Question 1

Q: A 40-year-old wom an presents with headache and undergoes evaluation for a brain tumor/ cerebellopontine angle. Histopathological examination reveals a tumor composed of Antoni A and Antoni B areas. Which of the following is the most sensitive immunohistochemical marker for this tumor?

S-100 protein. ***S-100 protein*** - S-100 is a protein expressed in cells of neural crest origin, and it serves as a highly **sensitive immunohistochemical marker** for **Schwannomas**. - The tumor described presents characteristic **Antoni A** (dense, hypercellular) and **Antoni B** (loose, hypocellular) areas, which are pathognomonic for Schwannoma. *Glial fibrillary acidic protein (GFAP)* - GFAP is an intermediate filament protein primarily found in **glial cells** like astrocytes and ependymal cells. - It is used to diagnose **gliomas** (e.g., astrocytoma, ependymoma) rather than nerve sheath tumors. *Epithelial membrane antigen (EMA)* - EMA is typically positive in **meningiomas**, which also frequently occur in the cerebellopontine angle. - While it is a useful marker in neuropathology, it is not the primary diagnostic marker for a Schwannoma. *c-KIT* - c-KIT (CD117) is the standard diagnostic marker for **gastrointestinal stromal tumors (GIST)**. - It is not a useful marker for tumors originating from Schwann cells or other neural sheath components.

Question

A 40-year-old wom an presents with headache and undergoes evaluation for a brain tumor/ cerebellopontine angle. Histopathological examination reveals a tumor composed of Antoni A and Antoni B areas. Which of the following is the most sensitive immunohistochemical marker for this tumor?

Accepted Answer

S-100 protein

Answer

Glial fibrillary acidic protein (GFAP)

Answer

Epithelial membrane antigen (EMA)

Answer

c-KIT

Neuropathology — MCQs

Neuropathology — MCQs

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