UPSC-CMS 2017 Practice Questions

Q: A 28 year old P1L1 presents with severe pain in her abdomen and is taken for laparotomy. On opening the abdomen pseudomyxoma peritonei is present. What should be the probable reason?

Mucinous cystadenoma of ovary. ***Mucinous cystadenoma of ovary*** - **Pseudomyxoma peritonei** is most frequently caused by the rupture of a low-grade mucinous tumor, often originating from the **appendix** or, less commonly, the **ovary**. - A **mucinous cystadenoma of the ovary**, upon rupture, can release mucinous material into the peritoneal cavity, leading to the characteristic "jelly belly" appearance. *Rupture of dermoid tumor* - Rupture of a **dermoid tumor** (mature cystic teratoma) can cause **chemical peritonitis** due to the release of sebaceous material and hair, but it does not typically lead to pseudomyxoma peritonei. - The contents of a dermoid tumor are usually **fatty** or **keratinous**, not mucinous. *Endometriosis* - **Endometriosis** involves endometrial-like tissue growing outside the uterus, causing pelvic pain and adhesions. - It does not involve the production of a large volume of mucinous material and is therefore not a cause of pseudomyxoma peritonei. *Serous cystadenoma of ovary* - A ruptured **serous cystadenoma** would release serous (watery) fluid, not mucinous material. - While it can cause ascites, it does not produce the characteristic thick, gelatinous material seen in pseudomyxoma peritonei.

Q: A seven year old girl with precocious puberty is found to be having a 10 cm ovarian cyst on USG. The most likely etiology is

Granulosa cell tumour. ***Granulosa cell tumour*** - This tumor is a common cause of **sexual precocity** in girls because it produces **estrogen**, leading to premature development of secondary sexual characteristics. - Granulosa cell tumors can grow to a significant size, like the **10 cm ovarian cyst** described, and are often malignant or borderline. *Choriocarcinoma* - Ovarian choriocarcinoma is a **highly malignant germ cell tumor** that typically secretes **human chorionic gonadotropin (hCG)**, not estrogen. - While it can cause precocious pseudopuberty by stimulating ovarian steroidogenesis through hCG, it is a very rare primary ovarian tumor. *Benign cystic teratoma* - These are **common germ cell tumors** that contain tissues from all three germ layers; however, they are usually **hormonally inactive** and do not typically cause precocious puberty. - While they can form large cysts, the presence of precocious puberty points away from this diagnosis. *Brenner tumour* - **Brenner tumors** are uncommon epithelial ovarian tumors that are typically **solid and benign**, though malignant forms exist. - They are generally **hormonally inactive** and do not cause precocious puberty; they also typically occur in older women.

Q: A 17 year old girl presents with an ovarian cyst of 5cm. The cyst is echo free, unilocular and CA 125 of 8U/ml. What is most appropriate management?

Conservative with follow up ultrasound. ***Conservative with follow up ultrasound*** - A 5cm **unilocular, echo-free ovarian cyst** in a 17-year-old with a normal **CA-125** (8 U/mL is well within the normal range, typically <35 U/mL) is highly suggestive of a **benign functional cyst**. - Expectant management with **serial ultrasound follow-up** is the most appropriate initial approach, as these cysts often resolve spontaneously. *Laparoscopy for cyst removal* - This is an **invasive procedure** that is not indicated for a likely benign, asymptomatic ovarian cyst, especially given the young age of the patient. - Surgical intervention would only be considered if the cyst persists, grows significantly, causes symptoms, or shows suspicious features on imaging. *Laparotomy for cyst removal* - **Laparotomy** is an even more invasive surgical approach than laparoscopy, involving a larger incision, and is reserved for cases where malignancy is strongly suspected or for very large, complex cysts that cannot be removed laparoscopically. - Given the benign characteristics of the cyst, this approach is unwarranted. *Medical treatment* - There is **no specific medical treatment** (e.g., medication) that effectively resolves functional ovarian cysts. - While hormonal contraceptives can sometimes suppress the formation of new functional cysts, they do not typically treat an existing one of this nature.

Q: Most probable cause of heavy bleeding in a P2L2 during tenth day post partum is:

Retained bits of cotyledons and membranes. ***Retained bits of cotyledons and membranes*** - **Retained placental fragments** prevent the uterus from contracting effectively, leading to uterine atony and heavy bleeding. - This typically presents as secondary postpartum hemorrhage, which occurs **24 hours to 6 weeks postpartum**, consistent with bleeding on the tenth day. *Infected episiotomy wound* - An infected episiotomy wound would primarily cause **local pain**, **swelling**, **redness**, and **purulent discharge**, not heavy uterine bleeding. - While infection can exacerbate pain and discomfort, it does not directly lead to **prolonged or excessive uterine hemorrhage**. *Resumption of menstruation* - Menstruation typically resumes much later postpartum, especially in breastfeeding individuals, often **months after delivery**. - Bleeding on the tenth day is likely related to the **postpartum state** and not a return to normal menstrual cycles. *Subinvolution of placental site* - Subinvolution refers to the failure of the uterus to return to its normal size and state, which can cause **prolonged lochia** and bleeding. - While a possible cause of later postpartum bleeding, **retained placental tissue** is a more direct and common cause for significant hemorrhage on the tenth day.

