Mitochondrial Diseases — Flashcards

NADH electrons from glycolysis enter the mitochondria via the _____ or glycerol-3-phosphate shuttle

Increased NADH/NAD+ (e.g. due to ethanol) causes increased conversion of _____ -> lactate, thus increasing risk for lactic acidosis

Neuropathy Ataxia Retinitis Pigmentosa syndrome is described as a _____ function disorder.

Isocitrate is converted to _____ via the enzyme isocitrate dehydrogenase

Creatine phosphate occurs in vertebrate skeletal muscle, _____, spermatozoa, and brain.

Propionyl-CoA is converted to _____ via the enzyme propionyl-CoA carboxylase

_____ is an inhibitor of complex III of the ETC

_____ is combined with oxaloacetate via the enzyme citrate synthase, forming citrate

_____ is an inhibitor of ATP synthase of the ETC

One function of the _____ shunt is to provide a source of NADPH, which is required for reductive reactions