UPSC-CMS 2018 - Physiology PYQs Practice Questions

Q: Consider the following hemodynamic changes occurring during pregnancy: 1. Increase in cardiac output 2. Increase in stroke volume 3. Increase in colloid oncotic pressure 4. Increase in pulse rate Which of the statements given above are correct?

1, 2 and 4. ***Correct Answer: 1, 2 and 4*** **Statement 1: Increase in cardiac output** - CORRECT - Cardiac output increases by **30-50% during pregnancy**, peaking at 28-32 weeks - This increase is driven by increased blood volume (40-50% increase), higher metabolic demands, and the need to perfuse the uteroplacental unit **Statement 2: Increase in stroke volume** - CORRECT - Stroke volume increases by **20-30% during pregnancy**, particularly in the first and second trimesters - This contributes significantly to the overall increase in cardiac output alongside increased heart rate **Statement 3: Increase in colloid oncotic pressure** - INCORRECT - Colloid oncotic pressure actually **decreases during pregnancy** from normal values of 25-28 mmHg to approximately 22-24 mmHg - This occurs due to **hemodilution** (plasma volume increases more than red cell mass) and **decreased serum albumin concentration** (dilutional hypoalbuminemia) - The reduced oncotic pressure contributes to the **increased tendency for peripheral edema** in pregnant women **Statement 4: Increase in pulse rate** - CORRECT - Heart rate increases by **10-20 beats per minute** during pregnancy - This tachycardia helps maintain adequate cardiac output to meet the increased circulatory demands of pregnancy *Incorrect Options:* *1, 3 and 4* - Statement 3 is incorrect as colloid oncotic pressure decreases, not increases *2, 3 and 4* - Statement 3 is incorrect as colloid oncotic pressure decreases during pregnancy *1, 2 and 3* - Statement 3 is incorrect; colloid oncotic pressure falls due to hemodilution and hypoalbuminemia [Practice more Physiology PYQs on OnCourse]

Q: Which of the following statements regarding β-Human chorionic Gonadotropin are NOT correct? 1. It is a glycoprotein hormone. 2. Serum levels increase in pregnancy, germ cell tumors and gestational trophoblastic disease 3. Its levels are same in single and multiple pregnancy 4. Both alpha and beta subunits are unique and not shared with other hormones Select the correct answer using the codes given below:

3 and 4. ***3 and 4*** * Statements 3 and 4 are both **incorrect** regarding β-hCG. * **Statement 3 is incorrect:** β-hCG levels are **significantly higher** in multiple pregnancies compared to singleton pregnancies. Twin pregnancies typically show 30-50% higher β-hCG levels. * **Statement 4 is incorrect:** β-hCG shares a **common alpha subunit** with FSH, LH, and TSH. Only the **beta subunit is unique** and provides diagnostic specificity. This is a key concept in understanding glycoprotein hormone structure. *1, 3 and 4* * This option incorrectly includes statement 1 as incorrect. * Statement 1 is **correct** - β-hCG is a well-established glycoprotein hormone with carbohydrate moieties attached to a protein core. * While statements 3 and 4 are indeed incorrect, including the correct statement 1 makes this option wrong. *2, 3 and 4* * This option incorrectly includes statement 2 as incorrect. * Statement 2 is **correct** - serum β-hCG levels are markedly elevated in normal pregnancy, germ cell tumors (seminomas, choriocarcinomas), and gestational trophoblastic disease (molar pregnancy). *1, 2 and 3* * This option incorrectly identifies statements 1 and 2 as incorrect when both are correct. * It also omits statement 4, which is incorrect regarding the subunit structure of β-hCG. [Practice more Physiology PYQs on OnCourse]

Question 1

Consider the following hemodynamic changes occurring during pregnancy:

1. Increase in cardiac output
2. Increase in stroke volume
3. Increase in colloid oncotic pressure
4. Increase in pulse rate
Which of the statements given above are correct?

Accepted Answer

1, 2 and 4

Answer

1, 3 and 4

Answer

2, 3 and 4

Answer

1, 2 and 3

Question 2

Which of the following statements regarding β-Human chorionic Gonadotropin are NOT correct?

1. It is a glycoprotein hormone.
2. Serum levels increase in pregnancy, germ cell tumors and gestational trophoblastic disease
3. Its levels are same in single and multiple pregnancy
4. Both alpha and beta subunits are unique and not shared with other hormones

Select the correct answer using the codes given below:

Accepted Answer

3 and 4

Answer

1, 3 and 4

Answer

2, 3 and 4

Answer

1, 2 and 3

Answer

1, 2 and 4

Answer

3 only

Question 3

Which one of the following factors is NOT involved in the pathogenesis of Systemic inflammatory response syndrome (SIRS)?

Accepted Answer

Microvascular occlusion

Answer

Free radical production

Answer

Increased cytokine production

Answer

Abnormal nitric oxide synthesis

UPSC-CMS 2018 — Physiology