Q: Combined contraceptive pills give protection from the following EXCEPT:

Cancer of cervix. ***Cancer of cervix*** - Combined oral contraceptives (COCs) do not protect against **cervical cancer**; in fact, long-term use is associated with a slightly **increased risk**, potentially due to increased exposure to **HPV** or hormonal effects on the cervix. - The primary protection against cervical cancer is **HPV vaccination** and regular **cervical screening** (Pap smears). *Cancer of endometrium* - COCs provide significant protection against **endometrial cancer** by causing endometrial atrophy and suppressing cell proliferation, which mitigates the risk posed by unopposed estrogen. - This protective effect is observed even after discontinuing COCs. *Cancer of ovary* - COCs significantly reduce the risk of **ovarian cancer**, particularly epithelial ovarian cancer, through the suppression of ovulation. - The protective effect increases with the duration of COC use and can persist for many years after discontinuation. *Ectopic pregnancy* - COCs are highly effective in preventing **pregnancy** altogether, thereby drastically reducing the risk of both uterine and **ectopic pregnancies**. - While not 100% effective, their contraceptive action makes ectopic pregnancy very rare in users compared to non-users.

Q: A woman presents with heavy foul smelling discharge with sharply demarcated ulcers without induration on the perineum and the labia majora. Inguinal lymphadenopathy is also present. What is the most probable diagnosis?

Chancroid. ***Chancroid*** - The presence of **heavy, foul-smelling discharge** with **sharply demarcated, painful ulcers** that are **not indurated** on the perineum and labia majora, along with **inguinal lymphadenopathy**, is highly characteristic of chancroid, caused by *Haemophilus ducreyi*. - The **lack of induration** and the **painful nature** of the ulcers are key differentiating features from syphilis (painless chancre with induration). - The **tender inguinal lymphadenopathy** can progress to form suppurative buboes, which is pathognomonic for chancroid. *Tuberculosis* - While tuberculosis can cause genital ulcers, they are typically **chronic, painless**, and often associated with systemic symptoms like weight loss and night sweats, which are not described here. - Genital tuberculosis is less likely to present with acute, foul-smelling discharge and sharply demarcated, non-indurated ulcers with prominent lymphadenopathy in this manner. *Trichomoniasis* - Trichomoniasis causes a **frothy, yellowish-green, foul-smelling vaginal discharge** and can lead to **vaginal irritation** and sometimes "strawberry cervix," but it **does not cause discrete ulcers** on the perineum or labia majora. - This is primarily a vaginitis caused by *Trichomonas vaginalis*, not an ulcerative condition. - Inguinal lymphadenopathy is not a feature of trichomoniasis. *Gonorrhoea* - Gonorrhoea usually presents with a **purulent vaginal or cervical discharge**, dysuria, and pelvic pain in women, but it **does not typically cause ulcers** on the perineum or labia. - This is a mucosal infection affecting the endocervix primarily, not causing ulcerative lesions. - While disseminated gonococcal infection can occur, the predominant presenting feature of ulcers points away from gonorrhoea.

Q: Absolute contraindication to combined oral contraceptive is:

History of thrombo-embolism. ***History of thrombo-embolism*** - A history of **thromboembolism** (e.g., DVT, pulmonary embolism) is an **absolute contraindication** to combined oral contraceptives (COCs) due to the increased risk of further thrombotic events associated with estrogen. - COCs, particularly their estrogen component, can increase levels of clotting factors and decrease natural anticoagulants, significantly raising the risk of **venous thromboembolism (VTE)**. *History of gallbladder disease* - A history of **gallbladder disease** is generally considered a **relative contraindication** rather than an absolute one for COCs. - While COCs may exacerbate pre-existing gallbladder conditions or increase the risk of gallstone formation in some individuals, it doesn't preclude their use in all cases. *History of GDM* - A history of **gestational diabetes mellitus (GDM)** is a **relative contraindication** or caution for COC use, particularly in women with additional risk factors for diabetes. - While COCs can affect glucose tolerance, they are not absolutely contraindicated unless the woman has developed overt diabetes or has poorly controlled metabolic issues. *History of previous two caesarean section* - A history of previous **two cesarean sections** is **not a contraindication** to combined oral contraceptive use. - This obstetric history does not impact the metabolic or thrombotic risks associated with COCs, and thus, does not directly interact with their safety profile.

