NEET-PG 2017 Practice Questions

Q: All investigations are useful in work up of this condition except:

Invertogram at 24 hours. ***Urine for meconium particles*** - **Urine for meconium particles** is actually a valuable and standard investigation in **anorectal malformations** to detect **rectourinary fistulas**. - The presence of meconium in urine indicates a **communication between the rectum and urinary tract**, which is crucial information for surgical planning and management. *Invertogram at 24 hours* - An **invertogram** is a plain X-ray taken with the infant inverted for 3-5 minutes, allowing gas in the rectum to rise to the highest point. - This helps determine the **level of rectal pouch termination** relative to the **pubococcygeal line**, which is essential for distinguishing between high and low anorectal malformations. *Ultrasound* - **Perineal ultrasound** can assess the **perineal body thickness**, presence of a **rectal pouch**, and help visualize **fistulous connections**. - It is particularly useful in **real-time assessment** of the anatomy and can identify associated **genitourinary anomalies** commonly seen with anorectal malformations. *Lateral pelvic radiography* - A **lateral pelvic radiograph** provides information about the **sacral anatomy** and helps assess the **level of anorectal malformation**. - It is crucial for identifying associated **sacral anomalies** (sacral dysgenesis, hemisacrum) which occur in up to 60% of patients with anorectal malformations and affect surgical outcomes.

Q: A 2-day-old neonate under phototherapy unit. For exchange transfusion serum bilirubin-albumin ratio should be: (Recent NEET Pattern 2016-17)

$>3.5$. ***$>3.5$*** - A **serum bilirubin-albumin ratio greater than 3.5** is a common guideline indicating the need for exchange transfusion in neonates, especially those at high risk or with rapidly rising bilirubin levels. - This ratio helps assess the risk of **bilirubin-induced neurotoxicity (kernicterus)**, as unbound (free) bilirubin can cross the blood-brain barrier [1]. *$ 35$* - A serum bilirubin-albumin ratio of **greater than 35** would represent an extremely high and clinically improbable value. - Clinically, the bilirubin-albumin ratio is typically used with values in the single digits, making a value of 35 or higher incongruent with standard medical guidelines. *$<35$* - While technically true that $<35$ would include the correct threshold, it is not sufficiently specific to denote the critical value for exchange transfusion. - This range is too broad and does not pinpoint the specific bilirubin-albumin ratio that prompts intervention.

Q: Which of the following infections in most commonly seen in this transfusion dependant child shown below?

Yersinia enterocolitica. ***Yersinia enterocolitica*** - Transfusion-dependent patients, especially those with **iron overload** (common in thalassemia), are particularly susceptible to **Yersinia enterocolitica** infections because *Yersinia* thrives in iron-rich environments. - The image shows a child with marked hepatosplenomegaly (outlined on the abdomen), which is characteristic of conditions leading to transfusion dependence and subsequent iron overload, such as **thalassemia major**. *Listeria monocytogenes* - While *Listeria* can cause serious infections, particularly in immunocompromised individuals and neonates, its association with **iron overload** from transfusions is not as prominent as *Yersinia*. - **Listeriosis** typically presents as meningitis, sepsis, or febrile gastroenteritis. *Acinetobacter* - *Acinetobacter* species are often associated with **nosocomial infections**, affecting critically ill or immunocompromised patients in hospital settings, but not specifically linked to iron overload or transfusion dependence as a primary risk factor like *Yersinia*. - Infections commonly include pneumonia, urinary tract infections, and wound infections. *Pneumococcus* - **Pneumococcal infections** are common in children, especially those with asplenia or functional asplenia (which can occur in thalassemia due to splenic sequestration), but a direct link to **transfusion-associated iron overload** as a specific risk factor for severe pneumococcal disease is not the primary association like *Yersinia*. - These infections typically manifest as pneumonia, meningitis, and otitis media.

Q: Child has not passed stool by 2nd day of life. X-Ray study done shows:

Duodenal atresia. ***Duodenal atresia*** - The abdominal X-ray images display the classic **"double bubble sign"**, which is highly characteristic of duodenal atresia. This sign consists of two distinct air-filled loops, one representing the distended stomach and the other the dilated proximal duodenum, with no distal gas. - The clinical presentation of a neonate not passing stool by the second day of life, combined with the characteristic radiological findings, points directly to an **upper gastrointestinal obstruction** like duodenal atresia. *Cystic fibrosis* - While cystic fibrosis can cause **meconium ileus** leading to intestinal obstruction in newborns, it typically presents with diffuse intestinal distension rather than the localized "double bubble" pattern. - Meconium ileus on X-ray would show numerous dilated loops of small bowel with a **"ground-glass" appearance** due to trapped meconium, not the distinct two bubbles seen here. *CHPS* - **Congenital hypertrophic pyloric stenosis (CHPS)** typically manifests later, between 3-6 weeks of age, with projectile non-bilious vomiting, not as early as the second day of life with findings of intestinal obstruction on X-ray. - The X-ray findings in CHPS would show a **distended stomach but without the second bubble** representing a dilated duodenum often seen in duodenal atresia. *Anorectal malformation* - **Anorectal malformations** are lower gastrointestinal obstructions, meaning a significant portion of the bowel would be distended with gas, and the X-ray would not show the isolated "double bubble" sign. - Diagnosis is often made by physical examination demonstrating an **imperforate anus** or abnormal anal opening, in conjunction with plain abdominal radiographs that would show distal intestinal obstruction.

