A 42-year-old man comes to the physician for 1 month of worsening right knee pain. He has not had any trauma other than stubbing his toe 3 days ago at the garage where he works as a mechanic. Examination of the right knee shows swelling and erythema with fluctuance over the inferior patella. There is tenderness on palpation of the patella but no joint line tenderness or warmth. The range of flexion is limited because of the pain. Which of the following is the most likely underlying cause of this patient's symptoms?
Q1142
A 42-year-old woman presents to her primary care provider with vision loss. She reports that twice over the last 2 weeks she has had sudden “black out” of the vision in her right eye. She notes that both episodes were painless and self-resolved over approximately a minute. The patient’s past medical history is significant for hypertension, diet-controlled diabetes mellitus, and hypothyroidism. Her family history is notable for coronary artery disease in the patient’s father and multiple sclerosis in her mother. Ophthalmologic and neurologic exam is unremarkable. Which of the following is the best next step in management?
Q1143
A 47-year-old man presents to the emergency department due to a rash. He states the rash started last night and is very concerning to him. The patient cannot remember being exposed to any environmental stimuli such as new detergents or poison ivy. The patient recently started following with a primary care provider who is helping him manage his arthritis and a new onset cough. His temperature is 99.5°F (37.5°C), blood pressure is 127/68 mmHg, pulse is 125/min, respirations are 18/min, and oxygen saturation is 98% on room air. Physical exam is notable for the findings of coalescing erythematous macules, bullae, desquamation, and mucositis only on the upper half of his back. Cardiopulmonary exam and abdominal exam are within normal limits. Inspection of the patient’s oropharynx reveals ulcers and erythema. Which of the following is the most likely diagnosis?
Q1144
A 42-year-old woman presents to her family physician with a headache. The patient reports that the symptoms started about 2 hours ago when she woke up and have not improved. She states the pain is moderate, throbbing, tight in character, and is located in the occipital region bilaterally. The patient denies any visual and audio disturbances, nausea, and vomiting. She recalls 2 similar headaches in the past month. She has no other relevant medical history. Current medications are alendronate and a daily multivitamin. The patient works long hours as a corporate attorney. A review of systems is significant for mild photophobia. Her temperature is 37.0°C (98.6°F), the blood pressure is 110/70 mm Hg, the pulse is 70/min, the respiratory rate is 18/min, and the oxygen saturation is 98% on room air. On physical exam, the patient is alert and oriented. There is moderate tenderness to palpation diffusely over the upper posterior cervical muscles and occipital region of the scalp. The remainder of the physical exam is normal. Laboratory tests are normal. Urine pregnancy test is negative. What is the next best step in management?
Q1145
A 38-year-old man comes to the physician because of a 1-month history of fever and a cough productive of a moderate amount of yellowish sputum. He has had a 6-kg (13-lb) weight loss during this period. He emigrated from the Middle East around 2 years ago. His father died of lung cancer at the age of 54 years. He has smoked one pack of cigarettes daily for 18 years. He appears malnourished. His temperature is 38.1°C (100.6°F), pulse is 101/min, and blood pressure is 118/72 mm Hg. Crackles are heard on auscultation of the chest. Cardiac examination shows no abnormalities. The abdomen is soft and nontender. Laboratory studies show:
Hemoglobin 12.3 g/dL
Leukocyte count 13,200/mm3
Platelet count 330,000/mm3
Erythrocyte sedimentation rate 66 mm/h
Serum
Urea nitrogen 16 mg/dL
Glucose 122 mg/dL
Creatinine 0.9 mg/dL
Urinalysis is within normal limits. An x-ray of the chest is shown. Which of the following is the most appropriate next step in management?
Q1146
A 32-year-old woman comes to the physician because of weight gain, generalized weakness, and irregular menstrual cycles for the past 16 months. She began having symptoms of insomnia and depression 10 months ago. More recently, she has been having difficulties rising from a chair. She has a 2-year history of hypertension. Current medications include citalopram and hydrochlorothiazide. She is 168 cm (5 ft 6 in) tall and weighs 100 kg (220 lb). BMI is 36 kg/m2. Her pulse is 92/min, respirations are 18/min, and blood pressure is 134/76 mm Hg. She appears tired and has a full, plethoric face and central obesity. Examination of the skin shows violaceous linear striations on her lower abdomen. Two midnight serum cortisol studies show measurements of 288 μg/L and 253 μg/L (N < 90); a 24-hour urinary cortisol measurement was 395 μg (N < 300). Upon follow-up laboratory examination, the patient's serum ACTH levels were also elevated at 136 pg/mL (N = 7–50). Which of the following is the most appropriate next step in evaluation?
