Cardiology — MCQs

Cardiology Indian Medical PG Practice Questions and MCQs

Question 1491: Which of the following statements about continuous murmurs is incorrect?

A. Heard both in systole and diastole
B. Seen with coarctation of aorta (Correct Answer)
C. Peaks at S2
D. Increase on squatting

Explanation: ***Seen with coarctation of aorta*** - While coarctation of the aorta can produce a murmur, it is typically a **systolic ejection murmur**, not a continuous murmur [3]. - A continuous murmur implies flow throughout both systole and diastole, which is not characteristic of the pressure gradient across a coarctation. *Peaks at S2* - Continuous murmurs indeed often **peak around the second heart sound (S2)** [1] because the pressure gradient driving the flow is usually maximal during this period. - This peak intensity at S2 helps differentiate them from other types of murmurs. *Heard both in systole and diastole* - By definition, a continuous murmur is heard throughout **both systole and diastole**, without a clear break [2]. - This characteristic indicates a persistent pressure gradient allowing blood flow across a defect or vessel throughout the cardiac cycle. *Increase on squatting* - Squatting increases **venous return** and **systemic vascular resistance**, which generally intensifies most murmurs by increasing cardiac output and pressure gradients. - This maneuver is often used to assess the nature and severity of various cardiac murmurs [3], including continuous ones.

Question 1492: What is the most common cause of sudden death in patients with sarcoidosis?

A. Pneumonia
B. Cor pulmonale
C. Liver failure
D. Arrhythmias (Correct Answer)

Explanation: ***Arrhythmias*** - **Cardiac sarcoidosis** can lead to granulomatous infiltration of the myocardium, disrupting the **cardiac conduction system**. - This disruption can result in various **arrhythmias**, including **ventricular tachycardia** and **ventricular fibrillation**, which are frequent causes of sudden cardiac death [2]. *Pneumonia* - While sarcoidosis can affect the lungs, leading to **pulmonary fibrosis** and increased susceptibility to infection, **pneumonia** is not the most common cause of sudden death in these patients. - Death from pneumonia is typically due to **respiratory failure** which is often preceded by a period of illness rather than being sudden. *Cor pulmonale* - **Cor pulmonale** (right heart failure due to lung disease) can develop in advanced pulmonary sarcoidosis due to **pulmonary hypertension**. - While a serious complication, it generally leads to a more **gradual decline** in cardiac function rather than sudden death. *Liver failure* - **Hepatic involvement** in sarcoidosis is common, with granulomas found in the liver, but **liver failure** as a direct cause of sudden death is rare [1]. - Significant liver dysfunction usually progresses over time, leading to more chronic symptoms.

Question 1493: Which of the following conditions is a known cause of Right Bundle Branch Block (RBBB)?

A. Myocardial infarction
B. Cor pulmonale (Correct Answer)
C. Normal aging process
D. Pulmonary embolism

Explanation: ### Question Which of the following conditions is a known cause of Right Bundle Branch Block (RBBB)? ### Original Explanation ***Cor pulmonale*** - **Cor pulmonale** is **right ventricular hypertrophy** with or without dilation due to pulmonary hypertension, impacting the right ventricle's conduction system and causing **RBBB** [1]. - The increased pressure and strain on the right side of the heart can damage the right bundle branch, leading to a conduction delay visible as **RBBB** on an ECG [1]. *Normal aging process* - While the **normal aging process** can lead to some degenerative changes in the heart's conduction system, it more commonly causes **Left Anterior Fascicular Block** or **Left Bundle Branch Block (LBBB)**, rather than isolated RBBB. - Significant **RBBB** in an elderly individual often points to an underlying structural or physiological cause rather than mere aging. *Pulmonary embolism* - A **pulmonary embolism** can cause acute **right ventricular strain** and dilation, which can mimic **RBBB** or cause a transient RBBB pattern [1]. - However, **RBBB** is not a direct consequence of the physical obstruction but rather an effect of the resulting **acute pulmonary hypertension** and right heart strain [2]. *Myocardial infarction* - A **myocardial infarction** affecting the **septum** or the **right ventricle** can damage the right bundle branch, leading to **RBBB**. - However, the most classic ECG finding of a myocardial infarction is **ST-segment elevation** or **new Q waves**, with **RBBB** being a potential complication rather than a direct cause [3].

Question 1494: Which of the following arrhythmias is most commonly associated with alcohol binge in alcoholics?

