Clinical Manifestations and Presentation of Diseases — MCQs

Q: Which of the following is NOT a characteristic of pancreatic cholera?

Hypochlorhydria. ***Hypochlorhydria*** - Pancreatic cholera (also known as VIPoma ) is characterized by massive secretion of vasoactive intestinal peptide (VIP) , which stimulates intestinal fluid and electrolyte secretion [1]. - Unlike **gastrinomas** which cause hyperchlorhydria, VIPomas do not directly affect gastric acid secretion, so hypochlorhydria is not a typical feature. *Hypokalemia* - This is a hallmark of pancreatic cholera due to the large volume of diarrhea, leading to significant **potassium loss** in stool. - The elevated VIP levels stimulate intestinal secretion of electrolytes, including potassium. *Glucose intolerance* - VIP can stimulate **glycogenolysis** and inhibit insulin release, leading to elevated blood glucose levels. - This is a common metabolic disturbance seen in VIPoma patients. *Hypocalcemia* - Although less common than hypokalemia, VIP can significantly increase **intestinal calcium secretion**, leading to calcium loss and subsequent hypocalcemia. - This electrolyte imbalance contributes to the clinical symptoms of pancreatic cholera.

Clinical Manifestations and Presentation of Diseases — MCQs

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