Venerology — MCQs

Venerology Indian Medical PG Practice Questions and MCQs

Question 241: A 58-year-old male presents with chronic genital ulceration, inguinal lymphadenopathy, and foul-smelling discharge. A biopsy shows granulomatous inflammation with Donovan bodies. Analyze and determine the most appropriate treatment.

A. Azithromycin 1g orally once a week for 3 weeks
B. Ceftriaxone 250mg IM once
C. Penicillin G 2.4 million units IM once
D. Doxycycline 100mg orally BID for 21 days (Correct Answer)

Explanation: ***Doxycycline 100mg orally BID for 21 days*** - This regimen is the **recommended treatment** for **donovanosis (granuloma inguinale)**, characterized by chronic genital ulcers and the presence of **Donovan bodies**. - **Doxycycline** targets the causative organism, *Klebsiella granulomatis*, effectively resolving the infection. *Azithromycin 1g orally once a week for 3 weeks* - While azithromycin is used for some sexually transmitted infections, the **weekly dosing** for donovanosis is typically **1g once weekly for at least 3 weeks**, but **doxycycline** is generally preferred for initial treatment. - This regimen is sometimes used as an alternative, but continuous daily dosing of **doxycycline** is often more effective in achieving sustained therapeutic levels. *Ceftriaxone 250mg IM once* - **Ceftriaxone** [1] is the standard treatment for **gonorrhea** and is often used in combination with azithromycin for suspected chlamydial coinfection. - It is **not effective** against *Klebsiella granulomatis* and therefore would not treat donovanosis. *Penicillin G 2.4 million units IM once* - This is the standard treatment for primary, secondary, and early latent **syphilis**. - **Penicillin G** does not have activity against *Klebsiella granulomatis* and would be ineffective for donovanosis.

Question 242: A 25-year-old male with a history of unprotected sex presents with dysuria, urethral discharge, and conjunctivitis. Laboratory results show a negative gram stain, and NAAT is pending. What is the next best step in management?

A. Delay treatment until NAAT results are available
B. Topical antibiotics for conjunctivitis only
C. Penicillin G intramuscularly for suspected gonorrhea
D. Empiric treatment with ceftriaxone and azithromycin for suspected gonococcal and chlamydial infections (Correct Answer)

Explanation: ***Empiric treatment with ceftriaxone and azithromycin for suspected gonococcal and chlamydial infections*** - This patient's symptoms (dysuria, urethral discharge, conjunctivitis, history of unprotected sex) are highly suggestive of a sexually transmitted infection, specifically **gonorrhea** and **chlamydia**, which often co-occur [1]. - Due to the potential for serious complications and the high likelihood of infection, **empiric treatment** covering both common pathogens is warranted while awaiting NAAT results. *Delay treatment until NAAT results are available* - Delaying treatment can lead to **progression of the infection**, increasing the risk of complications such as epididymitis, pelvic inflammatory disease, or disseminated gonococcal infection [1]. - The patient's symptoms are acute and indicate active infection, requiring prompt intervention. *Topical antibiotics for conjunctivitis only* - While topical antibiotics might address the conjunctivitis symptomatically, they would **not treat the underlying urethral infection** or prevent its complications. - **Ocular involvement in STIs** (e.g., gonococcal conjunctivitis) often requires systemic treatment in addition to topical therapy. *Penicillin G intramuscularly for suspected gonorrhea* - **Penicillin G is not the recommended first-line treatment for gonorrhea** due to widespread resistance; **ceftriaxone** is the current recommendation [1]. - This option also **fails to address potential co-infection with chlamydia**, which is common and requires a different antibiotic (e.g., azithromycin).

Question 243: Which of the following is a common clinical manifestation of secondary syphilis?

A. Chancre
B. Maculopapular rash (Correct Answer)
C. Gummas
D. Aortic aneurysm

Explanation: **Maculopapular rash** - The **maculopapular rash** of secondary syphilis is highly characteristic, often affecting the **palms and soles**, and can be widespread [1]. - This rash results from widespread dissemination of **Treponema pallidum** through the bloodstream [1]. *Chancre* - A **chancre** is a **painless ulcer** that is the hallmark lesion of **primary syphilis**, appearing at the site of infection [1]. - It typically heals spontaneously within 3-6 weeks, even without treatment, before secondary syphilis manifestations occur [1]. *Gummas* - **Gummas** are **granulomatous lesions** that are characteristic of **tertiary syphilis**, a late complication of untreated infection [1]. - They can affect various organs, including skin, bone, and internal organs, leading to significant tissue destruction. *Aortic aneurysm* - An **aortic aneurysm**, specifically **syphilitic aortitis**, is a serious manifestation of **tertiary syphilis**, often occurring decades after the initial infection [1]. - It results from chronic inflammation of the aortic wall, leading to weakening and dilation of the aorta.

Question 244: Which of the following conditions is not a typical feature of secondary syphilis?

