Cardiology Practice Questions

Q: Most common cardiac defect in Turner syndrome

Coarctation of aorta. ***Coarctation of aorta*** - **Coarctation of the aorta** is the most frequent cardiac defect found in individuals with **Turner syndrome**, occurring in approximately 10-20% of cases [1]. - This congenital narrowing of the aorta typically presents with **hypertension in the upper extremities** and diminished or absent pulses in the lower extremities [1]. *VSD* - **Ventricular septal defects (VSDs)** are common congenital heart defects but are not the *most common* defect associated with Turner syndrome. - VSDs involve a hole in the wall separating the two lower chambers of the heart, resulting in a **left-to-right shunt**. *ASD* - **Atrial septal defects (ASDs)** are relatively common congenital heart defects but are less frequent in Turner syndrome compared to coarctation of the aorta [2]. - An ASD involves a hole in the wall separating the two upper chambers of the heart, leading to a **left-to-right shunt**. *TOF* - **Tetralogy of Fallot (TOF)** is a complex congenital heart defect involving four specific abnormalities, but it is **rarely associated with Turner syndrome**. - TOF typically presents with **cyanosis** and can be diagnosed by an abnormal heart murmur and characteristic findings on echocardiography.

Q: Which of the following is not a high-pitched heart sound?

Tumor plop sound. ***Tumor plop sound*** - This sound, often associated with a **left atrial myxoma**, is typically a **low-pitched, thudding sound** caused by the tumor prolapsing into the left ventricle during diastole. - Its **low frequency** differentiates it from other high-pitched clicks or snaps. *Mid-systolic click* - This sound is a **high-pitched** event, commonly associated with the sudden tensing of **chordae tendineae** or abnormal leaflet motion in **mitral valve prolapse** [1]. - Its high frequency is characteristic of rapid tensing of intracardiac structures. *Opening snap* - An **opening snap** is a **high-pitched** diastolic sound caused by the abrupt opening of a **stenotic mitral valve** [1]. - The sound is generated by the sudden tensing of the fused valve leaflets, which creates a sharp sound. *Pericardial friction rub* - A **pericardial friction rub** is characterized by a high-pitched, scratchy, and often **creaky sound** heard in pericarditis. - It is created as inflamed visceral and parietal pericardial layers rub against each other, producing a high-frequency sound.

Q: Wide QRS complex (≥ 0.12 seconds) can be seen in various conditions. Which of the following is least likely to present with a wide QRS complex?

Left Anterior Fascicular Block. ***Left Anterior Fascicular Block*** - While a **Left Anterior Fascicular Block (LAFB)** does affect ventricular depolarization, it typically causes a **left axis deviation** and only *slight widening* of the QRS complex, usually less than 0.12 seconds. - The delay in conduction is primarily through one of the fascicles of the left bundle branch, not the entire ventricular conduction system. *Hyperkalemia* - Severe **hyperkalemia** can significantly impair myocardial conduction, leading to a **diffuse slowing of ventricular depolarization**. - This results in a **widened QRS complex** as the potassium levels increase, along with peaked T waves and eventually sine wave patterns. *Wolf Parkinson White Syndrome* - **Wolff-Parkinson-White (WPW) syndrome** involves an **accessory pathway** that bypasses the AV node, leading to pre-excitation of the ventricles [1, 2]. - This abnormal conduction pathway results in a **short PR interval** and a **delta wave**, which combines with normal ventricular activation to produce a **wide QRS complex** [2]. *Ventricular Tachycardia* - **Ventricular tachycardia (VT)** originates in the ventricles, bypassing the normal His-Purkinje system [3]. - This abnormal ventricular activation sequence leads to a **markedly widened QRS complex** (typically > 0.12 seconds) due to slow, muscle-to-muscle conduction [3].

Q: Which of the following is least likely to be associated with broad complex tachycardia due to ventricular tachycardia?

Termination of tachycardia by carotid sinus massage. ***Termination of tachycardia by carotid sinus massage*** - **Carotid sinus massage** typically slows or terminates **supraventricular tachycardias (SVTs)** by increasing vagal tone to the AV node. - While it might occasionally slow the ventricular rate in VT (if the SA node is still firing normally), it is very **unlikely to terminate** a re-entrant ventricular tachycardia itself [2]. *Fusion beats* - These occur when an impulse from the ventricles (VT) and an impulse from the atria (often sinus) depolarize the ventricles **simultaneously**, creating a QRS complex that is a blend of the two [1]. - Their presence is a strong indicator of **ventricular tachycardia** [1]. *AV dissociation* - This refers to the atria and ventricles beating independently, where the atrial rate is usually slower than the ventricular rate in VT [1]. - It is a **hallmark sign** of ventricular tachycardia, distinguishing it from most SVTs with aberrancy [1]. *Capture beats* - A capture beat occurs when an atrial impulse (often a sinus beat) successfully conducts through the AV node and depolarizes the ventricles during VT. - This results in a **narrower QRS complex** appearing periodically within the broad complex tachycardia, providing strong evidence for VT.

