Mitochondrial Diseases — Flashcards

Propofol infusion syndrome is due to defect in _____ metabolism and electron transport chain function

NADH electrons from glycolysis enter the mitochondria via the _____ or glycerol-3-phosphate shuttle

Increased NADH/NAD+ (e.g. due to ethanol) causes increased conversion of _____ -> lactate, thus increasing risk for lactic acidosis

Neuropathy Ataxia Retinitis Pigmentosa syndrome is described as a _____ function disorder.

Creatine phosphate occurs in vertebrate skeletal muscle, _____, spermatozoa, and brain.

Isocitrate is converted to _____ via the enzyme isocitrate dehydrogenase

_____ is combined with oxaloacetate via the enzyme citrate synthase, forming citrate

Propionyl-CoA is converted to _____ via the enzyme propionyl-CoA carboxylase

_____ is an inhibitor of complex III of the ETC

O2 is converted to _____ by the enzyme NADPH oxidase (oxidative burst)