Q1147
A 17-year-old male presents to your office complaining of polyuria, polydipsia, and unintentional weight loss of 12 pounds over the past 3 months. On physical examination, the patient is tachypneic with labored breathing. Which of the following electrolyte abnormalities would you most likely observe in this patient?
Q1148
A 53-year-old Asian woman comes to the physician because of a 2-month history of severe pain in her right leg while walking. She used to be able to walk a half-mile (800-m) to the grocery store but has been unable to walk 200 meters without stopping because of the pain over the past month. She can continue to walk after a break of around 5 minutes. She has hypertension, atrial fibrillation, and type 2 diabetes mellitus. She has smoked one pack of cigarettes daily for the past 32 years. Current medications include metformin, enalapril, aspirin, and warfarin. Vital signs are within normal limits. Examination shows an irregularly irregular pulse. The right lower extremity is cooler than the left lower extremity. The skin over the right leg appears shiny and dry. Femoral pulses are palpated bilaterally; pedal pulses are diminished on the right side. Which of the following is the most appropriate next step in management?
Q1149
A 68-year-old woman comes to the physician for a follow-up visit for elevated blood pressure. Two weeks ago, her blood pressure was 154/78 mm Hg at a routine visit. Subsequent home blood pressure measurements at days 5, 10, and 14 have been: 156/76 mm Hg, 158/80 mm Hg, and 160/80 mm Hg. She has trouble falling asleep but otherwise feels well. She had a cold that resolved with over-the-counter medication 2 weeks ago. She has a history of primary hypothyroidism and a cyst in the right kidney, which was found incidentally 20 years ago. She takes levothyroxine. She is 178 cm (5 ft 10 in) tall and weighs 67 kg (148 lb); BMI is 21.3 kg/m2. Her pulse is 82/min, and blood pressure is 162/79 mm Hg. Examination shows no abnormalities. Laboratory studies, including thyroid function studies, serum electrolytes, and serum creatinine, are within normal limits. Which of the following is the most likely underlying cause of this patient's blood pressure findings?
Q1150
A 58-year-old woman presents to the physician with a throbbing headache. She says she had it for the last year and it’s usually located in the right temporal area. There is localized tenderness over the scalp. During the last 2 weeks, she experienced 3 episodes of transient loss of vision on the right side, without ocular pain. On physical examination, her vital signs are normal. Palpation reveals that the pulsations of the superficial temporal artery on the right side are reduced in amplitude. Laboratory studies show:
Blood hemoglobin 10.7 g/dL (6.64 mmol/L)
Leukocyte count 8,000/mm3 (8.0 x 109/L)
Platelet count 470,000/mm3 (470 x 109/L)
Erythrocyte sedimentation rate 60 mm/h (60 mm/h)
Which of the following conditions is most likely to co-exist with the presenting complaint in this woman?
Cardiology US Medical PG Practice Questions and MCQs
Question 1141: A 42-year-old man comes to the physician for 1 month of worsening right knee pain. He has not had any trauma other than stubbing his toe 3 days ago at the garage where he works as a mechanic. Examination of the right knee shows swelling and erythema with fluctuance over the inferior patella. There is tenderness on palpation of the patella but no joint line tenderness or warmth. The range of flexion is limited because of the pain. Which of the following is the most likely underlying cause of this patient's symptoms?
A. Inflammation of the patellar tendon
B. Deposition of crystals in the joint
C. Noninflammatory degeneration of the joint
D. Inflammation of periarticular fluid-filled sac (Correct Answer)
E. Infection of the joint
Explanation: ***Inflammation of periarticular fluid-filled sac***
- The patient's symptoms (swelling, erythema, fluctuance over the inferior patella, tenderness on palpation of the patella, and limited flexion due to pain) are highly suggestive of **prepatellar bursitis**. The history of stubbing his toe and working as a mechanic (suggesting kneeling) further supports this.
- A periarticular fluid-filled sac (bursa) becomes inflamed, causing localized pain, swelling, and tenderness, specifically in the prepatellar region, without true intra-articular involvement.
*Inflammation of the patellar tendon*
- **Patellar tendinitis** (jumper's knee) typically presents with pain directly over the patellar tendon, usually exacerbated by activities involving jumping or forceful knee extension, not necessarily with fluctuant swelling over the patella itself.
- While there can be swelling, it's usually less diffuse and fluctuant compared to bursitis, and primarily involves the tendon structure rather than a fluid-filled sac.
