Neuropathology Practice Questions

Q: Which of the following is diagnostic of rabies?

Negri bodies. ***Negri bodies*** - **Negri bodies** are eosinophilic, sharply outlined, inclusion bodies found in the cytoplasm of certain nerve cells, particularly in the **hippocampus** and **Purkinje cells** of the cerebellum, in cases of rabies infection [1]. - Their presence in brain tissue is **pathognomonic** for rabies [1]. *Guarneri bodies* - **Guarneri bodies** are acidophilic cytoplasmic inclusion bodies found in cells infected with **variola (smallpox) virus** or **vaccinia virus**. - They are characteristic of poxvirus infections, not rabies. *Cowdry A body* - **Cowdry A bodies** are intranuclear inclusion bodies seen in cells infected with certain viruses like **herpes simplex virus (HSV)**, **varicella-zoster virus (VZV)**, and **cytomegalovirus (CMV)**. - They are not associated with rabies. *Bollinger bodies* - **Bollinger bodies** are eosinophilic cytoplasmic inclusion bodies primarily found in epithelial cells infected with **fowlpox virus**, a type of avian poxvirus. - They are not relevant to human rabies diagnosis. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Central Nervous System, pp. 1279-1280.

Q: Which of the following is NOT a typical pathologic feature of the brain in AIDS?

Temporal lobe infarction. ***Temporal lobe infarction*** - While infarction can occur due to various causes, **temporal lobe infarction** is not a typical or primary neuropathologic feature directly associated with HIV infection itself. - HIV-related neurological complications more commonly involve widespread inflammation, opportunistic infections, or direct neurotoxic effects, rather than focal ischemic events in the temporal lobe [1]. *Perivascular giant cell invasion* - This is a **hallmark feature of HIV encephalitis (HIVE)**, characterized by the presence of multinucleated giant cells derived from macrophages/microglia, often surrounding blood vessels [1]. - These cells are infected with HIV and contribute to the inflammatory and destructive processes in the brain, representing one of the classic pathologic findings [1]. *Microglial nodules* - **Microglial nodules** are aggregations of activated microglia and macrophages, often found within the brain parenchyma in HIV-infected individuals. - They represent a **typical inflammatory response** to HIV infection and are a characteristic feature of HIV encephalitis along with multinucleated giant cells and white matter changes. *Vasculitis* - HIV infection can occasionally cause CNS vasculitis, leading to inflammation of blood vessels in the brain. - While recognized as a potential complication, it is relatively uncommon compared to the classic triad of microglial nodules, multinucleated giant cells, and white matter pathology that define typical HIV neuropathology. **References:** [1] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Manifestations Of Central And Peripheral Nervous System Disease, pp. 711-712.

Q: All of the following hereditary conditions predispose to central nervous system tumors, except.

Xeroderma pigmentosum. ***Xeroderma pigmentosum*** - This condition primarily predisposes individuals to **skin cancers** due to defects in DNA repair mechanisms, rather than to central nervous system tumors. - **Neurological complications** can occur, but they are not associated with an increased risk of CNS tumors. *Neurofibromatosis 1 & 2* - Both types are well known for a strong association with **central nervous system tumors** [2][3], particularly **gliomas** and **meningiomas**. - Neurofibromatosis type 1 is especially linked with **optic pathway gliomas**, observable in pediatric patients. *Von-Hippel-Lindau syndrome* - This syndrome is associated with **hemangioblastomas** in the CNS [2][4], particularly in the **cerebellum** and **spinal cord** [4]. - Also predisposes to other tumors, including **renal cell carcinoma** and pancreatic neuroendocrine tumors. *Tuberous sclerosis* - Patients often develop **subependymal giant cell astrocytomas** and other brain tumors due to this condition [1][2]. - Additionally, it can lead to the formation of **hamartomas** in various organs, including the brain [1]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Central Nervous System, pp. 1318-1319. [2] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Manifestations Of Central And Peripheral Nervous System Disease, pp. 724-725. [3] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Central Nervous System, pp. 1319-1320. [4] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Manifestations Of Central And Peripheral Nervous System Disease, pp. 726-727.

Q: Brain space-occupying lesions cause death by.