Q: Which of the following is a complication of Takayasu's arteritis?

Renal hypertension. Renal hypertension - Takayasu's arteritis often causes stenosis of the renal arteries, leading to renovascular hypertension [2]. - This complication arises from the inflammatory thickening and narrowing of large arteries, including those supplying the kidneys [3]. Intimal fibrosis - While intimal fibrosis is a pathological feature seen in Takayasu's arteritis due to chronic inflammation, it is part of the disease process rather than a direct clinical complication. - The fibrosis itself contributes to the stenosis and occlusion that cause clinical complications [1], but it is not a standalone complication. Coronary aneurysm - Though Takayasu's arteritis can affect coronary arteries, it typically causes stenosis or occlusion rather than aneurysm formation. - Coronary aneurysms are more characteristic of diseases like Kawasaki disease [3]. None of the options - This option is incorrect as renal hypertension is a well-known and significant complication of Takayasu's arteritis.

Q: What is the most common cause of sudden death in patients with sarcoidosis?

Arrhythmias. ***Arrhythmias*** - **Cardiac sarcoidosis** can lead to granulomatous infiltration of the myocardium, disrupting the **cardiac conduction system**. - This disruption can result in various **arrhythmias**, including **ventricular tachycardia** and **ventricular fibrillation**, which are frequent causes of sudden cardiac death [2]. *Pneumonia* - While sarcoidosis can affect the lungs, leading to **pulmonary fibrosis** and increased susceptibility to infection, **pneumonia** is not the most common cause of sudden death in these patients. - Death from pneumonia is typically due to **respiratory failure** which is often preceded by a period of illness rather than being sudden. *Cor pulmonale* - **Cor pulmonale** (right heart failure due to lung disease) can develop in advanced pulmonary sarcoidosis due to **pulmonary hypertension**. - While a serious complication, it generally leads to a more **gradual decline** in cardiac function rather than sudden death. *Liver failure* - **Hepatic involvement** in sarcoidosis is common, with granulomas found in the liver, but **liver failure** as a direct cause of sudden death is rare [1]. - Significant liver dysfunction usually progresses over time, leading to more chronic symptoms.

Q: In Left Ventricular Hypertrophy (LVH), what is the minimum value of SV1 + RV6 in mm that suggests the presence of LVH?

35 mm. 35 mm - A combined amplitude of **SV1 + RV6 ≥ 35 mm** on an ECG is a commonly used **Sokolow-Lyon criterion** for diagnosing LVH. - This criterion demonstrates a degree of **specificity** for LVH, although its sensitivity can be limited. 25 mm - This value is **too low** and would lead to a high number of **false positives** for LVH. - While some criteria consider smaller amplitudes, **25 mm is not a standard threshold** for the Sokolow-Lyon criteria. 30 mm - This value is **below the standard threshold** for the Sokolow-Lyon criteria, potentially leading to underdiagnosis. - The accepted cut-off for **SV1 + RV6** in adults is generally higher than 30 mm. 45 mm - While a value of **45 mm** would strongly suggest LVH, it is **not the minimum threshold** for the Sokolow-Lyon criteria. - Using this higher threshold would decrease sensitivity, potentially **missing some cases** of LVH.

Q: The normal range for Ankle Brachial Pressure Index (ABI) is:

1.0-1.3 (Normal). **1.0-1.3 (Normal)** - An **ABI** value between 1.0 and 1.3 is considered the normal range, indicating adequate blood flow to the lower extremities. - This range signifies that the **blood pressure** in the ankles is similar to or slightly higher than the blood pressure in the arms, as expected in healthy individuals [1]. * >1.3 (Calcified arteries)* - An **ABI** value greater than 1.3 usually suggests **calcification** and hardening of the arteries, making them incompressible. - This high reading often occurs in patients with **diabetes** or **chronic kidney disease** and can falsely elevate the ABI, potentially masking underlying peripheral artery disease. *0.8-0.9 (Mild PAD)* - An **ABI** in this range indicates **mild peripheral artery disease (PAD)**, where there is some reduction in blood flow, but symptoms might be subtle or only present with exertion. - Patients may experience claudication, but it's typically less severe and could improve with conservative management [1]. *0.5-0.8 (Moderate PAD)* - This range suggests **moderate peripheral artery disease (PAD)**, indicating a more significant blockage or narrowing of the arteries. - Patients often experience **intermittent claudication** and may have discomfort with less strenuous activity [1].

Q: Which of the following statements about continuous murmurs is incorrect?