*Deposition of crystals in the joint*
- Crystal arthropathies like **gout** or **pseudogout** typically cause sudden, severe monoarticular arthritis with exquisite pain, redness, and swelling, often affecting the great toe (gout) or knee with true intra-articular inflammation.
- While very possible given the stubbed toe, the description of **fluctuance over the inferior patella** and lack of joint line tenderness makes a bursitis more likely than an intra-articular crystal deposition. Analysis of synovial fluid would confirm.
*Noninflammatory degeneration of the joint*
- **Osteoarthritis** typically presents with gradual onset of pain, stiffness, and crepitus, often worse with activity and relieved by rest. It is characterized by **joint line tenderness**, osteophytes, and narrowing of the joint space.
- The acute onset of significant swelling, erythema, and fluctuance points away from noninflammatory degeneration as the primary cause.
*Infection of the joint*
- **Septic arthritis** would cause severe pain, swelling, erythema, and warmth of the entire joint, often with systemic symptoms like fever and chills, and marked limitation of both active and passive range of motion.
- While infection of a bursa (**septic bursitis**) is a possibility, the question asks for the most likely underlying cause given the overall presentation, and sterile inflammatory bursitis is often more common initially, especially with mechanical irritation like repetitive kneeling or minor trauma. The description of **no joint line tenderness or warmth** makes septic arthritis less likely.
Question 1142: A 42-year-old woman presents to her primary care provider with vision loss. She reports that twice over the last 2 weeks she has had sudden “black out” of the vision in her right eye. She notes that both episodes were painless and self-resolved over approximately a minute. The patient’s past medical history is significant for hypertension, diet-controlled diabetes mellitus, and hypothyroidism. Her family history is notable for coronary artery disease in the patient’s father and multiple sclerosis in her mother. Ophthalmologic and neurologic exam is unremarkable. Which of the following is the best next step in management?
A. Intravenous dexamethasone
B. Emergent referral to ophthalmology
C. Ultrasound of the carotid arteries (Correct Answer)
D. Check serum inflammatory markers
E. MRI of the brain
Explanation: **Ultrasound of the carotid arteries**
- The patient's symptoms of **transient monocular vision loss** ("black out" vision in one eye that self-resolved) are highly suggestive of **amaurosis fugax**.
- Amaurosis fugax is often caused by **atheroembolic disease** originating from the ipsilateral carotid artery, making carotid ultrasound the best next step to assess for **carotid stenosis**.
*Intravenous dexamethasone*
- This treatment is typically used for **acute inflammation** or **autoimmune conditions**, such as optic neuritis related to multiple sclerosis, which is less likely given the painless, transient, and self-resolving nature of the vision loss.
- While the mother has multiple sclerosis, the daughter's symptoms do not align with a typical demyelinating event, and the primary concern is underlying vascular pathology.
*Emergent referral to ophthalmology*
- While an ophthalmology consult may eventually be warranted, the immediate concern is to identify the **underlying systemic cause** of the **embolic event** to prevent future, more severe cerebrovascular events like a stroke.
- The vision loss in amaurosis fugax is usually a symptom of a more serious **systemic vascular problem** originating proximal to the eye.
*Check serum inflammatory markers*
- Inflammatory markers (e.g., ESR, CRP) would be elevated in conditions like **temporal arteritis**, but the patient's vision loss is painless and self-resolving, which is inconsistent with the typical presentation of temporal arteritis.
- Furthermore, temporal arteritis usually presents in older patients (>50 years old), and would cause more persistent vision loss, often accompanied by tenderness over the temporal artery and jaw claudication.
*MRI of the brain*
- An MRI of the brain would be appropriate if there were concerns for a **stroke** or **demyelinating disease** affecting the optic pathways or brain, but the transient monocular vision loss points to an issue with the retinal circulation, not necessarily the brain.
- While a stroke is a concern, the acute vision loss is more indicative of a **retinal event**, which originates from a more proximal arterial source.
Question 1143: A 47-year-old man presents to the emergency department due to a rash. He states the rash started last night and is very concerning to him. The patient cannot remember being exposed to any environmental stimuli such as new detergents or poison ivy. The patient recently started following with a primary care provider who is helping him manage his arthritis and a new onset cough. His temperature is 99.5°F (37.5°C), blood pressure is 127/68 mmHg, pulse is 125/min, respirations are 18/min, and oxygen saturation is 98% on room air. Physical exam is notable for the findings of coalescing erythematous macules, bullae, desquamation, and mucositis only on the upper half of his back. Cardiopulmonary exam and abdominal exam are within normal limits. Inspection of the patient’s oropharynx reveals ulcers and erythema. Which of the following is the most likely diagnosis?