Brain herniation. ***Brain herniation*** - **Brain herniation** is the ultimate cause of death in patients with space-occupying lesions because it directly compresses vital brainstem structures responsible for cardiorespiratory function [2]. - Herniation syndromes (uncal, central, tonsillar) compress the brainstem, leading to irreversible damage to autonomic regulatory centers and cardiorespiratory arrest [1], [2]. *Cushing's reflex* - **Cushing's reflex** (hypertension, bradycardia, irregular respirations) is a physiological response to increased intracranial pressure (ICP) [3]. - It is a compensatory mechanism to maintain cerebral perfusion, not the direct cause of death. - Death occurs when this protective mechanism fails and herniation supervenes [1]. *Decreased cerebral perfusion* - **Decreased cerebral perfusion** results from increased ICP exceeding cerebral perfusion pressure [3]. - While severe hypoperfusion causes brain ischemia, the immediate lethal event is **brain herniation** compressing vital brainstem structures [2]. *Cerebral edema* - **Cerebral edema** (vasogenic or cytotoxic) is a pathological consequence of space-occupying lesions that contributes to increased ICP [2]. - However, edema itself does not directly cause death; rather, it increases mass effect leading to herniation, which is the terminal event [4]. **References:** [1] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Manifestations Of Central And Peripheral Nervous System Disease, pp. 699-700. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Peripheral Nerves and Skeletal Muscles, pp. 1257-1258. [3] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Manifestations Of Central And Peripheral Nervous System Disease, pp. 698-699. [4] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Central Nervous System, pp. 1275-1276.

Q: An elderly man has become progressively unable to live independently over the past several years, requiring assistance with daily activities. He has no motor or sensory deficits on physical examination, but is unable to give the current date or state his location. At autopsy, a large superficial left parietal lobe hemorrhage is found, along with numerous neocortical neuritic plaques and neurofibrillary tangles in the brain. Which mechanism is most likely responsible for his disease?

Aggregation of Aβ peptide. ***Aggregation of Ab peptide*** - The presence of **neocortical neuritic plaques** containing **Aβ (Amyloid beta) peptides** is indicative of Alzheimer's disease, where peptide aggregation is a crucial mechanism [1,2]. - This aggregation leads to **neurodegeneration** and associated symptoms, aligning with the patient's cognitive decline and sudden coma [2]. *Dopamine deficiency* - Primarily associated with **Parkinson's disease**, which typically presents with **motor deficits** such as tremors and rigidity, unlike this patient's purely cognitive symptoms. - Dopamine deficiency does not explain the findings of **neurosenile plaques** and **tangles** in the context of an 86-year-old male. *Conformational change in the prion protein (PrP)* - This mechanism relates primarily to **prion diseases** like Creutzfeldt-Jakob disease, characterized by rapid neurological decline and distinctive histopathological findings. - There is no evidence of **prion-like degeneration** or **spongiform changes** noted in this patient's brain autopsy findings. *Expansion of polyglutamine repeats* - This is primarily associated with **Huntington's disease**, marked by **chorea and cognitive decline**, rooted in basal ganglia dysfunction, which is not applicable here. - The findings in this patient relate more to **Alzheimer's disease** pathology than polyglutamine expansion disorders. **References:** [1] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Manifestations Of Central And Peripheral Nervous System Disease, pp. 721-722. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Central Nervous System, pp. 1290-1294.

Q: Most common tumor associated with neurofibromatosis type 1?

Neurofibromas. ***Neurofibromas*** - **Neurofibromas** are pathognomonic benign peripheral nerve sheath tumors that occur in over 90% of individuals with **Neurofibromatosis type 1 (NF1)**, making them the most common associated tumor. - They can be cutaneous, subcutaneous, or plexiform, with plexiform neurofibromas having a potential for malignant transformation. *Optic glioma* - **Optic gliomas** (specifically pilocytic astrocytomas of the optic pathway) are commonly associated with NF1 and can cause visual impairment, but they are not the *most common* tumor overall. - While frequently seen, particularly in childhood NF1, the prevalence of optic gliomas is lower than that of neurofibromas. *Astrocytoma* - **Astrocytomas** are a type of glioma that can occur in NF1, including those that manifest as optic gliomas. However, astrocytoma is a broad category, and non-optic pathway astrocytomas are less common than neurofibromas. - Other forms of astrocytoma, such as high-grade gliomas, are rare but can occur in NF1 patients. *Bilateral acoustic neuroma* - **Bilateral acoustic neuromas (vestibular schwannomas)** are the hallmark tumor of **Neurofibromatosis type 2 (NF2)**, not NF1 [1]. - Their presence strongly indicates a diagnosis of NF2, which is genetically and clinically distinct from NF1.

