Anatomy
1 questionsAnterior Mediastinal nodes are included in which level of lymph nodes?
NEET-PG 2015 - Anatomy NEET-PG Practice Questions and MCQs
Question 1141: Anterior Mediastinal nodes are included in which level of lymph nodes?
- A. I
- B. V
- C. VI (Correct Answer)
- D. VII
Explanation: ***VI*** - Level VI lymph nodes are the **prevascular and retrotracheal nodes** located in the **anterior mediastinum** [1]. - According to the **IASLC (International Association for the Study of Lung Cancer)** lymph node mapping system, Level 6 nodes are specifically classified as anterior mediastinal nodes [1]. - These include nodes anterior to the superior vena cava and ascending aorta, and nodes between the trachea and esophagus [1]. *I* - Level I lymph nodes are located in the **low cervical, supraclavicular, and sternal notch** regions. - These are **extra-thoracic nodes** and not part of the mediastinal compartments. - They represent the highest mediastinal, supraclavicular, and sternal notch nodes [1]. *V* - Level V lymph nodes are the **subaortic (aortopulmonary window)** nodes [1]. - These are located in the space between the **aorta and pulmonary artery**, lateral to the ligamentum arteriosum [1]. - While mediastinal, they are specifically in the aortopulmonary window, not classified as anterior mediastinal. *VII* - Level VII lymph nodes are the **subcarinal nodes** located below the carina in the **middle mediastinum** [1]. - These nodes are positioned in the space beneath where the trachea bifurcates into the main bronchi [1]. - They are classified as middle mediastinal nodes, not anterior mediastinal nodes.
Dermatology
1 questionsAll of the following are premalignant conditions except which of the following?
NEET-PG 2015 - Dermatology NEET-PG Practice Questions and MCQs
Question 1141: All of the following are premalignant conditions except which of the following?
- A. Bowen's Disease
- B. Pyoderma Gangrenosum (Correct Answer)
- C. Xeroderma Pigmentosum
- D. Actinic Keratosis
Explanation: ***Pyoderma Gangrenosum*** - This is a **neutrophilic dermatosis** characterized by rapidly enlarging, painful ulcers with undermined, violaceous borders. It is an inflammatory condition, not premalignant. - While often associated with systemic diseases such as **inflammatory bowel disease** or **rheumatoid arthritis**, it does not inherently carry an increased risk of developing into skin cancer. *Bowen's Disease* - This is a form of **squamous cell carcinoma in situ**, meaning the cancerous cells are confined to the epidermis and have not yet invaded the dermis. - It is considered a **premalignant lesion** because it has the potential to progress to invasive squamous cell carcinoma if left untreated. *Actinic Keratosis* - These are **rough, scaly patches** on the skin caused by years of sun exposure, predominantly in fair-skinned individuals. - Actinic keratoses are considered **premalignant lesions** with a risk of transforming into invasive squamous cell carcinoma. *Xeroderma Pigmentosum* - This is a rare, **autosomal recessive genetic disorder** characterized by a defect in DNA repair mechanisms, specifically nucleotide excision repair. - Individuals with xeroderma pigmentosum have an extremely high risk of developing various **skin cancers** (basal cell carcinoma, squamous cell carcinoma, melanoma) at an early age due to their inability to repair UV-induced DNA damage.
Internal Medicine
2 questionsPseudoclaudication is caused by
CAR-T cell therapy (Chimeric Antigen Receptor T-cell therapy) is being investigated for the treatment of which malignancy?
NEET-PG 2015 - Internal Medicine NEET-PG Practice Questions and MCQs
Question 1141: Pseudoclaudication is caused by
- A. Femoral Artery stenosis
- B. Popliteal Artery stenosis
- C. Lumbar canal stenosis (Correct Answer)
- D. Radial Artery stenosis
Explanation: ***Lumbar canal stenosis*** - **Pseudoclaudication**, also known as **neurogenic claudication**, is a characteristic symptom of **lumbar canal stenosis**. - It is caused by **compression of spinal nerve roots** in the lumbar spine, leading to pain, numbness, or weakness in the legs, often exacerbated by standing or walking and relieved by sitting or stooping forward [1]. *Femoral Artery stenosis* - **Femoral artery stenosis** causes **vascular claudication**, which is pain in the leg muscles due to insufficient blood flow during exercise [2]. - Unlike pseudoclaudication, vascular claudication is typically relieved by rest and is not influenced by spinal position [2]. *Popliteal Artery stenosis* - **Popliteal artery stenosis** also leads to **vascular claudication**, presenting as calf pain during walking due to reduced blood supply to the distal leg [2]. - This condition is related to **peripheral artery disease**, distinct from neurological compression [2]. *Radial Artery stenosis* - **Radial artery stenosis** typically affects blood flow to the **hand and forearm**, potentially causing symptoms of ischemia in those areas. - It is not associated with leg pain or claudication.
Question 1142: CAR-T cell therapy (Chimeric Antigen Receptor T-cell therapy) is being investigated for the treatment of which malignancy?