A. Stevens-Johnson syndrome (Correct Answer)
B. Erythema multiforme
C. Herpes zoster
D. Herpes simplex virus
E. Toxic epidermal necrolysis
Explanation: ***Stevens-Johnson syndrome***
- This patient presents with a **rash of coalescing erythematous macules, bullae, desquamation, and mucositis in the oropharynx**, which are characteristic of SJS.
- The recent initiation of new medication for arthritis and a cough suggests a **drug-induced etiology**, a common trigger for SJS.
*Erythema multiforme*
- While erythema multiforme can present with a rash and some **mucosal involvement**, it typically manifests with **targetoid lesions** (target lesions with distinct rings), which are not described here.
- It is generally a less severe condition than SJS and typically involves less extensive skin detachment.
*Herpes zoster*
- Herpes zoster (shingles) presents as a **unilateral, dermatomal rash** of vesicles on an erythematous base, often accompanied by pain and itching.
- The described rash is **diffuse and coalescing**, not dermatomal, making herpes zoster unlikely.
*Herpes simplex virus*
- Herpes simplex virus (HSV) typically causes **localized clusters of vesicles** on an erythematous base, most commonly around the mouth (cold sores) or genitals.
- The extensive, diffuse rash with desquamation and bullae is inconsistent with typical HSV infection.
*Toxic epidermal necrolysis*
- **Toxic epidermal necrolysis (TEN)** is a more severe form of SJS, often considered a continuum of the same disease, but it involves **>30% body surface area** skin detachment.
- The patient's rash is noted "only on the upper half of his back," suggesting less extensive involvement than typically seen in TEN.
Question 1144: A 42-year-old woman presents to her family physician with a headache. The patient reports that the symptoms started about 2 hours ago when she woke up and have not improved. She states the pain is moderate, throbbing, tight in character, and is located in the occipital region bilaterally. The patient denies any visual and audio disturbances, nausea, and vomiting. She recalls 2 similar headaches in the past month. She has no other relevant medical history. Current medications are alendronate and a daily multivitamin. The patient works long hours as a corporate attorney. A review of systems is significant for mild photophobia. Her temperature is 37.0°C (98.6°F), the blood pressure is 110/70 mm Hg, the pulse is 70/min, the respiratory rate is 18/min, and the oxygen saturation is 98% on room air. On physical exam, the patient is alert and oriented. There is moderate tenderness to palpation diffusely over the upper posterior cervical muscles and occipital region of the scalp. The remainder of the physical exam is normal. Laboratory tests are normal. Urine pregnancy test is negative. What is the next best step in management?
A. Administer high-flow oxygen, ibuprofen 200 mg orally, and sumatriptan 6 mg subcutaneously
B. Non-contrast CT of the head and neck
C. Recommend lifestyle changes, relaxation techniques, and massage therapy (Correct Answer)
D. T1/T2 MRI of the head and neck
E. Temporal artery biopsy
Explanation: ***Recommend lifestyle changes, relaxation techniques, and massage therapy***
- The patient's presentation with a **moderate, throbbing, tight, bilateral occipital headache**, associated with stress from long work hours and **tenderness in the posterior cervical and occipital muscles**, is highly suggestive of a **tension-type headache**.
- Given the lack of red flag symptoms (e.g., focal neurological deficits, fever, severe sudden onset headache), and mild photophobia, **non-pharmacological approaches** (lifestyle changes, relaxation, massage) are the most appropriate first-line symptomatic and prophylactic management for frequent tension-type headaches.
*Administer high-flow oxygen, ibuprofen 200 mg orally, and sumatriptan 6 mg subcutaneously*
- This combination of treatments (high-flow oxygen, sumatriptan) is typically reserved for **cluster headaches** and **migraines**, not tension-type headaches.
- While ibuprofen can be used for tension headaches, the **sumatriptan and oxygen are not indicated** and could lead to unnecessary side effects.
*Non-contrast CT of the head and neck*
- **Neuroimaging (CT or MRI) is not indicated** for a recurrent headache with typical tension-type features and no red flag symptoms like sudden onset "thunderclap" headache, focal neurological deficits, papilledema, or new headache in an immunocompromised patient.
- Doing so would expose the patient to **unnecessary radiation** and cost.
*T1/T2 MRI of the head and neck*
- Similar to CT, **MRI is not indicated** at this stage for a headache that is consistent with a benign primary headache disorder.
