Neurology Practice Questions

Question 1

A 42-year-old woman presents with fatigue, muscle aches, and widespread pain. She has multiple tender points but normal inflammatory markers. Sleep is poor. What is the most appropriate initial treatment?

Accepted Answer

Pregabalin

Answer

NSAIDs

Answer

Prednisolone

Answer

Methotrexate

Answer

Physiotherapy alone

Question 2

A 49-year-old man presents with progressive weakness in his arms and legs over 24 months. He has bulbar symptoms including dysphagia and dysarthria. EMG shows widespread denervation. What is the most important prognostic factor?

Accepted Answer

Bulbar involvement

Answer

Age at onset

Answer

Rate of progression

Answer

Site of onset

Answer

Family history

Question 3

A 38-year-old woman presents with recurrent episodes of severe abdominal pain and psychiatric symptoms. Her urine turns dark during attacks. Family history reveals similar episodes. What is the inheritance pattern?

Accepted Answer

Autosomal dominant

Answer

Autosomal recessive

Answer

X-linked recessive

Answer

X-linked dominant

Answer

Mitochondrial

Question 4

A 55-year-old woman presents with progressive dyspnea and fatigue. Echocardiogram shows severe aortic regurgitation with LV end-systolic dimension 58mm and EF 48%. She is asymptomatic at rest. What is the most appropriate management?

Accepted Answer

Aortic valve replacement

Answer

Medical management

Answer

ACE inhibitors and monitoring

Answer

Exercise stress testing

Answer

Cardiac catheterization

Question 5

A 28-year-old woman presents with sudden onset severe headache during exercise. She vomits and has neck stiffness. CT head shows subarachnoid hemorrhage. What is the most likely cause?

Accepted Answer

Berry aneurysm

Answer

Arteriovenous malformation

Answer

Carotid dissection

Answer

Hypertensive hemorrhage

Answer

Trauma

Question 6

A 41-year-old man presents with progressive weakness in his hands and arms over 12 months. He has muscle fasciculations and hyperreflexia. EMG shows both acute and chronic denervation changes. What is the prognosis?

Accepted Answer

Poor with 3-5 year survival

Answer

Excellent with treatment

Answer

Good with supportive care

Answer

Variable depending on subtype

Answer

Stable with medication

Question 7

A 62-year-old man presents with progressive weakness in his arms and legs over 18 months. He has difficulty speaking and swallowing. EMG shows widespread denervation. What is the most important prognostic factor?

Accepted Answer

Bulbar involvement

Answer

Age at onset

Answer

Site of onset

Answer

Rate of progression

Answer

Genetic factors

Question 8

A 57-year-old woman presents with progressive memory loss and behavioral changes. MRI shows frontotemporal atrophy. What is the most likely initial symptom domain affected?

Accepted Answer

Behavioral changes

Answer

Memory loss

Answer

Language difficulties

Answer

Motor symptoms

Answer

Visual problems

Question 9

A 67-year-old man presents with confusion, falls, and urinary incontinence over 4 months. MRI shows ventricular dilatation with periventricular changes. What is the most appropriate diagnostic test?

Accepted Answer

Large-volume lumbar puncture

Answer

Lumbar puncture with pressure measurement

Answer

CSF flow studies

Answer

Intracranial pressure monitoring

Answer

Cognitive testing

Neurology

Study Resources

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Dementia and delirium

Epilepsy and seizures

Headache and migraine

Stroke and TIA

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