- A. Acute Lymphoblastic Leukemia (Correct Answer)
- B. Renal Cell Carcinoma
- C. Pancreatic Cancer
- D. Glioblastoma Multiforme
Explanation: ***Acute Lymphoblastic Leukemia*** - **CAR T-cell therapy** has shown remarkable success, particularly in treating refractory or relapsed **B-cell acute lymphoblastic leukemia (ALL)** in children and young adults. - The therapy targets the **CD19 antigen** found on malignant B-cells, leading to their destruction by engineered T-cells. *Renal Cell Carcinoma* - While immune therapies are used for **renal cell carcinoma (RCC)**, traditional CAR T-cell therapy targeting specific antigens has not yet achieved widespread clinical success for this solid tumor. - RCC often presents with a **heterogeneous antigenic landscape**, making it challenging for single-target CAR T-cells. *Pancreatic Cancer* - **Pancreatic cancer** is a challenging malignancy due to its dense stroma and immunosuppressive microenvironment, which limits T-cell infiltration and efficacy. - CAR T-cell therapy for pancreatic cancer is still largely in **early-stage clinical trials**, facing significant hurdles in solid tumor treatment. *Glioblastoma Multiforme* - **Glioblastoma multiforme (GBM)** is an aggressive brain tumor with unique challenges for CAR T-cell therapy, including the **blood-brain barrier** and tumor heterogeneity. - Research is ongoing to develop CAR T-cells that can effectively target GBM, often using **regional delivery methods** or targeting multiple antigens.
Obstetrics and Gynecology
1 questionsWhich is false about stress urinary incontinence?
NEET-PG 2015 - Obstetrics and Gynecology NEET-PG Practice Questions and MCQs
Question 1141: Which is false about stress urinary incontinence?
- A. More common in men (Correct Answer)
- B. It is due to weakening of pelvic floor muscles
- C. Prostate surgery may be a cause
- D. It occurs during increased abdominal pressure
Explanation: ***More common in men*** - **Stress urinary incontinence (SUI)** is significantly more prevalent in **women** due to anatomical differences and factors like childbirth. - While it can occur in men, especially after prostate surgery, the overall incidence is higher in females. *It is due to weakening of pelvic floor muscles* - Weakening of the **pelvic floor muscles** is a primary cause of SUI, leading to insufficient support for the urethra and bladder neck. - This weakness compromises the ability to maintain urethral closure pressure during activity. *Prostate surgery may be a cause* - **Radical prostatectomy** for prostate cancer is a common cause of SUI in men, as it can damage the urethral sphincter. - Damage to the internal or external urethral sphincter during surgery impairs the ability to control urine flow. *It occurs during increased abdominal pressure* - SUI characteristically involves involuntary urine leakage during activities that increase **intra-abdominal pressure**, such as coughing, sneezing, laughing, or exercising. - This increased pressure overcomes the weakened urethral resistance, leading to urine loss.
Orthopaedics
1 questionsAdson's test is positive in -
NEET-PG 2015 - Orthopaedics NEET-PG Practice Questions and MCQs
Question 1141: Adson's test is positive in -
- A. Cervical rib (Correct Answer)
- B. Cervical spondylosis
- C. Cervical fracture
- D. Cervical dislocation
Explanation: ***Cervical rib*** - **Adson's test** assesses for **thoracic outlet syndrome (TOS)**, which can be caused by a cervical rib compressing the **subclavian artery** or **brachial plexus**. - A positive test occurs when the radial pulse diminishes or disappears upon specific head and arm maneuvers, indicating neurovascular compression. *Cervical spondylosis* - This condition involves **degenerative changes** in the cervical spine, such as bone spurs and disc herniation. - While it can cause neurological symptoms, it typically does not lead to a positive Adson's test, as the compression site is different from that assessed by the test. *Cervical fracture* - A cervical fracture is a **traumatic injury** to the bones of the neck. - Adson's test is not indicated for diagnosing fractures and performing it could exacerbate the injury. *Cervical dislocation* - Cervical dislocation is a severe injury where cervical vertebrae are **displaced from their normal alignment**. - Similar to fractures, Adson's test is not appropriate for diagnosing or evaluating dislocations and carries a risk of further injury.
Pediatrics
1 questionsWhich of the following urethral anomalies is the most common?
NEET-PG 2015 - Pediatrics NEET-PG Practice Questions and MCQs
Question 1141: Which of the following urethral anomalies is the most common?