- MRI is generally reserved for headache evaluation when there are concerns for **structural brain abnormalities** (e.g., tumors, vascular malformations) or neurological deficits.
*Temporal artery biopsy*
- **Temporal artery biopsy** is the gold standard for diagnosing **giant cell arteritis (GCA)**, a condition typically seen in patients over 50 years old with symptoms like new-onset headache, jaw claudication, visual disturbances, and elevated inflammatory markers (ESR, CRP).
- The patient's age (42), lack of systemic symptoms of GCA, and normal laboratory tests make this diagnosis **highly unlikely**.
Question 1145: A 38-year-old man comes to the physician because of a 1-month history of fever and a cough productive of a moderate amount of yellowish sputum. He has had a 6-kg (13-lb) weight loss during this period. He emigrated from the Middle East around 2 years ago. His father died of lung cancer at the age of 54 years. He has smoked one pack of cigarettes daily for 18 years. He appears malnourished. His temperature is 38.1°C (100.6°F), pulse is 101/min, and blood pressure is 118/72 mm Hg. Crackles are heard on auscultation of the chest. Cardiac examination shows no abnormalities. The abdomen is soft and nontender. Laboratory studies show:
Hemoglobin 12.3 g/dL
Leukocyte count 13,200/mm3
Platelet count 330,000/mm3
Erythrocyte sedimentation rate 66 mm/h
Serum
Urea nitrogen 16 mg/dL
Glucose 122 mg/dL
Creatinine 0.9 mg/dL
Urinalysis is within normal limits. An x-ray of the chest is shown. Which of the following is the most appropriate next step in management?
A. Perform an interferon-gamma release assay
B. Perform transbronchial lung biopsy of the suspected lesion
C. Collect sputum specimens for acid-fast bacilli smear microscopy, culture, and nucleic acid amplification (Correct Answer)
D. Perform a high-resolution CT scan of the chest
E. Start treatment with oral levofloxacin
Explanation: ***Collect sputum specimens for acid-fast bacilli smear microscopy, culture, and nucleic acid amplification***
- The patient presents with classic symptoms of **pulmonary tuberculosis (TB)**, including chronic cough with sputum, fever, weight loss, and crackles on chest auscultation. His history of emigrating from the Middle East (an endemic area for TB) increases suspicion.
- Initial diagnosis of active TB involves **sputum analysis** for acid-fast bacilli (AFB) smear, culture (gold standard), and nucleic acid amplification test (NAAT) for rapid detection and drug susceptibility.
*Perform an interferon-gamma release assay*
- An **interferon-gamma release assay (IGRA)** detects latent TB infection, not active disease.
- While useful for screening, it does not confirm active infection and would not be the most appropriate first diagnostic step given the strong clinical suspicion for active disease.
*Perform transbronchial lung biopsy of the suspected lesion*
- **Transbronchial lung biopsy** is an invasive procedure and is typically reserved for cases where sputum studies are nondiagnostic or when there's a need to differentiate TB from other conditions like malignancy, especially if the lesions are not easily accessible by sputum.
- It carries risks and is not the initial preferred method for suspected TB.
*Perform a high-resolution CT scan of the chest*
- A **high-resolution CT (HRCT) scan** provides more detailed imaging than a standard chest X-ray and can help characterize lung lesions, identify cavities, and assess the extent of disease.
- However, while it can support the diagnosis of TB, it is an imaging study and does not provide microbiological confirmation, which is essential for treatment.
*Start treatment with oral levofloxacin*
- **Levofloxacin** is an antibiotic that might be used in some cases of pneumonia, but it is not the standard first-line treatment for suspected tuberculosis.
- Empiric treatment with a single antibiotic like levofloxacin without microbiological confirmation can delay proper TB diagnosis and treatment, potentially leading to **drug resistance**.
Question 1146: A 32-year-old woman comes to the physician because of weight gain, generalized weakness, and irregular menstrual cycles for the past 16 months. She began having symptoms of insomnia and depression 10 months ago. More recently, she has been having difficulties rising from a chair. She has a 2-year history of hypertension. Current medications include citalopram and hydrochlorothiazide. She is 168 cm (5 ft 6 in) tall and weighs 100 kg (220 lb). BMI is 36 kg/m2. Her pulse is 92/min, respirations are 18/min, and blood pressure is 134/76 mm Hg. She appears tired and has a full, plethoric face and central obesity. Examination of the skin shows violaceous linear striations on her lower abdomen. Two midnight serum cortisol studies show measurements of 288 μg/L and 253 μg/L (N < 90); a 24-hour urinary cortisol measurement was 395 μg (N < 300). Upon follow-up laboratory examination, the patient's serum ACTH levels were also elevated at 136 pg/mL (N = 7–50). Which of the following is the most appropriate next step in evaluation?