Q: A neonate presents with the clinical features shown in the image below. What is the most likely diagnosis?

Congenital hypothyroidism. ***Congenital hypothyroidism*** - The image shows a neonate with **macroglossia** (large tongue), **umbilical hernia**, and possibly **puffy eyelids** and **dull facies**, all characteristic signs of congenital hypothyroidism. - Other features often include **hypotonia**, **feeding difficulties**, **prolonged jaundice**, and **constipation**. *Down syndrome* - While Down syndrome can present with **hypotonia** and some shared features, the characteristic **epicanthal folds**, **simian crease**, **brushfield spots**, and flattened facial profile are not clearly evident. - Macroglossia is common but other features like an umbilical hernia would be less specific. *Ellis-Van Creveld syndrome* - This syndrome is characterized by **chondroectodermal dysplasia**, typically presenting with **polydactyly**, **short-limbed dwarfism**, **nail dysplasia**, and **cardiac defects**. - These distinct skeletal and ectodermal abnormalities are not visible in the presented image. *Turner syndrome* - Turner syndrome (XO karyotype) primarily affects females and is characterized by **short stature**, **webbed neck**, **lymphedema of hands and feet**, and **cardiac anomalies** (e.g., coarctation of the aorta). - The features shown in the image, such as macroglossia and umbilical hernia, are not typical of Turner syndrome.

Q: A newborn presents with macrosomia, plethoric appearance, and generalized edema. The image shows:

Infant of diabetic mother. ***Infant of diabetic mother*** - The image shows a **macrosomic** infant with a **plethoric appearance**, generalized **edema**, and a **"cherubic" facial appearance** with a prominent philtrum and perioral cyanosis, all characteristic features of an infant of a diabetic mother. - Maternal diabetes leads to fetal **hyperinsulinemia**, resulting in increased fat deposition, organomegaly, and altered growth patterns. *Achondroplasia* - Achondroplasia is characterized by **proximal limb shortening** (rhizomelia), a large head with a prominent forehead, and a flattened nasal bridge. - The pictured infant does not show these specific skeletal dysplasias. *Hemi-hypertrophy* - Hemi-hypertrophy involves **asymmetric growth**, where one side or part of the body is significantly larger than the other. - The infant in the image exhibits generalized, symmetrical macrosomia rather than unilateral overgrowth. *Albright hereditary osteodystrophy* - Albright hereditary osteodystrophy is a genetic disorder associated with short stature, **obesity**, brachydactyly (short digits), and typically presents with features related to **pseudohypoparathyroidism** (e.g., hypocalcemia, hyperphosphatemia). - The characteristic findings of this syndrome, such as brachydactyly, are not evident in the image.

Q: All are true about the swelling on scalp of a 2-day old neonate except: (Recent NEET Pattern 2016-17)

Heals from periphery. ***Heals from periphery*** - This is the **INCORRECT statement** about cephalohematoma in a neonate - Cephalohematomas do NOT heal from the periphery like a skin wound - Instead, the blood clot gradually **liquefies and is reabsorbed** over weeks to months (typically 2-3 months) - Resorption occurs uniformly or may even start centrally, not from the edges - This is the **exception** among the given statements *Sub-periosteal bleeding with gradual hardening* - This accurately describes **cephalohematoma**, a common birth injury - It is a **subperiosteal collection of blood** confined by suture lines - The blood undergoes **organization and calcification** over time, leading to gradual hardening - A bony rim may be palpable at the edges after 2-3 weeks *Can lead to prolongation of physiological Jaundice* - Breakdown of red blood cells within the cephalohematoma releases **bilirubin** - This increased bilirubin load can contribute to **prolonged physiological jaundice** - The large blood collection acts as an extravascular source of bilirubin *Painless* - Cephalohematoma is generally **painless** to touch for the neonate - Unlike caput succedaneum or infections, the blood collection does not cause acute pain - The swelling may appear large but is not tender

Q: Which of the following interventions is being done in this neonate?

