Cellular Pathology of the Nervous System Practice Questions

Question 1

What are Gitter cells?

Accepted Answer

Modified macrophages in the CNS

Answer

Microglia

Answer

Astrocytic cells

Answer

Oligodendrocytic cells

Question 2

Which of the following statements about peripheral nerve injury is false?

Accepted Answer

Neuropraxia is irreversible

Answer

Wallerian degeneration starts in axonotmesis

Answer

Neurotmesis is the most severe form of injury

Answer

Epineurium is intact in axonotmesis

Question 3

What is the appropriate fluid management in the case of an intracerebral hemorrhage?

Accepted Answer

Normal saline

Answer

Colloids

Answer

Blood transfusion

Answer

Hypertonic fluids

Question 4

Two or more oligoclonal bands in cerebrospinal fluid are most often positive in-

Accepted Answer

Multiple sclerosis

Answer

Acute bacterial meningitis

Answer

Subarachnoid hemorrhage

Answer

Polyneuropathy

Question 5

Irreversible cell injury is indicated by

Accepted Answer

Calcium accumulation in cells

Answer

Myelin figures

Answer

Decreased ATP levels

Answer

Loss of ribosomal attachment

Question 6

Histopathological feature of HIV encephalitis is/are-

Accepted Answer

Microglial nodules

Answer

Lewy body

Answer

Fibrillary plaque

Answer

Negri body

Question 7

What is the primary pathological mechanism in classical Guillain-Barré syndrome affecting the peripheral nervous system?

Accepted Answer

It causes demyelination of peripheral nerves.

Answer

It blocks neurotransmitter release.

Answer

It inhibits muscle contraction.

Answer

It leads to axonal degeneration.

Question 8

A child presented with microcephaly, hepatomegaly and periventricular calcification. What is the best specimen for diagnosis of CMV by PCR?

Accepted Answer

Urine

Answer

CSF

Answer

Blood

Answer

Liver biopsy

Question 9

Investigation of choice for leptomeningeal carcinomatosis:

Accepted Answer

Gd enhanced MRI

Answer

CT scan

Answer

SPECT

Answer

PET

Question 10

False regarding Alzheimer's disease (AD) is:

Accepted Answer

Extracellular inclusion (lesion) can occur in the absence of intracellular inclusions to make pathological diagnosis of AD

Answer

Number of neurofibrillary tangles is associated with the severity of dementia

Answer

Number of senile (neuritic) plaques correlates (increases) with age

Answer

Presence of tau protein suggest neurodegeneration

Cellular Pathology of the Nervous System — MCQs

Cellular Pathology of the Nervous System — MCQs

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