A. MRI of the head with contrast
B. High-dose dexamethasone suppression test (Correct Answer)
C. Measure ACTH levels in inferior petrosal sinuses
D. Bilateral adrenalectomy
E. CT scan of the abdomen with contrast
Explanation: ***High-dose dexamethasone suppression test***
- Elevated **midnight serum cortisol** and **24-hour urinary cortisol**, combined with elevated **ACTH levels**, confirm **ACTH-dependent Cushing's syndrome**.
- A high-dose dexamethasone suppression test helps **differentiate** between a pituitary adenoma (Cushing's disease), which typically suppresses with high-dose dexamethasone, and ectopic ACTH production, which usually does not.
*MRI of the head with contrast*
- While an MRI of the head might eventually be performed to localize a pituitary adenoma, it is **not the immediate next step** after establishing ACTH dependency.
- The high-dose dexamethasone suppression test provides crucial **functional information** about the source of ACTH prior to imaging.
*Measure ACTH levels in inferior petrosal sinuses*
- **Inferior petrosal sinus sampling (IPSS)** is used to **confirm and lateralize** a pituitary source of ACTH when imaging studies are equivocal or negative.
- This is an **invasive procedure** typically reserved for after the high-dose dexamethasone suppression test has been performed and further distinction is needed.
*Bilateral adrenalectomy*
- **Bilateral adrenalectomy** is a treatment option for Cushing's syndrome, particularly for severe cases or when other treatments fail.
- It is an **irreversible surgical procedure** and would only be considered after a definitive diagnosis and localization of the source of excess cortisol.
*CT scan of the abdomen with contrast*
- A CT scan of the abdomen is primarily used to evaluate for **adrenal adenomas or carcinomas** in cases of **ACTH-independent Cushing's syndrome**.
- Given the **elevated ACTH levels**, an adrenal etiology is less likely, making this an inappropriate next step.
Question 1147: A 17-year-old male presents to your office complaining of polyuria, polydipsia, and unintentional weight loss of 12 pounds over the past 3 months. On physical examination, the patient is tachypneic with labored breathing. Which of the following electrolyte abnormalities would you most likely observe in this patient?
A. Hypophosphatemia
B. Hypermagnesemia
C. Hyperkalemia
D. Hyponatremia (Correct Answer)
E. Hyperphosphatemia
Explanation: ***Hyponatremia***
- This patient's symptoms of polyuria, polydipsia, and weight loss, along with **tachypnea and labored breathing**, are highly suggestive of **diabetic ketoacidosis (DKA)**.
- **Hyponatremia** is the **most consistently observed** electrolyte abnormality in DKA, present in nearly all cases at initial presentation.
- This is typically **pseudohyponatremia** caused by the osmotic effect of severe hyperglycemia—glucose pulls water into the extracellular space, diluting the measured sodium concentration.
- The **corrected sodium** can be calculated using: Corrected Na = Measured Na + 0.016 × (Glucose - 100), which typically reveals a more normal sodium level.
- True hyponatremia from sodium loss via **osmotic diuresis** can also occur but is usually masked by the dilutional effect.
*Hyperkalemia*
- While serum potassium may appear normal or even elevated initially due to **transcellular shifts** (acidosis causes potassium to move from intracellular to extracellular space in exchange for hydrogen ions), this is not the most consistently observed abnormality.
- **Total body potassium is always depleted** in DKA due to osmotic diuresis and vomiting.
- Many patients present with normal or even low potassium levels despite acidosis.
- Potassium levels require careful monitoring during treatment as insulin therapy drives potassium back into cells, potentially causing life-threatening hypokalemia.
*Hypophosphatemia*
- While **phosphate levels** can fluctuate in DKA due to osmotic diuresis, initial presentation often involves normal or even elevated phosphate levels due to cellular shifts.
- Significant **hypophosphatemia** is more typically observed during treatment as insulin drives phosphate back into the cells, similar to potassium.
*Hypermagnesemia*
- **Hypermagnesemia** is uncommon in DKA and is usually associated with impaired renal excretion or excessive magnesium intake.
- The symptoms described do not point towards magnesium imbalance.
*Hyperphosphatemia*
- Although cellular shifts can initially raise serum phosphate, sustained **hyperphosphatemia** is not a characteristic or common electrolyte abnormality seen in the acute presentation of DKA.
- More typically, total body phosphate is depleted due to **osmotic diuresis**.
