Energy Production and Metabolism — Flashcards

Flashcard 41: The net ATP yield in the oxidation of palmitic acid is _____.

Answer: 106

Flashcard 42: Leber hereditary optic neuropathy (LHON) is primarily caused by a defect in which complex of the electron transport chain?

Answer: Complex I (NADH dehydrogenase)

Extra: LHON is a mitochondrial genetic disorder (maternal inheritance) caused by mutations in mitochondrial DNA (mtDNA) affecting Complex I of the electron transport chain. Note: Some older texts mention a classical association with defective cyanide metabolism/detoxification (rhodanese enzyme).

Flashcard 43: Lactic acidosis type _____ is due to anaerobic metabolism secondary to poor tissue perfusion.

Answer: A

Flashcard 44: In TCA cycle, both oxidative and synthetic reactions take place, hence it is also called an _____ pathway

Answer: amphibolic

Flashcard 45: Isocitrate dehydrogenase catalyzes the decarboxylation of isocitrate to form alpha-ketoglutarate. Which 2 ions are required?

Answer: Mg2+ or Mn2+

Flashcard 46: Propofol infusion syndrome is due to defect in _____ metabolism and electron transport chain function

Answer: mitochondrial

Flashcard 47: _____ competes with phosphate in glycolysis whereas _____ inhibits alpha-ketoglutarate dehydrogenase

Answer: Arsenate; Arsenite

Flashcard 48: An _____ bond is present between two phosphate groups.

Answer: acid anhydride

Flashcard 49: Depletion of _____ is a major cause of inhibited gluconeogenesis and hypoglycemia in ethanol intoxication.

Answer: Oxaloacetate (OAA)