Q: Rosenthal fibers are?

Intracytoplasmic inclusions. **Intracytoplasmic inclusions** - **Rosenthal fibers** are characteristic **intracytoplasmic inclusions** found in **astrocytes**. - They are composed of **glial fibrillary acidic protein (GFAP)** and **alpha B-crystallin**, indicating reactive astrocytosis. *Intraclear inclusions* - **Intranuclear inclusions** are found within the **nucleus**, distinct from the cytoplasm where Rosenthal fibers are located. - Examples include viral inclusions (e.g., **CMV**) or certain neurodegenerative diseases (e.g., **Huntington's disease**), which have different compositions. *Present extracellularly* - **Extracellular components** are found outside cells and include structures like collagen or amyloid plaques. - Rosenthal fibers are **cellular components**, specifically within the cytoplasm of astrocytes, not in the extracellular space. *Part of cell membrane* - The **cell membrane** is the boundary of the cell, composed of lipids and proteins. - Rosenthal fibers are **intracellular structures** involved in the cytoskeleton and stress response, not integral parts of the cell membrane itself.

Q: Which of the following statements is true regarding HSV encephalitis?

Hemorrhagic lesions are seen. ***Hemorrhagic lesions are seen*** - **Hemorrhagic necrosis** of the **temporal lobes** is the pathognomonic feature of HSV encephalitis [3] - The hemorrhagic nature helps differentiate it from other viral encephalitides - Classically affects the **medial temporal lobes** and **inferior frontal lobes** bilaterally [2] - MRI shows hemorrhagic changes with mass effect in these regions *Caused by HSV-1* - While **HSV-1** causes >90% of HSV encephalitis cases in adults and children, this statement is technically correct - However, **hemorrhagic lesions** are the more distinctive pathological feature being tested - HSV-1 is the causative agent, but the hemorrhagic pathology is the key diagnostic finding *Eosinophilic inclusion bodies are seen* - **Cowdry type A intranuclear inclusion bodies** are indeed seen in HSV encephalitis [1] - These are **eosinophilic** with a clear halo around them - While true, this is a microscopic finding, whereas hemorrhagic lesions are the macroscopic hallmark *Caused by Varicella zoster virus* - VZV causes **varicella** (chickenpox) and **herpes zoster** (shingles) [2] - VZV can cause encephalitis but with different clinical and pathological features - HSV encephalitis is specifically caused by **herpes simplex virus**, not varicella zoster virus **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Infectious Diseases, pp. 365-366. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Central Nervous System, pp. 1278-1279. [3] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Central Nervous System, p. 1278.

Q: Which of the following statements about the CSF findings in pyogenic meningitis is true?

Glucose is decreased and protein is elevated. ***Glucose is decreased and protein is elevated*** - In **pyogenic (bacterial) meningitis**, bacteria consume glucose, leading to a **decreased CSF glucose** level. [1] - The inflammatory response increases the permeability of the blood-brain barrier, allowing proteins to leak into the CSF, resulting in **elevated CSF protein**. [1] *CSF contains no organisms* - This statement is incorrect; **pyogenic meningitis** is caused by bacterial infection, and therefore, **bacteria (organisms)** are typically present in the CSF. [1] - Microscopic examination and culture of the CSF are crucial for identifying the causative organism. [1] *CSF is sterile and clear* - CSF in **pyogenic meningitis** is **not sterile** due to the presence of bacteria, and it is typically **turbid or cloudy** due to the high leukocyte count. [1] - A clear and sterile CSF would suggest the absence of bacterial infection or a very early stage of viral meningitis. [1] *Chloride is decreased and glucose is normal* - While **CSF chloride** might be slightly decreased in severe meningitis cases, it is not a primary diagnostic marker, and **glucose is typically decreased**, not normal, in pyogenic meningitis. - **Normal CSF glucose** with decreased chloride might be observed in other conditions, but not typically in established pyogenic meningitis. **References:** [1] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Manifestations Of Central And Peripheral Nervous System Disease, pp. 708-709.