Question 1148: A 53-year-old Asian woman comes to the physician because of a 2-month history of severe pain in her right leg while walking. She used to be able to walk a half-mile (800-m) to the grocery store but has been unable to walk 200 meters without stopping because of the pain over the past month. She can continue to walk after a break of around 5 minutes. She has hypertension, atrial fibrillation, and type 2 diabetes mellitus. She has smoked one pack of cigarettes daily for the past 32 years. Current medications include metformin, enalapril, aspirin, and warfarin. Vital signs are within normal limits. Examination shows an irregularly irregular pulse. The right lower extremity is cooler than the left lower extremity. The skin over the right leg appears shiny and dry. Femoral pulses are palpated bilaterally; pedal pulses are diminished on the right side. Which of the following is the most appropriate next step in management?
A. MRI spine screening
B. Duplex ultrasonography
C. Ankle-brachial index (Correct Answer)
D. Nerve conduction studies
E. Biopsy of tibial artery
Explanation: ***Ankle-brachial index***
- The patient's symptoms of **intermittent claudication** (leg pain with exertion relieved by rest) and risk factors (smoking, diabetes, atrial fibrillation, hypertension) are highly suggestive of **peripheral artery disease (PAD)**. The **ankle-brachial index (ABI)** is the most appropriate initial diagnostic step as it is a quick, non-invasive, and reliable test to screen for PAD by comparing blood pressure in the ankles to blood pressure in the arms.
- A **diminished pedal pulse** on the right side and **cooler, shiny, dry skin** further support the suspicion of PAD, making ABI crucial for confirming the diagnosis and assessing its severity.
*MRI spine screening*
- While spinal pathology can cause leg pain, symptoms like **neurogenic claudication** typically improve with leaning forward or sitting and are not consistently relieved by standing still. The patient's pain relief with rest after walking points away from spinal stenosis.
- The patient's specific peripheral signs like a **cooler leg**, **diminished pedal pulses**, and **trophic changes** are not typical findings for spinal compression.
*Duplex ultrasonography*
- **Duplex ultrasonography** is a more advanced imaging technique used to visualize the blood vessels and assess blood flow, typically performed *after* an abnormal ABI confirms the presence of PAD.
- It helps in **localizing stenoses** and assessing their severity, but it is not the primary diagnostic screening tool in the initial evaluation of suspected PAD.
*Nerve conduction studies*
- **Nerve conduction studies (NCS)** are used to diagnose neuropathies. While diabetes is a risk factor for neuropathy, the patient's symptoms are classic for **vascular claudication** (pain with exertion, relieved by rest), rather than neuropathic pain, which is often described as burning, tingling, or numbing and does not typically resolve promptly with rest.
- The physical exam findings of a **cool leg** and **diminished pulses** are not consistent with a primary neurological problem.
*Biopsy of tibial artery*
- A **biopsy of the tibial artery** is an invasive procedure generally reserved for specific types of vasculitis (e.g., giant cell arteritis, polyarteritis nodosa) when other less invasive diagnostics have been inconclusive or raised suspicion for these conditions.
- It is not indicated for the initial workup of suspected **atherosclerotic peripheral artery disease**, which is the most likely diagnosis given the patient's risk factors and symptoms.
Question 1149: A 68-year-old woman comes to the physician for a follow-up visit for elevated blood pressure. Two weeks ago, her blood pressure was 154/78 mm Hg at a routine visit. Subsequent home blood pressure measurements at days 5, 10, and 14 have been: 156/76 mm Hg, 158/80 mm Hg, and 160/80 mm Hg. She has trouble falling asleep but otherwise feels well. She had a cold that resolved with over-the-counter medication 2 weeks ago. She has a history of primary hypothyroidism and a cyst in the right kidney, which was found incidentally 20 years ago. She takes levothyroxine. She is 178 cm (5 ft 10 in) tall and weighs 67 kg (148 lb); BMI is 21.3 kg/m2. Her pulse is 82/min, and blood pressure is 162/79 mm Hg. Examination shows no abnormalities. Laboratory studies, including thyroid function studies, serum electrolytes, and serum creatinine, are within normal limits. Which of the following is the most likely underlying cause of this patient's blood pressure findings?
A. Medication-induced vasoconstriction
B. Decrease in baroreceptor sensitivity
C. Increase in kidney size
D. Increase in aldosterone production
E. Decrease in arterial compliance (Correct Answer)
Explanation: ***Decrease in arterial compliance***
- As individuals **age**, the large elastic arteries become stiffer and less compliant due to changes in **collagen and elastin**, leading to an increase in **systolic blood pressure** and pulse pressure. This patient's blood pressure readings consistently show elevated systolic pressure without other identifiable causes.
