Hematology Practice Questions

Q: A patient presents with symptoms including gum hyperplasia and hepatosplenomegaly. Which subtype of acute myeloid leukemia (AML) is most likely?

Acute Myeloid Leukemia (M4). ***M4*** - Acute myeloid leukemia (AML) M4, known as **myelomonocytic leukemia**, often presents with **gum infiltration** and **hepatosplenomegaly**, indicating an aggressive disease course [1]. - The presence of monocytes leads to **extramedullary hematopoiesis**, accounting for the enlargement of organs and gum involvement. *ALL* - Acute lymphoblastic leukemia (ALL) primarily affects lymphoid tissues and typically presents with **lymphadenopathy** and **bone pain**, rather than gum infiltration. - **Hepatosplenomegaly** can occur but is not a primary feature as seen in M4. *M3* - Acute promyelocytic leukemia (M3) is characterized by the presence of **promyelocytes** and is associated with a distinct clinical spectrum, primarily related to **coagulopathy** and not gum infiltration. - While it may present with **hematological abnormalities**, gum infiltration is not a common finding. *M2* - AML M2 is classified as **acute myeloblastic leukemia** and has less frequent **gum infiltration** compared to M4 [1]. - It can also cause **hepatosplenomegaly**, but this is more common in other variants like M4 with its characteristic features.

Q: Which of the following is a poor prognostic feature of Hodgkin lymphoma?

Albumin level 10.5 gm/dl* - A **haemoglobin level > 10.5 g/dl** is considered a **favorable prognostic factor** in Hodgkin lymphoma, indicating less severe disease or bone marrow involvement. - An **anaemia** (Hb 15,000/mm3* is associated with a poorer prognosis. *Absolute lymphocyte count > 600/ul* - An **absolute lymphocyte count (ALC) > 600/ul** (or > 8% of the total WBC count) is typically considered a **favorable prognostic factor** in Hodgkin lymphoma. - **Lymphopenia** (ALC < 600/ul) is a significant **poor prognostic indicator**, reflecting impaired immune function. [1]

Question 1

A patient presents with symptoms including gum hyperplasia and hepatosplenomegaly. Which subtype of acute myeloid leukemia (AML) is most likely?

Accepted Answer

Acute Myeloid Leukemia (M4)

Answer

Acute Promyelocytic Leukemia (M3)

Answer

Acute Myeloid Leukemia (M2)

Answer

Acute Myeloid Leukemia (M1)

Question 2

Which of the following statements is MOST accurate regarding acute Immune Thrombocytopenic Purpura (ITP)?

Accepted Answer

Most children with acute ITP recover without developing chronic issues.

Answer

Viral infections can trigger acute ITP.

Answer

Diagnosis of acute ITP is based on clinical findings and exclusion of other causes.

Answer

Acute ITP is more common in children than in adults.

Question 3

Which of the following is a poor prognostic feature of Hodgkin lymphoma?

Accepted Answer

Albumin level < 4 g/dL

Answer

WBC count < 15000/mm3

Answer

Haemoglobin > 10.5 gm/dl

Answer

Absolute lymphocyte count > 600/ul

Hematology — MCQs

Hematology — MCQs

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