Seen with coarctation of aorta. ***Seen with coarctation of aorta*** - While coarctation of the aorta can produce a murmur, it is typically a **systolic ejection murmur**, not a continuous murmur [3]. - A continuous murmur implies flow throughout both systole and diastole, which is not characteristic of the pressure gradient across a coarctation. *Peaks at S2* - Continuous murmurs indeed often **peak around the second heart sound (S2)** [1] because the pressure gradient driving the flow is usually maximal during this period. - This peak intensity at S2 helps differentiate them from other types of murmurs. *Heard both in systole and diastole* - By definition, a continuous murmur is heard throughout **both systole and diastole**, without a clear break [2]. - This characteristic indicates a persistent pressure gradient allowing blood flow across a defect or vessel throughout the cardiac cycle. *Increase on squatting* - Squatting increases **venous return** and **systemic vascular resistance**, which generally intensifies most murmurs by increasing cardiac output and pressure gradients. - This maneuver is often used to assess the nature and severity of various cardiac murmurs [3], including continuous ones.

Q: LBBB is seen with all except

Hypokalemia (low potassium levels). ***Hypokalemia (low potassium levels)*** - **Hypokalemia** does not typically cause LBBB. Instead, it can lead to **QT prolongation**, **U waves**, and flattened T waves, and may predispose to arrhythmias like **torsades de pointes** [3]. - While electrolyte imbalances can affect cardiac conduction, LBBB is primarily associated with structural heart disease or conditions that directly impact the left bundle branch [1]. *Acute Myocardial Infarction (MI)* - **Acute MI**, particularly anterior or septal MIs, can damage the **left bundle branch**, leading to new-onset LBBB [2]. - New LBBB in the setting of acute MI often indicates a **large infarction** and is associated with a worse prognosis [2]. *Hyperkalemia (high potassium levels)* - **Severe hyperkalemia** can cause a variety of ECG changes, including **widening of the QRS complex**, which can mimic LBBB or lead to other intraventricular conduction delays. - As potassium levels rise, the ECG can progress from tall peaked T waves to a wide QRS, flattened P waves, and ultimately a **sine wave pattern** and asystole. *Ashman phenomenon (aberrant conduction in atrial fibrillation)* - The **Ashman phenomenon** is a form of aberrant ventricular conduction, typically seen during **atrial fibrillation**. It refers to a wide QRS complex that occurs after a short R-R interval preceded by a long R-R interval. - This phenomenon often exhibits a morphology consistent with **right bundle branch block (RBBB)**, but can occasionally present with a LBBB-like morphology due to differences in refractory periods of the bundle branches.

Question 1

Most common cardiac defect in Turner syndrome

Accepted Answer

Coarctation of aorta

Answer

VSD

Answer

ASD

Answer

TOF

Question 2

Which of the following is not a high-pitched heart sound?

Accepted Answer

Tumor plop sound

Answer

Mid-systolic click

Answer

Opening snap

Answer

Pericardial friction rub

Question 3

Wide QRS complex (≥ 0.12 seconds) can be seen in various conditions. Which of the following is least likely to present with a wide QRS complex?

Accepted Answer

Left Anterior Fascicular Block

Answer

Hyperkalemia

Answer

Wolf Parkinson White Syndrome

Answer

Ventricular Tachycardia

Question 4

Which of the following is least likely to be associated with broad complex tachycardia due to ventricular tachycardia?

Accepted Answer

Termination of tachycardia by carotid sinus massage

Answer

Fusion beats

Answer

Capture beats

Answer

AV dissociation

Question 5

Which of the following is a complication of Takayasu's arteritis?

Accepted Answer

Renal hypertension

Answer

None of the options

Answer

Intimal fibrosis

Answer

Coronary aneurysm

Question 6

What is the most common cause of sudden death in patients with sarcoidosis?

Accepted Answer

Arrhythmias

Answer

Pneumonia

Answer

Cor pulmonale

Answer

Liver failure

Question 7

In Left Ventricular Hypertrophy (LVH), what is the minimum value of SV1 + RV6 in mm that suggests the presence of LVH?

Accepted Answer

35 mm

Answer

25 mm

Answer

30 mm

Answer

45 mm

Question 8

The normal range for Ankle Brachial Pressure Index (ABI) is:

Accepted Answer

1.0-1.3 (Normal)

Answer

0.8-0.9 (Mild PAD)

Answer

0.5-0.8 (Moderate PAD)

Answer

>1.3 (Calcified arteries)

Question 9

Which of the following statements about continuous murmurs is incorrect?

Accepted Answer

Seen with coarctation of aorta

Answer

Heard both in systole and diastole

Answer

Peaks at S2

Answer

Increase on squatting

Question 10

LBBB is seen with all except

Accepted Answer

Hypokalemia (low potassium levels)

Answer

Acute Myocardial Infarction (MI)

Answer

Hyperkalemia (high potassium levels)

Answer

Ashman phenomenon (aberrant conduction in atrial fibrillation)

Cardiology — MCQs

Cardiology — MCQs

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