UPSC-CMS 2017 — Biochemistry

Q: Consider the following statements regarding folic acid: 1. It is needed for normal development of blood cells in the marrow 2. It has a role in synthesis of nucleic acids 3. It is resistant to boiling Which of the above statements is/are correct?

1 and 2. ***1 and 2*** - **Folic acid** is a crucial coenzyme required for the synthesis of **purines** and **pyrimidines**, which are essential components of **DNA** and **RNA**. - This role in nucleic acid synthesis is vital for cell division and growth, explaining its necessity for the normal development of **blood cells** in the **bone marrow**. *1 and 3* - While folic acid is needed for normal blood cell development, it is generally **not resistant to boiling**. - Folic acid is quite **heat-sensitive** and its content can significantly decrease with cooking, especially prolonged boiling. *1 only* - Folic acid's role extends beyond just blood cell development; its involvement in nucleic acid synthesis is a fundamental biochemical function. - The synthesis of **DNA** and **RNA** is a primary reason why it's essential for rapidly dividing cells, like those in the bone marrow. *2 and 3* - Although folic acid plays a critical role in the synthesis of nucleic acids, it is **not resistant to boiling**. - Its heat-sensitive nature means that cooking methods can significantly impact the availability of **folic acid** in foods. [Practice more Biochemistry PYQs on OnCourse]

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Consider the following statements regarding folic acid: 1. It is needed for normal development of blood cells in the marrow 2. It has a role in synthesis of nucleic acids 3. It is resistant to boiling Which of the above statements is/are correct?