Nasal CPAP and orogastric tube to decompress stomach. ***Nasal CPAP and orogastric tube to decompress stomach*** - The image shows a neonate with a device inserted into the nostrils for **nasal continuous positive airway pressure (nCPAP)**, used to support breathing. - Additionally, a tube is visible in the neonate's mouth leading to the stomach, which is an **orogastric (OG) tube** used for feeding or stomach decompression, especially important when using CPAP as air can be swallowed. *Positive pressure ventilation and NG tube to decompress stomach* - This option refers to positive pressure ventilation, which typically involves an **endotracheal tube** or mask/bag, neither of which is clearly depicted as the primary respiratory support. - An **NG tube (nasogastric tube)** would be inserted through the nose, but the tube shown for gastric access is in the mouth (orogastric). *Surfactant therapy and NG tube to decompress stomach* - **Surfactant therapy** is administered directly into the lungs, usually via an endotracheal tube, and is not a visible intervention in the image itself. - As noted previously, the tube for gastric decompression appears to be **orogastric**, not nasogastric. *Oxygen hood* - An **oxygen hood** is a clear plastic dome placed over the neonate's head to deliver oxygen, which is not what is shown in the image. - The visible tubes are for respiratory support and gastric access, indicating a more direct and invasive form of intervention than an oxygen hood.

Q: Identify the condition on the basis of infantogram shown in the image:

Congenital diaphragmatic hernia. ***Congenital diaphragmatic hernia*** - The infantogram shows loops of **bowel within the thoracic cavity**, displacing the heart and mediastinum. - This classic appearance, with visible **gas-filled loops** in the chest, is characteristic of a congenital diaphragmatic hernia, typically on the left side (Bochdalek hernia). *Cystic adenomatoid malformation* - This condition involves an abnormal growth of lung tissue forming **cysts**; these cysts typically appear as discrete radiolucencies or a solid mass within the lung. - Unlike in the image, it does not typically show distinct **bowel loops in the chest cavity**. *Pneumomediastinum* - This condition is characterized by air in the **mediastinum**, which would appear as lucency outlining the mediastinal structures, such as the heart and great vessels. - It does not involve the presence of **abdominal contents** within the chest cavity. *Congenital lobar emphysema* - This condition presents with **hyperinflation of a single lobe** (usually left upper lobe) causing mass effect and mediastinal shift. - It appears as a hyperlucent, overexpanded lobe, but does not show **bowel gas pattern** or abdominal contents in the thorax.

Question 1

All investigations are useful in work up of this condition except:

Accepted Answer

Invertogram at 24 hours

Answer

Urine for meconium particles

Answer

Ultrasound

Answer

Lateral pelvic radiography

Question 2

A 2-day-old neonate under phototherapy unit. For exchange transfusion serum bilirubin-albumin ratio should be: (Recent NEET Pattern 2016-17)

Accepted Answer

$>3.5$

Answer

$<3.5$

Answer

$>35$

Answer

$<35$

Question 3

Which of the following infections in most commonly seen in this transfusion dependant child shown below?

Accepted Answer

Yersinia enterocolitica

Answer

Listeria monocytogenes

Answer

Acinetobacter

Answer

Pneumococcus

Question 4

A 3-year-old child has presented with abdominal lump and peculiar appearance of eyes. All genes are responsible for development of this condition except:

Accepted Answer

K-ras gene

Answer

WT1

Answer

P53

Answer

Beta-catenin

Question 5

Child has not passed stool by 2nd day of life. X-Ray study done shows:

Accepted Answer

Duodenal atresia

Answer

Cystic fibrosis

Answer

CHPS

Answer

Anorectal malformation

Question 6

A neonate presents with the clinical features shown in the image below. What is the most likely diagnosis?

Accepted Answer

Congenital hypothyroidism

Answer

Down syndrome

Answer

Ellis-Van Creveld syndrome

Answer

Turner syndrome

Question 7

A newborn presents with macrosomia, plethoric appearance, and generalized edema. The image shows:

Accepted Answer

Infant of diabetic mother

Answer

Achondroplasia

Answer

Hemi-hypertrophy

Answer

Albright hereditary osteodystrophy

Question 8

All are true about the swelling on scalp of a 2-day old neonate except: (Recent NEET Pattern 2016-17)

Accepted Answer

Heals from periphery

Answer

Can lead to prolongation of physiological Jaundice

Answer

Painless

Answer

Sub-periosteal bleeding with gradual hardening

Question 9

Which of the following interventions is being done in this neonate?

Accepted Answer

Nasal CPAP and orogastric tube to decompress stomach

Answer

Positive pressure ventilation and NG tube to decompress stomach

Answer

Surfactant therapy and NG tube to decompress stomach

Answer

Oxygen hood

Question 10

Identify the condition on the basis of infantogram shown in the image:

Accepted Answer

Congenital diaphragmatic hernia

Answer

Cystic adenomatoid malformation

Answer

Pneumomediastinum

Answer

Congenital lobar emphysema

NEET-PG 2017

Anatomy

Internal Medicine

Pathology

Pediatrics

Radiology