibody will be attacked by complement and thus become leaky and take up dye.\nHLA Typing - Mixed lymphocyte reaction\nTests for MHC class _____\nTake donor cells and irradiate them (prevent proliferation). Irradiated donor cells are mixed with recipient cells to see if proliferation occurs.\nHigher radioactivity (thymidine) signifies _____ compatibility.

_____ cells are plasma cells characterized by the accumulation of multiple Russell bodies

_____ is caused by a defect in the BTK gene