Neuropathology Practice Questions

Q: In the provided histopathology image of a schwannoma, what does the arrow-marked lesion represent?

Antoni A tissue with Verocay body. ***Antoni A tissue with Verocay body*** - **Antoni A tissue** is the densely cellular component of schwannoma with **spindle-shaped Schwann cells** arranged in compact fascicles. - **Verocay bodies** are pathognomonic features consisting of **nuclear palisading** around **acellular eosinophilic zones**, exclusively found in Antoni A areas. *Rosettes* - **Rosettes** are circular arrangements of cells around a central lumen, typically seen in **ependymomas** and other CNS tumors. - They are **not characteristic** of schwannomas and represent a different histological pattern entirely. *Antoni B tissue with Verocay body* - **Antoni B tissue** consists of **loose, myxoid, hypocellular areas** with scattered Schwann cells in a mucoid matrix. - **Verocay bodies are never found** in Antoni B tissue - they are **exclusive to Antoni A areas** only. *Palisading* - **Palisading** refers to the general arrangement of nuclei in parallel rows, seen in various tumors including **glioblastoma** and **fibrous histiocytoma**. - While palisading occurs in Verocay bodies, the **complete structure** (palisading nuclei + acellular eosinophilic center) defines the **Verocay body**, not just palisading alone.

Question 1

Cerebellar hemangioblastoma and retinal tumors are seen in which of the following conditions?

Accepted Answer

Von Hippel-Lindau syndrome

Answer

Neurofibromatosis type 1

Answer

Tuberous sclerosis

Answer

Neurofibromatosis type 2

Question 2

Which is the most common type of brain tumor?

Accepted Answer

Metastatic tumors (secondaries)

Answer

Medulloblastoma

Answer

Glioblastoma

Answer

Craniopharyngioma

Question 3

Which tumor has the best prognosis?

Accepted Answer

Cerebellar astrocytoma

Answer

Ependymoma

Answer

Medulloblastoma

Answer

Glioblastoma multiforme

Question 4

Which of the following structures is most prone to hypoxic injury?

Accepted Answer

Hippocampus

Answer

Thalamus

Answer

Caudate nucleus

Answer

Cerebellum

Question 5

Elongated filaments in Pick's disease consist of?

Accepted Answer

Hyperphosphorylated tau

Answer

Ubiquitin

Answer

Alpha-synuclein

Answer

Beta-synuclein

Question 6

Which of the following will manifest as pachymeningitis haemorrhagica interna?

Accepted Answer

Subdural haematoma

Answer

Epidural haematoma

Answer

Subarachnoid haemorrhage

Answer

Brain infarction

Question 7

Onion bulb appearance on nerve biopsy is seen in which of the following conditions?

Accepted Answer

Chronic inflammatory demyelinating polyneuropathy (CIDP)

Answer

Amyloid neuropathy

Answer

Diabetic neuropathy

Answer

Leprous neuritis

Question 8

In the provided histopathology image of a schwannoma, what does the arrow-marked lesion represent?

Accepted Answer

Antoni A tissue with Verocay body

Answer

Rosettes

Answer

Antoni B tissue with Verocay body

Answer

Palisading

Question 9

Which is the most malignant primary brain tumor?

Accepted Answer

Glioblastoma multiforme

Answer

Ependymoma

Answer

Medulloblastoma

Answer

Oligodendroglioma

Question 10

An 80-year-old female presents with progressive loss of memory, difficulty in recalling names, dysphasia, and irritability. Along with neurofibrillary tangles, what other pathological finding will be found in the brain?

Accepted Answer

Beta-amyloid plaques

Answer

Ceramidase

Answer

Lewy bodies

Answer

Pick's bodies

Neuropathology — MCQs

Neuropathology — MCQs

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