Q: Which of the following best describes a type of injury that occurs after the initial head trauma?

Secondary injury (complications after initial trauma).. ***Secondary injury (complications after initial trauma)*** - **Secondary injury** describes the physiological events and processes that occur minutes to days after the initial impact, such as **ischemia**, **edema**, and inflammation [1]. - These events exacerbate the damage initiated by the primary injury and can lead to worsened neurological outcomes. *Delayed complications (e.g., ischemia, edema).* - While **ischemia** and **edema** are examples of delayed complications, the term "delayed complications" is less precise than "secondary injury" in describing the broad range of pathophysiological processes. - **Secondary injury** encompasses the various cellular and molecular cascades that follow the initial trauma [1]. *Primary injury (damage at the time of trauma).* - **Primary injury** refers to the direct damage that occurs at the exact moment of impact, such as **contusions**, **lacerations**, and **axonal shearing** [2]. - This type of injury is irreversible and cannot be prevented after the trauma has occurred. *Initial trauma (primary impact).* - **Initial trauma** or **primary impact** refers to the immediate mechanical forces applied to the head. - This phrase describes the event itself rather than the resulting biological injury. **References:** [1] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Manifestations Of Central And Peripheral Nervous System Disease, pp. 701-702. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Central Nervous System, pp. 1262-1264.

Question 1

Which of the following is diagnostic of rabies?

Accepted Answer

Negri bodies

Answer

Guarneri bodies

Answer

Cowdry A body

Answer

Bollinger bodies

Question 2

Which of the following is NOT a typical pathologic feature of the brain in AIDS?

Accepted Answer

Temporal lobe infarction

Answer

Microglial nodules

Answer

Perivascular giant cell invasion

Answer

Vasculitis

Question 3

All of the following hereditary conditions predispose to central nervous system tumors, except.

Accepted Answer

Xeroderma pigmentosum

Answer

Neurofibromatosis 1 & 2

Answer

Von-Hippel-Lindau syndrome

Answer

Tuberous sclerosis

Question 4

Brain space-occupying lesions cause death by.

Accepted Answer

Brain herniation

Answer

Cushing's reflex

Answer

Decreased cerebral perfusion

Answer

Cerebral edema

Question 5

An elderly man has become progressively unable to live independently over the past several years, requiring assistance with daily activities. He has no motor or sensory deficits on physical examination, but is unable to give the current date or state his location. At autopsy, a large superficial left parietal lobe hemorrhage is found, along with numerous neocortical neuritic plaques and neurofibrillary tangles in the brain. Which mechanism is most likely responsible for his disease?

Accepted Answer

Aggregation of Aβ peptide

Answer

Conformational change in the prion protein (PrP)

Answer

Dopamine deficiency

Answer

Expansion of polyglutamine repeats

Question 6

Most common tumor associated with neurofibromatosis type 1?

Accepted Answer

Neurofibromas

Answer

Astrocytoma

Answer

Bilateral acoustic neuroma

Answer

Optic glioma

Question 7

Rosenthal fibers are?

Accepted Answer

Intracytoplasmic inclusions

Answer

Present extracellularly

Answer

Part of cell membrane

Answer

Intranuclear inclusions

Question 8

Which of the following statements is true regarding HSV encephalitis?

Accepted Answer

Hemorrhagic lesions are seen

Answer

Caused by HSV-1

Answer

Eosinophilic inclusion bodies are seen

Answer

Caused by Varicella zoster virus

Question 9

Which of the following statements about the CSF findings in pyogenic meningitis is true?

Accepted Answer

Glucose is decreased and protein is elevated

Answer

CSF contains no organisms

Answer

CSF is sterile and clear

Answer

Chloride is decreased and glucose is normal

Question 10

Which of the following best describes a type of injury that occurs after the initial head trauma?

Accepted Answer

Secondary injury (complications after initial trauma).

Answer

Primary injury (damage at the time of trauma).

Answer

Delayed complications (e.g., ischemia, edema).

Answer

Initial trauma (primary impact).

Neuropathology — MCQs

Neuropathology — MCQs

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