A. Condyloma lata
B. Alopecia
C. Gummas (Correct Answer)
D. Maculopapular rash

Explanation: Self-Correction: Gummas are a characteristic feature of tertiary syphilis, not secondary syphilis, representing chronic granulomatous lesions. They can affect various organs, including skin, bones, and internal organs, appearing years after the initial infection. *Maculopapular rash* - A diffuse maculopapular rash, often involving the palms and soles, is a classic presentation of secondary syphilis [1]. - This rash is typically non-itchy and can vary in appearance, sometimes becoming papulosquamous [1]. *Condyloma lata* - Condyloma lata are moist, wart-like lesions that appear in intertriginous areas (e.g., genital, perianal) during secondary syphilis [1]. - These lesions are highly infectious and result from widespread spirochetemia. *Alopecia* - Patchy alopecia, often described as a "moth-eaten" appearance, can occur during secondary syphilis. - This type of hair loss is temporary and usually resolves with treatment.

Question 245: Which of the following is a hallmark of tertiary syphilis?

A. Chancre
B. Condylomata lata
C. Aortic aneurysm (Correct Answer)
D. Maculopapular rash

Explanation: ***Aortic aneurysm*** – **Aortic aneurysm** (specifically **thoracic aortic aneurysm**) is a classic manifestation of tertiary syphilis, resulting from chronic inflammation of the vasa vasorum leading to weakening of the aortic wall. – It can also manifest as **neurosyphilis** (e.g., tabes dorsalis, general paresis) or **gummas** (granulomatous lesions) affecting various organs [1]. *Chancre* – A **chancre** is a **painless ulcerative lesion** that characterizes the **primary stage** of syphilis [1]. – It typically appears at the site of infection about 3 weeks after exposure and resolves spontaneously [1]. *Condylomata lata* – **Condylomata lata** are **wart-like lesions** that appear in the **secondary stage** of syphilis, often in moist areas like the anogenital region or skin folds [1]. – They are highly infectious and contain numerous spirochetes. *Maculopapular rash* – A **maculopapular rash** is a common and distinctive feature of **secondary syphilis**, often affecting the palms and soles [1]. – This rash is typically non-itchy and can appear a few weeks to months after the chancre has resolved [1].

Question 246: What is the most appropriate treatment for a patient diagnosed with lymphogranuloma venereum?

A. Penicillin
B. Ceftriaxone
C. Doxycycline (Correct Answer)
D. Metronidazole

Explanation: ***Doxycycline*** - **Doxycycline** is the recommended first-line treatment for **lymphogranuloma venereum (LGV)** due to its effectiveness against *Chlamydia trachomatis* serovars L1, L2, and L3, which cause LGV. - Treatment typically involves a 21-day course to ensure complete eradication of the infection and resolution of symptoms like **lymphadenopathy** and **genital ulcers** [1]. *Penicillin* - **Penicillin** is primarily used to treat bacterial infections like **syphilis**, **streptococcal pharyngitis**, and certain **gonococcal infections**. - It is **ineffective** against *Chlamydia trachomatis*, the causative agent of LGV. *Ceftriaxone* - **Ceftriaxone** is a third-generation cephalosporin commonly used for treating **gonorrhea**, **meningitis**, and other severe bacterial infections [1]. - It has **poor activity** against *Chlamydia trachomatis* and is not an appropriate treatment for LGV. *Metronidazole* - **Metronidazole** is an antimicrobial highly effective against **anaerobic bacteria** and **protozoa**, commonly used for conditions like **trichomoniasis**, **bacterial vaginosis**, and **amebiasis**. - It has **no activity** against *Chlamydia trachomatis* and is therefore not used for LGV.

Question 247: A 40-year-old woman presents with a painless ulcer on her genitalia and reports a recent new sexual partner. What is the most likely diagnosis?

A. Gonorrhea
B. Chlamydia
C. Syphilis (Correct Answer)
D. Genital herpes

Explanation: Syphilis - **Primary syphilis** is characterized by a **painless chancre** (ulcer) at the site of infection [1], which typically appears 10 to 90 days after exposure. - The history of a new sexual partner increases the likelihood of acquiring a sexually transmitted infection like syphilis [2]. *Gonorrhea* - Primarily causes **urethritis** in men and **cervicitis** in women, leading to symptoms like discharge and dysuria, not typically a painless ulcer. - While it can cause pharyngitis or proctitis, a painless genital ulcer is not its classic presentation. *Chlamydia* - Often causes **asymptomatic infections** or symptoms similar to gonorrhea, such as **cervicitis** or **urethritis**, with discharge and dysuria [2]. - It does not typically present with a **painless genital ulcer**. *Genital herpes* - Characterized by **painful vesicles** and **ulcers** [3], usually preceded by prodromal symptoms like tingling or burning. - The ulcers associated with herpes are typically *painful* [4], which contrasts with the symptom presented in the question.

Question 248: A 28-year-old male presents with dysuria and purulent urethral discharge. A Gram stain reveals gram-negative diplococci. What is the most likely diagnosis?

