Skin Tumors — Flashcards

Flashcard 51: What subtype of nevus has coalescent intraepidermal cell nests?_____

Answer: Dysplastic/Clark nevus

Flashcard 52: What are the four clinical variants of Kaposi sarcoma?

Answer: 1. Classic (European) 2. Endemic (African) 3. Iatrogenic (Transplant-related) 4. Epidemic (AIDS-associated)

Extra: All four variants typically present with cutaneous lesions (violaceous macules, plaques, or nodules). • **Classic**: Elderly Mediterranean/Eastern European men; indolent; lower limbs. • **Endemic**: Sub-Saharan Africa; includes an indolent cutaneous form and an aggressive lymphadenopathic form (especially in children). • **Iatrogenic**: Transplant recipients; management involves adjusting immunosuppression. • **Epidemic**: AIDS-defining illness; HHV-8 associated; aggressive with cutaneous, mucosal, and visceral involvement.

Flashcard 53: What type of nevus shows fascicular growth of spindle cells and elongated rete ridges?

Answer: Spitz nevus

Flashcard 54: Seborrheic keratosis and Acanthosis nigricans are associated with _____ gene mutations

Answer: FGFR3

Flashcard 55: Bowen's disease has a _____ potential for invasive malignancy

Answer: low

Flashcard 56: _____ is also known as turban tumor, due to hatlike growth

Answer: Cylindroma

Flashcard 57: A _____ nevus is a hyperpigmented (uniformly pigmented) macule

Answer: junctional

Flashcard 58: Dermatitis herpetiformis is associated with an increased risk of which malignancy?

Answer: Lymphoma (specifically Enteropathy-associated T-cell lymphoma)

Extra: Dermatitis herpetiformis is the cutaneous manifestation of celiac disease (gluten-sensitive enteropathy). Chronic inflammation in celiac disease predisposes to Enteropathy-associated T-cell lymphoma (EATL). While associated with malignancy, it is technically an autoimmune disease rather than a primary paraneoplastic syndrome.

Flashcard 59: Giant congenital melanocytic naevus or bathing trunk naevus is more than _____cm in size and HAS an increased malignant potential.

Answer: 20

Flashcard 60: _____ type is the commonest type of basal cell carcinoma

Answer: Nodular