Screening guidelines Practice Questions

Question 1

A scientist in Chicago is studying a new blood test to detect Ab to EBV with increased sensitivity and specificity. So far, her best attempt at creating such an exam reached 82% sensitivity and 88% specificity. She is hoping to increase these numbers by at least 2 percent for each value. After several years of work, she believes that she has actually managed to reach a sensitivity and specificity much greater than what she had originally hoped for. She travels to China to begin testing her newest blood test. She finds 2,000 patients who are willing to participate in her study. Of the 2,000 patients, 1,200 of them are known to be infected with EBV. The scientist tests these 1,200 patients' blood and finds that only 120 of them tested negative with her new exam. Of the patients who are known to be EBV-free, only 20 of them tested positive. Given these results, which of the following correlates with the exam's specificity?

Accepted Answer

98%

Answer

82%

Answer

90%

Answer

84%

Answer

86%

Question 2

A 68-year-old female presents to your office for her annual check-up. Her vitals are HR 85, T 98.8 F, RR 16, BP 125/70. She has a history of smoking 1 pack a day for 35 years, but states she quit five years ago. She had her last pap smear at age 64 and states all of her pap smears have been normal. She had her last colonoscopy at age 62, which was also normal. Which of the following is the next best test for this patient?

Accepted Answer

Chest CT scan

Answer

Pap smear

Answer

Chest radiograph

Answer

Abdominal ultrasound

Answer

Colonoscopy

Question 3

A genetic population study is being conducted to find the penetrance of a certain disease. This disease is associated with impaired iron metabolism and primarily affects the liver. Patients often present with diabetes and bronze skin pigmentation. After a genetic screening of 120 inhabitants with a family history of this disease, 40 were found to have the disease-producing genotype, but only 10 presented with symptoms. What are the chances of the screened patients with said genotype developing the disease phenotype?

Accepted Answer

25%

Answer

0.4%

Answer

40%

Answer

3%

Answer

4%

Question 4

You conduct a medical research study to determine the screening efficacy of a novel serum marker for colon cancer. The study is divided into 2 subsets. In the first, there are 500 patients with colon cancer, of which 450 are found positive for the novel serum marker. In the second arm, there are 500 patients who do not have colon cancer, and only 10 are found positive for the novel serum marker. What is the overall sensitivity of this novel test?

Accepted Answer

450 / (450 + 50)

Answer

450 / (450 + 10)

Answer

490 / (10 + 490)

Answer

490 / (50 + 490)

Answer

490 / (450 + 490)

Question 5

A 46-year-old woman presents to her primary care physician for her annual examination. At her prior exam one year earlier, she had a Pap smear which was within normal limits. Which of the following health screenings is recommended for this patient?

Accepted Answer

Colorectal screening

Answer

Blood glucose and/or HbA1c screening

Answer

Blood pressure at least once every 3 years

Answer

Yearly Pap smear

Answer

Bone mineral density screening

Question 6

A 28-year-old male presents to his primary care physician with complaints of intermittent abdominal pain and alternating bouts of constipation and diarrhea. His medical chart is not significant for any past medical problems or prior surgeries. He is not prescribed any current medications. Which of the following questions would be the most useful next question in eliciting further history from this patient?

Accepted Answer

"Can you tell me more about the symptoms you have been experiencing?"

Answer

"Does the diarrhea typically precede the constipation, or vice-versa?"

Answer

"Is the diarrhea foul-smelling?"

Answer

"Please rate your abdominal pain on a scale of 1-10, with 10 being the worst pain of your life"

Answer

"Are the symptoms worse in the morning or at night?"

Question 7

A 72-year-old man is brought to the physician by his wife for memory issues over the last 7 months. The patient's wife feels that he has gradually become more forgetful. He commonly misplaces his car keys and forgets his children's names. He seems to have forgotten how to make dinner and sometimes serves uncooked noodles or raw meat. One night he parked his car in a neighbor's bushes and was found wandering the street. He has a history of hypertension, hyperlipidemia, and COPD. Current medications include atorvastatin, metoprolol, ipratropium, and fluticasone. Vital signs are within normal limits. He is alert and oriented to person and place only. Neurologic examination shows no focal findings. His Mini-Mental State Examination score is 19/30. A complete blood count and serum concentrations of electrolytes, urea nitrogen, creatinine, thyroid-stimulating hormone, liver function tests, vitamin B12 (cobalamin), and folate are within the reference range. Which of the following is the most appropriate next step in diagnosis?

Accepted Answer

MRI of the brain

Answer

Electroencephalography

Answer

PET scan

Answer

Lumbar puncture

Answer

Neuropsychologic testing

Question 8

A 48-year-old man with a history of nephrolithiasis presents with acute-onset left flank pain. He says that the pain started suddenly 4 hours ago and has progressively worsened. He describes the pain as severe, sharp, and localized to the left flank. The patient denies any fever, chills, nausea, vomiting, or dysuria. His past medical history is significant for nephrolithiasis diagnosed 4 years ago status post shockwave lithotripsy. The patient says, "I’m allergic to many pain medications, but there is one that I get all the time when I have this pain. I think it starts with D". He is afebrile and his vital signs are stable. On physical examination, he is writhing in pain and moaning. Exquisite left costovertebral angle tenderness is noted. Laboratory findings, including a urinalysis, are unremarkable. IV fluid resuscitation is administered.
Which of the following is the best next step in the management of this patient?

Accepted Answer

Administer ibuprofen and acetaminophen for pain control

Answer

Non-contrast CT of the abdomen and pelvis

Answer

Administer dilaudid (hydromorphone) for pain control

Answer

Discharge patient with prescription of dilaudid with follow-up in 3 months

Answer

Admit to hospital floor for IV dilaudid patient-controlled analgesia

Question 9

A 15-year-old Caucasian female presents with Parkinson-like symptoms. Serum analysis shows increased levels of free copper and elevated liver enzymes. What test would prove most helpful in diagnosing the patient's underlying disease?

Accepted Answer

Slit lamp examination

Answer

Reflex test

Answer

Serum detection of anti-myelin antibodies

Answer

Vitamin B12 test

Answer

CT scan

Question 10

A 28-year-old asymptomatic pregnant woman at 12 weeks gestation presents for prenatal care. She has no personal or family history of diabetes. Her BMI is 32 kg/m². She had a random glucose of 118 mg/dL at her first visit. She asks about gestational diabetes screening. Considering her risk factors and current pregnancy, what is the most appropriate screening approach?

Accepted Answer

Perform fasting glucose and hemoglobin A1c now to assess for preexisting diabetes

Answer

Perform 3-hour oral glucose tolerance test at 16 weeks

Answer

Diagnose gestational diabetes based on random glucose and begin treatment

Answer

Perform 1-hour glucose challenge test now

Answer

Defer screening until 24-28 weeks gestation per routine protocol

Screening guidelines

Study Resources

Lessons

Questions

Flashcards

Lessons

Principles of screening

Cancer screening recommendations (by cancer type)

Cardiovascular disease screening

Infectious disease screening

Mental health screening

Developmental screening in pediatrics

Geriatric screening protocols

Prenatal screening

Evidence basis for screening recommendations

Risk-stratified screening approaches

Special population screening considerations

Screening interval determination

Limitations and controversies in screening

Practice Questions

Flashcards

About Screening guidelines for USMLE

Lessons in Screening guidelines

Master Screening guidelines