Renal Pathology Practice Questions

Q: From which of the following does renal oncocytoma arise?

Collecting duct. ### Explanation **Correct Option: B. Collecting duct** Renal oncocytoma is a benign epithelial tumor that originates from the **intercalated cells of the collecting ducts**. These cells are rich in mitochondria, which gives the tumor its characteristic granular, eosinophilic cytoplasm on histopathology [1]. **Analysis of Incorrect Options:** * **A. Loop of Henle:** While various renal processes occur here, it is not the site of origin for common renal neoplasms. * **C. Proximal tubule:** This is the site of origin for **Renal Cell Carcinoma (RCC)**, specifically the **Clear Cell** and **Papillary** subtypes. This is a common distractor, as RCC is the most frequent primary renal malignancy. * **D. Bowman's capsule:** This structure is involved in filtration and is associated with crescent formation in glomerulonephritis, but not with the development of oncocytomas. **High-Yield Clinical Pearls for NEET-PG:** * **Gross Appearance:** Classically presents as a well-circumscribed, mahogany-brown tumor with a **central stellate scar**. * **Microscopy:** Composed of large cells (oncocytes) with abundant, granular, acidophilic cytoplasm. Electron microscopy reveals an **abundance of mitochondria**. * **Genetics:** Often associated with the loss of chromosomes 1 and Y. * **Differential Diagnosis:** It is difficult to distinguish from the **Chromophobe variant of RCC** (which also arises from collecting ducts) [1]. However, Chromophobe RCC typically shows "perinuclear halos" and stains positive with Hale’s Colloidal Iron, unlike oncocytoma. * **Prognosis:** Excellent, as it is a benign lesion [1]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Kidney, p. 959.

Question 1

From which of the following does renal oncocytoma arise?

Accepted Answer

Collecting duct

Answer

Loop of Henle

Answer

Proximal tubule

Answer

Bowman's capsule

Question 2

Renal papillary necrosis is seen in all of the following conditions except?

Accepted Answer

Nephrosclerosis

Answer

Diabetes mellitus

Answer

Sickle cell anemia

Answer

Anesthetic nephropathy

Question 3

Which of the following is a characteristic kidney change seen in AIDS?

Accepted Answer

Focal segmental glomerulosclerosis (FSGS)

Answer

Minimal change disease (MCD)

Answer

Membranoproliferative glomerulonephritis (MPGN)

Answer

Berger disease (IgA nephropathy)

Question 4

All the following are immune complex glomerulonephritis EXCEPT:

Accepted Answer

Good pasture's disease (RPGN)

Answer

Acute infectious glomerulonephritis

Answer

Membranous glomerulonephritis

Answer

SLE

Question 5

Which cells are primarily involved in the pathogenesis of interstitial cystitis?

Accepted Answer

Lymphocytes

Answer

Neutrophils

Answer

Macrophages

Answer

Mast cells

Question 6

A patient diagnosed with bronchiectasis 5 years ago presents with leg edema and proteinuria. What is the most likely renal finding?

Accepted Answer

Amyloid Nephropathy

Answer

Minimal Change Disease

Answer

Rapidly Progressive Glomerulonephritis (RPGN)

Answer

Crescenteric Glomerulonephritis

Question 7

Which of the following is a feature of lipoid nephrosis?

Accepted Answer

Normal on light microscopy

Answer

Epithelial deposit

Answer

Glomerular tuft sclerosis

Answer

Diffuse, uniform effacement of foot processes

Question 8

IgA nephropathy is characterized by all of the following except?

Accepted Answer

Renal biopsy showing mesangial IgA deposition

Answer

Hypertension

Answer

Hematuria

Answer

Nephritic syndrome

Question 9

Where are the deposits typically found in IgA Nephropathy?

Accepted Answer

Mesangium

Answer

Subepithelial

Answer

Subendocardial

Answer

No deposits

Question 10

Which of the following is NOT a pathological change seen in diabetic nephropathy?

Accepted Answer

Focal sclerosis

Answer

Fibrin caps and capsular drops

Answer

Intercapillary glomerulosclerosis

Answer

Capillary basement membrane thickening

Renal Pathology — MCQs

Renal Pathology — MCQs

On this page

Practice by Chapter

Want unlimited practice?