Transplantation Immunology Practice Questions

Question 1

HLA typing is useful in:

Accepted Answer

Organ transplant

Answer

Disputed paternity

Answer

Dactylography

Answer

Thanatology

Question 2

Which of the following drugs shows nephrotoxicity during administration?

Accepted Answer

Tacrolimus

Answer

Azathioprine

Answer

Mycophenolate mofetil

Answer

Leflunomide

Question 3

Which of the following statements regarding rejection of solid organ transplants is true?

Accepted Answer

Hyperacute rejection begins in the operating room with reperfusion of the transplanted organ

Answer

Most immunosuppressive medications are used to prevent chronic rejection

Answer

The major cause of graft failure is acute rejection

Answer

Liver transplants are especially susceptible to hyperacute rejection

Question 4

Hyperacute rejection occurs within:-

Accepted Answer

Minutes to hours

Answer

12 hours

Answer

24 hours

Answer

6 hours

Question 5

Most strongly associated with rheumatoid arthritis among the following is?

Accepted Answer

HLA DR4

Answer

HLA B27

Answer

HLA DQ1

Answer

HLA DR8

Question 6

Which antigen is most critical in initiating graft rejection?

Accepted Answer

HLA - Antigen

Answer

DHA

Answer

Polysaccharide

Answer

MHC - molecule

Question 7

What is the most common immunosuppressant regimen used in renal transplant for maintenance?

Accepted Answer

Calcineurin inhibitors + Purine antagonists + Glucocorticoids

Answer

Calcineurin inhibitors + Purine antagonists + Basliximab

Answer

Glucocorticoids + Cyclophosphamide

Answer

Cyclophosphamide + Purine antagonists + Glucocorticoids

Question 8

Cell surface molecules involved in peripheral tolerance induction are

Accepted Answer

B7 and CD28

Answer

CD40 and CD40L

Answer

CD34 and CD51

Answer

B7 and CD3

Question 9

What is the most common type of graft rejection?

Accepted Answer

Acute

Answer

Hyperacute

Answer

Chronic

Answer

Acute on chronic

Question 10

Which of the following is a cause of post-transplantation hypertension? I. Rejection II. Cyclosporine nephrotoxicity III. Renal transplant artery stenosis (RTAS) IV. Recurrent disease in the allograft. Select the correct option.

Accepted Answer

All of the options are correct causes of post-transplantation hypertension.

Answer

None of the above are correct causes.

Answer

I, II, and IV are correct causes.

Answer

I and III are correct causes.

Transplantation Immunology — MCQs

Transplantation Immunology — MCQs

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