A. Ventricular fibrillations
B. Ventricular premature contractions
C. Atrial flutter
D. Atrial fibrillation (Correct Answer)

Explanation: ***Atrial fibrillation*** - **Atrial fibrillation** is the most common arrhythmia associated with alcohol binge, often referred to as **"holiday heart syndrome"** [1]. - Alcohol can trigger AF by affecting **autonomic tone**, causing **electrolyte imbalances**, and direct **myocardial toxicity**, leading to electrical instability in the atria. *Ventricular fibrillations* - **Ventricular fibrillation** is a life-threatening arrhythmia that leads to cardiac arrest and is typically associated with **acute myocardial infarction** or severe **structural heart disease**, not commonly alcohol binge alone [3]. - While alcohol can increase the risk of other cardiac events, VF is not the primary arrhythmia directly induced by an alcohol binge [3]. *Ventricular premature contractions* - **Ventricular premature contractions (VPCs)** are common and can be triggered by various factors including stress, caffeine, and alcohol, but they are generally benign and not the most commonly reported serious arrhythmia from alcohol binge. - While an increase in VPCs might occur, they do not carry the same clinical significance or prevalence as AF in the context of acute alcohol consumption. *Atrial flutter* - **Atrial flutter** is another atrial arrhythmia that can be seen in patients with structural heart disease or hypertension, and can be precipitated by alcohol [2]. - However, **atrial fibrillation** is far more prevalent in acute alcohol-induced arrhythmias, making it a more common association than atrial flutter [1].

Question 1495: In Left Ventricular Hypertrophy (LVH), what is the minimum value of SV1 + RV6 in mm that suggests the presence of LVH?

A. 25 mm
B. 30 mm
C. 35 mm (Correct Answer)
D. 45 mm

Explanation: 35 mm - A combined amplitude of **SV1 + RV6 ≥ 35 mm** on an ECG is a commonly used **Sokolow-Lyon criterion** for diagnosing LVH. - This criterion demonstrates a degree of **specificity** for LVH, although its sensitivity can be limited. 25 mm - This value is **too low** and would lead to a high number of **false positives** for LVH. - While some criteria consider smaller amplitudes, **25 mm is not a standard threshold** for the Sokolow-Lyon criteria. 30 mm - This value is **below the standard threshold** for the Sokolow-Lyon criteria, potentially leading to underdiagnosis. - The accepted cut-off for **SV1 + RV6** in adults is generally higher than 30 mm. 45 mm - While a value of **45 mm** would strongly suggest LVH, it is **not the minimum threshold** for the Sokolow-Lyon criteria. - Using this higher threshold would decrease sensitivity, potentially **missing some cases** of LVH.

Question 1496: Low QRS voltage on ECG indicates ?

A. Pulmonary embolism
B. Pericardial effusion (Correct Answer)
C. Cor pulmonale
D. Infective endocarditis

Explanation: ***Pericardial effusion*** - A significant **pericardial effusion** can lead to low QRS voltage on ECG because the fluid surrounding the heart acts as an electrical insulator, dampening the electrical signals [1]. - This dampening effect reduces the amplitude of the QRS complexes recorded on the electrocardiogram [1]. *Pulmonary embolism* - While pulmonary embolism can cause various ECG changes (e.g., **S1Q3T3 pattern**, right axis deviation), it typically does not directly cause low QRS voltage. - The primary hemodynamic impact is on the right side of the heart and does not involve fluid accumulation around the heart to dampen electrical signals. *Cor pulmonale* - **Cor pulmonale** is right ventricular hypertrophy secondary to lung disease; ECG usually shows signs of **right ventricular hypertrophy** (e.g., tall R waves in V1, right axis deviation). - This condition is associated with increased electrical activity in the right ventricle, generally leading to larger, not smaller, QRS complexes in relevant leads. *Infective endocarditis* - **Infective endocarditis** affects heart valves and can cause rhythm disturbances or conduction blocks due to myocardial involvement or abscess formation. - It does not directly affect the electrical conductivity of the heart in a way that would cause generalized low QRS voltage.

Question 1497: Low QRS voltage on ECG with left ventricular hypertrophy on Echocardiography suggests a diagnosis of:

A. Cardiac Amyloidosis (Correct Answer)
B. Infective endocarditis
C. Cor pulmonale
D. Pericardial effusion

Explanation: ***Cardiac Amyloidosis*** - **Low QRS voltage** on ECG despite echocardiographic evidence of **left ventricular hypertrophy** is a classic paradox seen in cardiac amyloidosis. - Amyloid deposits infiltrate the myocardium, increasing wall thickness but **reducing electrical activity transmission**. *Cor pulmonale* - Cor pulmonale involves **right ventricular hypertrophy** due to pulmonary hypertension, not primarily left ventricular hypertrophy. - While it can cause changes in ECG findings, the combination of low QRS voltage with LVH is not characteristic. *Infective endocarditis* - Infective endocarditis primarily affects heart valves and can cause vegetations, but it does not typically lead to **left ventricular hypertrophy** or **low QRS voltage** on ECG. - ECG findings in endocarditis are often related to conduction abnormalities or ischemia if embolization occurs. *Pericardial effusion* - A significant pericardial effusion can cause **low QRS voltage** on ECG due to the dampening effect of fluid around the heart [1]. - However, it does not typically cause **left ventricular hypertrophy**; rather, it can be associated with signs of tamponade or inflammation [1].