A. Chlamydia trachomatis
B. Gonorrhea (Correct Answer)
C. Trichomoniasis
D. Syphilis

Explanation: ***Gonorrhea*** - The presence of **dysuria**, **purulent urethral discharge**, and **gram-negative diplococci** on Gram stain is the classic presentation for *Neisseria gonorrhoeae* [1]. - *Neisseria gonorrhoeae* is a **Gram-negative diplococcus** and is readily identifiable microscopically from urethral exudates in males [1]. *Chlamydia trachomatis* - While *Chlamydia trachomatis* also causes urethritis with dysuria and discharge, the discharge is typically **less purulent** or **mucopurulent**, not frankly purulent as described [1]. - *Chlamydia trachomatis* is an **intracellular bacterium** and cannot be visualized as gram-negative diplococci on a Gram stain. *Trichomoniasis* - *Trichomoniasis* is caused by the parasite *Trichomonas vaginalis* and causes urethritis, but it would not appear as **gram-negative diplococci** on Gram stain [1]. - **Urethral discharge** due to *Trichomonas vaginalis* is often frothy and green-yellow, and microscopy reveals motile trichomonads, not bacteria. *Syphilis* - **Syphilis** is caused by the spirochete *Treponema pallidum* and typically presents with a **chancre** in the primary stage, followed by diffuse rash in the secondary stage [2]. - *Treponema pallidum* is a **spirochete** and cannot be seen on Gram stain; it requires darkfield microscopy for visualization.

Question 249: Which of the following is the treatment of choice for chancroid?

A. Ceftriaxone
B. Azithromycin (Correct Answer)
C. Penicillin
D. Doxycycline

Explanation: ***Azithromycin*** - **Azithromycin** 1 gram orally in a **single dose** is a highly effective and convenient treatment for chancroid caused by *Haemophilus ducreyi*. - Its long half-life allows for single-dose administration, which improves **patient adherence** and reduces the risk of further transmission. *Ceftriaxone* - **Ceftriaxone** is primarily used to treat **gonorrhea** [1] and is also effective against other bacterial infections. While it has some activity against *Haemophilus ducreyi*, **azithromycin** or **ciprofloxacin** are generally preferred for chancroid. *Penicillin* - **Penicillin** is the cornerstone of treatment for **syphilis**, caused by *Treponema pallidum*. - It is **not effective** against *Haemophilus ducreyi*, the causative agent of chancroid. *Doxycycline* - **Doxycycline** is a broad-spectrum antibiotic used to treat various infections, including **chlamydia** and **syphilis** (as an alternative to penicillin). - It is **not the preferred first-line treatment** for chancroid; single-dose azithromycin or ceftriaxone are generally more effective.

Question 250: A neonate is diagnosed with congenital syphilis. Which serological test is the most specific for confirming the diagnosis in the mother?

A. VDRL
B. RPR
C. TPHA (Correct Answer)
D. EIA

Explanation: PH (Treponema Pallidum Hemagglutination Assay) - **TPHA** is a **treponemal-specific test** that directly detects antibodies against *Treponema pallidum*, making it highly reliable for confirming syphilis, particularly in cases of suspected congenital syphilis in the mother. - It remains positive even after treatment, indicating past or present infection, and provides a definitive confirmation absent in non-treponemal tests. *VDRL (Venereal Disease Research Laboratory)* - **VDRL** is a **non-treponemal test** that detects antibodies to cardiolipin, a lipid-like substance released from damaged host cells, and is primarily used for screening and monitoring treatment response. [1] - While useful for initial screening and assessing disease activity, it lacks the specificity for definitive confirmation since biological false positives can occur due to other conditions such as pregnancy. [1] *RPR (Rapid Plasma Reagin)* - **RPR** is also a **non-treponemal test** similar to VDRL, detecting antibodies to cardiolipin and is widely used for screening due to its ease of performance. [1] - Like VDRL, it is not specific enough for confirmation due to potential **false positives** and is mainly used for screening and monitoring treatment effectiveness. [1] *EIA (Enzyme Immunoassay)* - **EIA** can be used as either a **treponemal-specific** or **non-treponemal** test, depending on the antigens used in the assay. [1] - While some **EIAs** are highly sensitive and specific for detecting treponemal antibodies, the term "EIA" itself is too broad, and its specificity for confirmation depends entirely on the type of antigen used, requiring further clarification for definitive diagnosis over **TPHA**.

Practice by Chapter

Syphilis

Practice Questions

Gonorrhea

Practice Questions

Chlamydial Infections

Practice Questions

Chancroid and Other Genital Ulcers

Practice Questions

Genital Herpes

Practice Questions

Human Papillomavirus Infections

Practice Questions

HIV and STIs

Practice Questions

Pelvic Inflammatory Disease

Practice Questions

STI Screening and Prevention

Practice Questions

Partner Notification and Treatment

Practice Questions

Sexually Transmitted Enteric Infections

Practice Questions

Special Populations Management

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Venerology — MCQs

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