Q: A woman with which of the following health problems should avoid centchroman?

Woman with dysfunctional uterine bleeding. ***Woman with dysfunctional uterine bleeding*** *(Marked as official answer, but medically questionable)* - **Important Note:** Centchroman (Ormeloxifene) is actually **approved for treating DUB** in India and is commonly used for this indication. - Its **anti-estrogenic effect on the endometrium** helps reduce abnormal bleeding by preventing excessive proliferation. - This PYQ answer may reflect specific exam context or outdated understanding, but current medical practice uses centchroman **as a treatment for DUB**, not as a contraindication. - Students should be aware this contradicts standard therapeutic use. *Polycystic ovarian syndrome* - Centchroman is **not contraindicated** in PCOS and is sometimes used for contraception in PCOS patients. - It doesn't worsen insulin resistance and may help manage endometrial effects of unopposed estrogen. - Its anti-estrogenic effects can be beneficial in preventing endometrial hyperplasia. *Endometriosis* - Centchroman is **not contraindicated** in endometriosis. - Its **anti-estrogenic action** could theoretically reduce estrogen-dependent growth of endometrial implants. - However, progestins and GnRH agonists are preferred first-line treatments. *Endometrial hyperplasia* - Centchroman has **anti-estrogenic effects on the endometrium**, making it potentially **beneficial** rather than contraindicated. - It inhibits estrogenic stimulation and promotes endometrial shedding. - May actually be used to prevent or treat endometrial hyperplasia. **Clinical Note:** None of the listed options represent absolute contraindications to centchroman. True contraindications include pregnancy, breastfeeding, hormone-dependent cancers, and severe hepatic/renal disease.

Question 1

A 28 year old P1L1 presents with severe pain in her abdomen and is taken for laparotomy. On opening the abdomen pseudomyxoma peritonei is present. What should be the probable reason?

Accepted Answer

Mucinous cystadenoma of ovary

Answer

Rupture of dermoid tumor

Answer

Endometriosis

Answer

Serous cystadenoma of ovary

Question 2

In a 40 year old woman, pap smear shows atypical glandular cells. The next step of management should be:

Accepted Answer

Colposcopy, cervical biopsy, endocervical curettage and endometrial biopsy

Answer

Hysteroscopy and directed endometrial biopsy

Answer

Colposcopic directed cervical biopsy

Answer

Repeat pap smear after three months

Question 3

A 50 year old P4L4 has a simple left ovarian cyst of 10cm. Ca 125 is 30u/ml. Treatment of choice would be:

Accepted Answer

Laparoscopic bilateral oophorectomy (BSO)

Answer

Medical management with oral contraceptives

Answer

Laparoscopic cystectomy

Answer

TAH + BSO (Total abdominal hysterectomy + Bilateral salpingo-oophorectomy)

Question 4

A seven year old girl with precocious puberty is found to be having a 10 cm ovarian cyst on USG. The most likely etiology is

Accepted Answer

Granulosa cell tumour

Answer

Choriocarcinoma

Answer

Benign cystic teratoma

Answer

Brenner tumour

Question 5

A 17 year old girl presents with an ovarian cyst of 5cm. The cyst is echo free, unilocular and CA 125 of 8U/ml. What is most appropriate management?

Accepted Answer

Conservative with follow up ultrasound

Answer

Laparoscopy for cyst removal

Answer

Laparotomy for cyst removal

Answer

Medical treatment

Question 6

Most probable cause of heavy bleeding in a P2L2 during tenth day post partum is:

Accepted Answer

Retained bits of cotyledons and membranes

Answer

Infected episiotomy wound

Answer

Resumption of menstruation

Answer

Subinvolution of placental site

Question 7

Combined contraceptive pills give protection from the following EXCEPT:

Accepted Answer

Cancer of cervix

Answer

Cancer of endometrium

Answer

Cancer of ovary

Answer

Ectopic pregnancy

Question 8

A woman presents with heavy foul smelling discharge with sharply demarcated ulcers without induration on the perineum and the labia majora. Inguinal lymphadenopathy is also present. What is the most probable diagnosis?

Accepted Answer

Chancroid

Answer

Tuberculosis

Answer

Trichomoniasis

Answer

Gonorrhoea

Question 9

Absolute contraindication to combined oral contraceptive is:

Accepted Answer

History of thrombo-embolism

Answer

History of gallbladder disease

Answer

History of GDM

Answer

History of previous two caesarean section

Question 10

A woman with which of the following health problems should avoid centchroman?

Accepted Answer

Woman with dysfunctional uterine bleeding

Answer

Polycystic ovarian syndrome

Answer

Endometriosis

Answer

Endometrial hyperplasia

UPSC-CMS 2017

Obstetrics and Gynecology

Pharmacology