UPSC-CMS 2020 - Pathology PYQs Practice Questions

Q: The most common site for osteosarcoma is:

Distal femur. ***Distal femur*** - The **distal femur** is the most frequent site of involvement for **osteosarcoma**, accounting for approximately 40% of all cases [1]. - This region, along with the proximal tibia and proximal humerus, constitutes the most common locations for this primary malignant bone tumor [1]. *Proximal humerus* - While the **proximal humerus** is a common site for osteosarcoma, it is less frequent than the distal femur [1]. - It ranks third in incidence after the distal femur and proximal tibia [1]. *Proximal femur* - The **proximal femur** can be affected by osteosarcoma, but it is a relatively less common site compared to the distal femur. - Osteosarcomas tend to occur around the **growth plates** of long bones [1]. *Distal humerus* - The **distal humerus** is an uncommon site for the development of osteosarcoma. - It is much less frequently involved than the other major long bone metaphyses. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Bones, Joints, and Soft Tissue Tumors, pp. 1200-1202. [Practice more Pathology PYQs on OnCourse]

Question 1

All of the following are major subtypes of breast cancer based on Gene array analysis EXCEPT:

Accepted Answer

Estrogen receptor positive

Answer

Luminal A and Luminal B

Answer

Triple negative

Answer

Her-2 receptor positive

Question 2

The most common site for osteosarcoma is:

Accepted Answer

Distal femur

Answer

Proximal humerus

Answer

Proximal femur

Answer

Distal humerus

UPSC-CMS 2020 — Pathology