Hematology — Flashcards

Flashcard 51: Non-hereditary causes of non-megaloblastic macrocytic anemia include _____ and alcoholism.

Answer: liver disease

Extra: **Mechanism of non-megaloblastic macrocytosis:** - **Liver disease**: Increased cholesterol and phospholipid deposition on the erythrocyte membrane leads to increased surface area (often forming target cells). - **Alcoholism**: Direct toxic effect on bone marrow erythropoiesis (independent of folate deficiency).

Flashcard 52: The pentad of classical symptoms seen in _____ may be remembered using the mnemonic FAT RN: F: Fever (1/5 patients)A*: Anemia (Microangiopathic Hemolytic Anemia)T*: ThrombocytopeniaR: Renal symptoms (1/2 of patients)-More common in HUSN: Neurologic symptoms (2/3 of patients)-More common in TTP

Answer: thrombotic thrombocytopenic purpura (TTP)

Flashcard 53: Localized T-cell lymphoma is treated by _____ while a disseminated disease requires chemotherapy.

Answer: radiation

Flashcard 54: TTP and HUS typically present with _____ PT and normal PTT

Answer: normal

Flashcard 55: What is the cause of hypercoagulable state in Cushing's syndrome?Increased _____ and decreased fibrinolysis

Answer: factor VIII, vWF

Flashcard 56: Factor XIII deficiency presents with _____ bleeding time (BT) and clotting time (CT) and a normal platelet count

Answer: normal

Flashcard 57: Patients with hereditary spherocytosis are at risk of _____ with parvovirus B19 infection of erythroid precursors

Answer: aplastic crisis

Flashcard 58: IgM-mediated hemolytic anemia is commonly associated with _____ infection and infectious mononucleosis

Answer: Mycoplasma pneumoniae

Flashcard 59: Tumor lysis syndrome is most common with treatment of _____ and acute lymphoblastic leukemia

Answer: lymphoma

Flashcard 60: Major clinical manifestations of GVHD result from the involvement of the immune system and epithelia of the skin, _____, and intestine

Answer: liver