Question 1

Q: Which one of the following is NOT true of Pyoderma gangrenosum?

Cultures often show Gram positive Staphylococci. ***Cultures often show Gram positive Staphylococci*** - Pyoderma gangrenosum is a **sterile inflammatory dermatosis**, meaning that the ulcers are not caused by bacterial infection. - While secondary infection can occur, the primary lesion itself is **non-infectious**, and therefore, routine cultures of the ulcer base would typically be negative for primary pathogens like *Staphylococci*. *It is often secondary to heightened immunological reactivity from another disease process* - Pyoderma gangrenosum is well-known for its association with underlying systemic conditions, particularly **inflammatory bowel disease**, **rheumatoid arthritis**, and certain **hematologic malignancies**. - Its pathogenesis is thought to involve **dysregulated neutrophils** and an underlying autoimmune or autoinflammatory process. *Lesions generally respond to steroids* - **Corticosteroids** are the first-line treatment for Pyoderma gangrenosum, used to reduce inflammation and promote healing. - Both topical and systemic corticosteroids, such as **prednisone**, are effective in managing the condition. *It is characterized by cutaneous ulceration with purple undermined edges* - The classic presentation of Pyoderma gangrenosum is a rapidly evolving, painful, **necrotic ulcer** with a characteristic **violaceous (purple) undermined border**. - This distinctive appearance helps differentiate it from other types of skin ulcers. [Practice more Dermatology PYQs on OnCourse]

Question

Which one of the following is NOT true of Pyoderma gangrenosum?

Accepted Answer

Cultures often show Gram positive Staphylococci

Answer

It is often secondary to heightened immunological reactivity from another disease process

Answer

Lesions generally respond to steroids

Answer

It is characterized by cutaneous ulceration with purple undermined edges

UPSC-CMS 2020 — Dermatology