Neuropathology Practice Questions

Q: Which of the following statements is not true about Glioblastoma?

It belongs to WHO grade 3 Astrocytoma. **Explanation:** **1. Why Option C is the Correct (False) Statement:** Glioblastoma (GBM) is classified as a **WHO Grade 4** tumor, not Grade 3. It is the most aggressive and common primary malignant brain tumor in adults. According to the updated WHO classification, Grade 3 astrocytomas are termed "Anaplastic Astrocytomas." The hallmark that upgrades an astrocytoma to Grade 4 (GBM) is the presence of **necrosis** and/or **microvascular proliferation** [1]. **2. Analysis of Other Options:** * **Option A (Butterfly Tumor):** GBM frequently crosses the midline via the **corpus callosum**, involving both cerebral hemispheres. On imaging, this symmetrical spread resembles the wings of a butterfly, hence the name "Butterfly Glioma." * **Option B (Frontal Lobe):** While GBM can occur anywhere in the CNS, the **frontal and temporal lobes** are the most common supratentorial locations. * **Option D (Characteristic Features):** Histopathology of GBM is classic for **Serpentine (palisading) necrosis**, where areas of dead tissue are surrounded by crowded tumor cells, and **Glomeruloid bodies**, which are tufts of multilayered, proliferating endothelial cells resembling renal glomeruli [1]. **3. High-Yield Clinical Pearls for NEET-PG:** * **Molecular Marker:** IDH-wildtype status is now a defining feature of primary Glioblastoma in the latest WHO classification. * **Age Group:** Most common in the 5th to 7th decades of life [2]. * **Genetic Associations:** Often associated with **EGFR amplification** and PTEN mutations [2]. * **Prognosis:** Poor, despite aggressive surgery, radiotherapy, and chemotherapy (Temozolomide) [1]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Central Nervous System, pp. 1310-1311. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Central Nervous System, pp. 1308-1310.

Question 1

What is the pathological change observed in the brain in cerebral malaria?

Accepted Answer

Microvascular occlusion

Answer

Cerebral edema

Answer

Increased intracranial pressure

Answer

Space occupying lesion

Question 2

Inclusions in oligodendrocytes are a characteristic feature of which condition?

Accepted Answer

Progressive multifocal leukoencephalopathy (PML)

Answer

Creutzfeldt-Jakob disease

Answer

Chronic inflammatory demyelinating polyneuropathy (CIDP)

Answer

Herpes simplex virus (HSV) encephalitis

Question 3

Porencephaly is due to what cause?

Accepted Answer

Cerebral infarction

Answer

Dandy-Walker syndrome

Answer

Fetal alcohol syndrome

Answer

All of the above

Question 4

Which receptor on the neuronal membrane is implicated in the development of glioma?

Accepted Answer

CD-133

Answer

CD-117

Answer

CD-33

Answer

CD-45

Question 5

All of the following are congenital myopathies EXCEPT:

Accepted Answer

Mitochondrial myopathy

Answer

Nemaline myopathy

Answer

Central core disease

Answer

Centronuclear myopathy

Question 6

Which of the following is the characteristic pathological feature of Parkinson's disease?

Accepted Answer

Lewy bodies

Answer

Babes nodule

Answer

Neurofibrillary tangle

Answer

Negri bodies

Question 7

A patient presents with severe headaches, develops convulsions, and dies. Autopsy reveals the brain has a "Swiss cheese" appearance due to numerous small cysts containing milky fluid. Microscopic examination shows a scolex with hooklets within one of these cysts. What is the causative agent for this disease?

Accepted Answer

Taenia solium

Answer

Taenia saginata

Answer

Diphyllobothrium latum

Answer

Echinococcus granulosa

Question 8

Neurofibrillary tangles, senile plaques, and amyloid angiopathy are associated with which of the following causes of dementia?

Accepted Answer

Alzheimer's disease

Answer

Creutzfeldt-Jakob disease

Answer

Vascular dementia

Answer

Niemann-Pick disease

Question 9

Which of the following statements is not true about Glioblastoma?

Accepted Answer

It belongs to WHO grade 3 Astrocytoma

Answer

Also known as Butterfly tumor

Answer

Frontal lobe of the brain is a common location

Answer

Serpentine necrosis and glomeruloid bodies are characteristic features

Question 10

All of the following are true of watershed infarcts except?

Accepted Answer

Seen in subcortical white matter

Answer

Seen at the junction of major cerebral arteries

Answer

Cerebral vasospasm may cause it

Answer

Associated with hypoxic-ischemic encephalopathy

Neuropathology — MCQs

Neuropathology — MCQs

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