Inactivated vaccine. ***Inactivated vaccine*** - The **Salk vaccine** is an **inactivated poliovirus vaccine (IPV)** that uses chemically inactivated (killed) wild-type poliovirus strains. - This inactivation process renders the virus unable to replicate or cause disease, while still retaining its **antigenicity** to elicit an immune response. - The Salk vaccine is administered by **intramuscular injection** and provides systemic immunity. *Live vaccine* - **Live vaccines** contain live, replicating organisms that are either attenuated (weakened) or fully virulent. - The **Sabin vaccine** (oral poliovirus vaccine - OPV) is an example of a live attenuated vaccine for polio, not the Salk vaccine. - The Salk vaccine contains completely inactivated virus and is therefore not a live vaccine. *Attenuated vaccine* - **Attenuated vaccines** contain live but weakened forms of the pathogen, which can replicate to a limited extent in the host without causing disease. - Examples include MMR, varicella, and the **Sabin vaccine** for polio. - The Salk vaccine uses **inactivated virus**, not attenuated virus, making this option incorrect. *Inactivated toxin* - An **inactivated toxin**, also known as a **toxoid vaccine**, is derived from bacterial toxins that have been rendered harmless but still stimulate an immune response. - Examples include **tetanus and diphtheria vaccines**, which target bacterial toxins rather than whole viruses. - The Salk vaccine targets the **poliovirus itself**, not a toxin produced by the virus.

Vaccine and Vaccination — MCQs

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Vaccine and Vaccination — MCQs

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Principles of Immunization

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Types of Vaccines

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Vaccine Development and Production

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Routine Immunization Schedule

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Adverse Events Following Immunization

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Cold Chain and Vaccine Delivery

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New Vaccine Technologies

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Vaccination in Special Populations

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Herd Immunity and Population Protection

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Anti-vaccination Movement and Hesitancy

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National Immunization Programs

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Future of Vaccines

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