- A. Hypospadias (Correct Answer)
- B. Pinhole meatus
- C. Epispadias
- D. Stricture of the urethra
Explanation: ***Hypospadias*** - **Hypospadias** is the most common urethral anomaly, occurring when the **urethral opening** is located on the underside of the penis rather than at the tip. - Its prevalence ranges from approximately **1 in 150 to 1 in 300 live male births**, making it significantly more frequent than other urethral malformations. *Pinhole meatus* - A **pinhole meatus** refers to an abnormally small urethral opening. - While it can be a component or consequence of other anomalies, it is **less common as a standalone finding** compared to hypospadias. *Epispadias* - **Epispadias** is a rare anomaly where the urethra opens on the **dorsal (top) aspect** of the penis. - Its incidence is much lower than hypospadias, estimated at **1 in 100,000 to 1 in 500,000 live births**. *Stricture of the urethra* - A **urethral stricture** is a narrowing of the urethra, often due to **scar tissue** from inflammation, trauma, or infection. - Although it can present at any age, it is more commonly an **acquired condition** rather than a congenital anomaly like hypospadias or epispadias.
Surgery
3 questionsESWL is contraindicated in which of the following stones -
Surgery for undescended testis is recommended at what age?
What is the optimal timing for administering antibiotic prophylaxis before surgery?
NEET-PG 2015 - Surgery NEET-PG Practice Questions and MCQs
Question 1141: ESWL is contraindicated in which of the following stones -
- A. Urate stones
- B. Phosphate stones
- C. Oxalate Stones
- D. Cystine stones (Correct Answer)
Explanation: ***Cysteine stones*** - **Cystine stones** are very dense and hard, making them resistant to fragmentation by the shock waves generated during **Extracorporeal Shock Wave Lithotripsy (ESWL)**. - Due to their resistance to fragmentation, ESWL is generally ineffective for cystine stones, and other treatments like **ureteroscopy** or **percutaneous nephrolithotomy (PCNL)** are often preferred. *Oxalate Stones* - **Calcium oxalate stones** are generally **amenable to ESWL** as they are effectively fragmented by shock waves. - They are the **most common type of kidney stone** and often respond well to lithotripsy. *Urate stones* - **Uric acid stones** are typically **radiolucent** but are often **well-fragmented by ESWL**. - Their non-calcium composition does not hinder the effectiveness of shock waves. *Phosphate stones* - **Struvite (magnesium ammonium phosphate) stones** and **calcium phosphate stones** generally respond well to ESWL. - While sometimes large and branched (**staghorn calculi**), the individual components are susceptible to shock wave fragmentation, though multiple sessions or adjunctive therapies might be needed.
Question 1142: Surgery for undescended testis is recommended at what age?
- A. 36 months
- B. 12 months (Correct Answer)
- C. 24 months
- D. 6 months
Explanation: ***12 months*** - **Orchiopexy** for undescended testes is generally recommended around **12 months of age** to optimize fertility and reduce cancer risk. - This timing is within the ideal surgical window of **6-18 months**, balancing the allowance for potential spontaneous descent (which rarely occurs after 6 months) with minimizing germ cell damage. - Most pediatric surgeons prefer operating around **12 months** as it provides optimal outcomes. *6 months* - While **6 months is within the acceptable surgical window** (6-18 months), most surgeons prefer waiting closer to 12 months. - Operating at 6 months is not incorrect, but waiting a few more months allows for logistical planning and ensures any late spontaneous descent has occurred. - The key is to operate **before 18 months** to preserve fertility potential. *24 months* - Delaying surgery until 24 months (2 years) **exceeds the recommended window** and increases the risk of germ cell damage and potential future infertility. - While still beneficial compared to no surgery, the ideal timing for preserving fertility and minimizing malignancy risk has passed. *36 months* - Surgery at 36 months (3 years) is considered a **significant delay** and carries higher risks for long-term complications, including reduced fertility potential and increased risk of testicular cancer. - The benefits of early intervention are largely diminished by this age, though orchiopexy is still indicated to reduce cancer risk and for cosmetic/psychological reasons.
Question 1143: What is the optimal timing for administering antibiotic prophylaxis before surgery?
- A. Immediately before induction of anesthesia
- B. 30-60 minutes before incision (Correct Answer)
- C. 2-3 hours before surgery
- D. Immediately after surgery
Explanation: ***30-60 minutes before incision*** - This is the **optimal timing** recommended by WHO, CDC, and major surgical guidelines for most commonly used prophylactic antibiotics (cefazolin, cefuroxime). - Ensures **peak tissue and serum concentrations** are achieved at the time of incision, providing maximum protection against surgical site infections. - Based on **pharmacokinetic principles**: the antibiotic must be present at bactericidal concentrations in tissues when bacterial contamination occurs. - Studies show this timing significantly reduces surgical site infection rates compared to other timings. *Immediately before induction of anesthesia* - While acceptable in some protocols, this may be too early if there is a delay between induction and incision. - Could result in **declining antibiotic levels** by the time the incision is made, especially for antibiotics with shorter half-lives. *2-3 hours before surgery* - This is **too early** for most antibiotics. - Tissue levels may have already **declined below therapeutic concentrations** by the time of incision. - Does not provide adequate protection during the critical period of bacterial contamination. *Immediately after surgery* - This is **treatment, not prophylaxis**. - Offers **no preventive benefit** against intraoperative contamination. - By this time, bacteria introduced during surgery have already adhered to tissues and begun forming biofilms.