Question 1498: What is the Ankle-Brachial Pressure Index (ABPI) value that indicates imminent risk of necrosis?

A. < 0.6
B. 0.3 (critical ischemia)
C. 0.6 - 0.9 (indicates moderate arterial disease)
D. < 0.3 (Correct Answer)

Explanation: ***< 0.3*** - An **ABPI value less than 0.3** signifies **severe critical limb ischemia**, indicating a very high risk of tissue necrosis and limb loss [1]. - At this level, **resting pain** is common, and spontaneous **ulceration or gangrene** is highly probable due to severely compromised blood flow [1]. *0.3 (critical ischemia)* - While 0.3 is generally considered a range of **critical limb ischemia**, an ABPI *strictly less than 0.3* implies an even more severe and acute risk of necrosis [1]. - This value represents a significant stage of arterial disease, but slightly higher than the most imminent risk scenario where necrosis is almost guaranteed. *< 0.6* - An ABPI of **less than 0.6** indicates **moderate to severe peripheral arterial disease (PAD)**, where intermittent claudication is common [1]. - While concerning, it does not typically represent the immediate threat of tissue necrosis as values closer to 0.3 or below do. *0.6 - 0.9 (indicates moderate arterial disease)* - An **ABPI between 0.6 and 0.9** suggests **moderate peripheral arterial disease**, often associated with **claudication symptoms** on exertion [1]. - This range typically does not indicate an imminent risk of necrosis; while blood flow is reduced, it is usually sufficient to prevent tissue death at rest.

Question 1499: Which of the following is a complication of Takayasu's arteritis?

A. None of the options
B. Intimal fibrosis
C. Renal hypertension (Correct Answer)
D. Coronary aneurysm

Explanation: Renal hypertension - Takayasu's arteritis often causes stenosis of the renal arteries, leading to renovascular hypertension [2]. - This complication arises from the inflammatory thickening and narrowing of large arteries, including those supplying the kidneys [3]. Intimal fibrosis - While intimal fibrosis is a pathological feature seen in Takayasu's arteritis due to chronic inflammation, it is part of the disease process rather than a direct clinical complication. - The fibrosis itself contributes to the stenosis and occlusion that cause clinical complications [1], but it is not a standalone complication. Coronary aneurysm - Though Takayasu's arteritis can affect coronary arteries, it typically causes stenosis or occlusion rather than aneurysm formation. - Coronary aneurysms are more characteristic of diseases like Kawasaki disease [3]. None of the options - This option is incorrect as renal hypertension is a well-known and significant complication of Takayasu's arteritis.

Question 1500: The normal range for Ankle Brachial Pressure Index (ABI) is:

A. 0.8-0.9 (Mild PAD)
B. 0.5-0.8 (Moderate PAD)
C. >1.3 (Calcified arteries)
D. 1.0-1.3 (Normal) (Correct Answer)

Explanation: **1.0-1.3 (Normal)** - An **ABI** value between 1.0 and 1.3 is considered the normal range, indicating adequate blood flow to the lower extremities. - This range signifies that the **blood pressure** in the ankles is similar to or slightly higher than the blood pressure in the arms, as expected in healthy individuals [1]. * >1.3 (Calcified arteries)* - An **ABI** value greater than 1.3 usually suggests **calcification** and hardening of the arteries, making them incompressible. - This high reading often occurs in patients with **diabetes** or **chronic kidney disease** and can falsely elevate the ABI, potentially masking underlying peripheral artery disease. *0.8-0.9 (Mild PAD)* - An **ABI** in this range indicates **mild peripheral artery disease (PAD)**, where there is some reduction in blood flow, but symptoms might be subtle or only present with exertion. - Patients may experience claudication, but it's typically less severe and could improve with conservative management [1]. *0.5-0.8 (Moderate PAD)* - This range suggests **moderate peripheral artery disease (PAD)**, indicating a more significant blockage or narrowing of the arteries. - Patients often experience **intermittent claudication** and may have discomfort with less strenuous activity [1].

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Coronary Artery Disease and Angina

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Acute Coronary Syndromes

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Heart Failure

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Cardiac Arrhythmias

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Valvular Heart Diseases

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Cardiomyopathies

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Pericardial Diseases

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Congenital Heart Disease in Adults

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Hypertension and Hypertensive Emergencies

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Pulmonary Hypertension

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Non-invasive Cardiac Diagnostics

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Preventive Cardiology

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Cardiology — MCQs

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