- The patient's age (68 years old) and the absence of other specific causes for secondary hypertension, combined with an isolated **systolic hypertension**, strongly suggest age-related decrease in arterial compliance as the underlying mechanism.
*Medication-induced vasoconstriction*
- While certain over-the-counter medications like **decongestants (e.g., pseudoephedrine)** can cause vasoconstriction and elevate blood pressure, the patient's cold resolved two weeks ago, making it unlikely to be a persistent cause of her current blood pressure readings.
- There is no mention of her currently taking any medications known to cause vasoconstriction beyond the short-term use for her cold, which should have resolved.
*Decrease in baroreceptor sensitivity*
- **Baroreceptor sensitivity** can decrease with age, leading to impaired short-term blood pressure regulation and an increased risk of orthostatic hypotension, but it does not directly cause sustained **essential hypertension** or primarily elevated systolic pressure in this manner.
- While decreased baroreflex sensitivity is common in the elderly, it is not the primary mechanism behind the patient's sustained high systolic blood pressure; rather, it relates more to blood pressure variability and postural changes.
*Increase in kidney size*
- An **increase in kidney size** is not typically associated with hypertension; rather, conditions like polycystic kidney disease, which causes renal enlargement, can cause hypertension through **renal ischemia** and **RAAS activation**, but the patient has a single simple cyst and normal renal function.
- The patient's history of a simple renal cyst and normal renal function tests do not suggest any kidney-related pathology causing hypertension.
*Increase in aldosterone production*
- An **increase in aldosterone production** (primary hyperaldosteronism) typically causes **hypertension** along with **hypokalemia**, which is not present in this patient as her serum electrolytes are normal.
- Primary hyperaldosteronism would likely present with **resistant hypertension** and often **metabolic alkalosis**, none of which are indicated by the patient's symptoms or laboratory findings.
Question 1150: A 58-year-old woman presents to the physician with a throbbing headache. She says she had it for the last year and it’s usually located in the right temporal area. There is localized tenderness over the scalp. During the last 2 weeks, she experienced 3 episodes of transient loss of vision on the right side, without ocular pain. On physical examination, her vital signs are normal. Palpation reveals that the pulsations of the superficial temporal artery on the right side are reduced in amplitude. Laboratory studies show:
Blood hemoglobin 10.7 g/dL (6.64 mmol/L)
Leukocyte count 8,000/mm3 (8.0 x 109/L)
Platelet count 470,000/mm3 (470 x 109/L)
Erythrocyte sedimentation rate 60 mm/h (60 mm/h)
Which of the following conditions is most likely to co-exist with the presenting complaint in this woman?
A. Amyloidosis
B. Sjogren’s syndrome
C. Fibromyalgia
D. Polymyalgia rheumatica (Correct Answer)
E. Dermatomyositis
Explanation: ***Polymyalgia rheumatica***
- This patient's symptoms are highly suggestive of **giant cell arteritis** (temporal arteritis) due to the throbbing headache, temporal tenderness, reduced temporal artery pulsation, **amaurosis fugax**, and elevated ESR.
- **Polymyalgia rheumatica** is closely associated with giant cell arteritis, often co-existing in up to 50% of patients. Both conditions are characterized by systemic inflammation.
*Amyloidosis*
- **Amyloidosis** is a disorder caused by the deposition of abnormal proteins in various tissues, leading to organ dysfunction.
- It does not typically present with the acute inflammatory symptoms or vascular complications seen in this patient, and there is no direct link to giant cell arteritis.
*Sjogren’s syndrome*
- **Sjogren's syndrome** is an autoimmune disease primarily affecting the **exocrine glands**, leading to dry eyes and dry mouth.
- While it can cause systemic symptoms, it does not typically manifest with temporal arteritis or its specific visual and cranial symptoms.
*Fibromyalgia*
- **Fibromyalgia** is a chronic condition characterized by widespread musculoskeletal pain, fatigue, and sleep disturbances, often without clear inflammation markers.
- It is not associated with giant cell arteritis or the inflammatory markers (high ESR) and vascular occlusion symptoms (amaurosis fugax) seen in this patient.
*Dermatomyositis*
- **Dermatomyositis** is an inflammatory myopathy characterized by muscle weakness and distinctive skin rashes.
- While it is an inflammatory condition, it does not typically present with the specific headache, temporal artery abnormalities, or visual symptoms that are hallmarks of giant cell arteritis.