NEET-PG 2012 Practice Questions

Q: Which of the following conditions is NOT associated with delayed dentition?

Cystic fibrosis. ***Cystic fibrosis*** - **Cystic fibrosis** primarily affects exocrine glands, leading to issues in the respiratory and digestive systems, and does not directly impact tooth development or eruption timing. - While patients with cystic fibrosis may have other oral health concerns due to medications or nutritional deficiencies, **delayed dentition** is not a characteristic feature of the condition itself. *Down syndrome* - Children with **Down syndrome** often experience generalized developmental delays, including delayed eruption of both primary and permanent teeth. - Other common oral manifestations in Down syndrome include **microdontia**, **taurodontism**, and a higher incidence of **periodontal disease**. *Congenital hypothyroidism* - **Congenital hypothyroidism** is associated with significant developmental delays, including skeletal maturation and delayed tooth eruption. - The reduced metabolic rate due to thyroid hormone deficiency impacts bone and tooth development. *Rickets* - **Rickets**, caused by a deficiency in vitamin D, calcium, or phosphate, leads to inadequate mineralization of bone and cartilage, which can affect tooth development and eruption. - Oral manifestations of rickets include **delayed tooth eruption**, enamel hypoplasia, and a higher susceptibility to dental caries.

Q: What is the first symptom of leprosy?

Decreased pain. Decreased pain - Leprosy primarily targets Schwann cells in peripheral nerves, leading to sensory loss [1]. - The sensation of pain is typically affected earliest, often presenting as areas of numbness [1]. Decreased vibration & position sense - These sensations are typically carried by larger myelinated fibers, which tend to be affected later in the disease progression of leprosy. - While eventually involved, they are not usually the first symptom of sensory loss. Decreased temperature - Temperature sensation is also an early modality affected in leprosy, as it's carried by small, unmyelinated or thinly myelinated fibers [1]. - However, pain is often cited as the very first sensory loss, even preceding temperature changes in some cases. Decreased light touch - Light touch sensation is generally an early loss, similar to pain and temperature, due to damage to nerve fibers in the skin. - But, when distinguishing the absolute first symptom, pain perception often shows impairment even before light touch in affected areas.

Q: What is true about HER2/neu overexpression in cancer?

Responds well to monoclonal antibodies. ***Responds well to monoclonal antibodies*** - HER2/neu overexpression is targeted by **monoclonal antibodies** like trastuzumab (Herceptin), improving treatment outcomes [1]. - These therapies are specifically designed to **inhibit HER2-positive** tumors, leading to better overall prognosis compared to those without such therapies [1]. *Good prognosis* - HER2/neu overexpression is generally associated with a **poor prognosis** due to increased aggressiveness of the cancer. - It correlates with **higher rates of recurrence** and metastasis compared to HER2-negative breast cancers. *Responds well to taxanes* - While taxanes are commonly used in breast cancer treatment, HER2/neu positivity does not specifically imply a good response. - Response rates may not significantly differ based on HER2 status for taxane-based therapies alone. *Seen only in breast cancer* - HER2/neu overexpression can also occur in other cancers, such as **gastric and gastroesophageal junction cancers**. - It is not exclusive to breast cancer, though it is most commonly studied in this context [1].

Q: Gold standard technique for diagnosis of endometriosis?

Laparoscopy. ***Laparoscopy*** - **Laparoscopy** allows for direct visualization of endometrial implants and enables **biopsy confirmation**, making it the gold standard. - This minimally invasive surgical procedure is crucial for diagnosing, staging, and often treating endometriosis simultaneously. *Ca 125 level* - **CA-125** is a serum marker that can be elevated in endometriosis, but it is **not specific** and can be raised in other conditions like ovarian cancer or physiologic states. - It is primarily used for monitoring treatment response or recurrence, rather than as a primary diagnostic tool. *Ultrasound* - **Transvaginal ultrasound (TVS)** can identify endometriomas (chocolate cysts) and deep infiltrating endometriosis, but it cannot reliably visualize small peritoneal implants. - While it's a good initial imaging modality, its sensitivity for diagnosing all forms of endometriosis is **limited**. *MRI* - **MRI** offers better soft tissue contrast than ultrasound and can identify deep infiltrating endometriosis and some peritoneal implants, especially those involving the bowel or bladder. - However, MRI is **more expensive** and less accessible, and it still cannot definitively rule out all small, superficial endometrial lesions without direct visualization.

Q: After chronic use of steroids severe pain in right hip with immobility is due to

Avascular necrosis. ***Avascular necrosis*** - Chronic **steroid use** is a major risk factor for avascular necrosis (AVN), particularly affecting the **femoral head** of the hip. - Reduced blood supply leads to bone death, resulting in severe pain and impaired mobility. *Perthes disease* - This is a condition of idiopathic **avascular necrosis of the femoral head** occurring in **children**, primarily between ages 4-10. - It is not associated with steroid use and typically presents in a different age group. *Hip dislocation* - Hip dislocation presents with **acute, severe pain** and an inability to bear weight or move the hip, often due to significant trauma. - While it causes immobility, it is an **acute traumatic event** rather than a chronic consequence of steroid use. *Osteoarthritis* - Osteoarthritis is a degenerative joint disease characterized by **cartilage breakdown** and joint pain that typically **worsens with activity** and improves with rest. - While chronic hip pain can be due to osteoarthritis, its direct link to steroid use for severe pain and immobility as described is less prominent than AVN.

Q: Maximum concentration of dextrose that can be given through peripheral vascular line in neonate?

12.5%. ***12.5%*** - A maximum dextrose concentration of **12.5%** can typically be administered safely via a **peripheral intravenous line** in neonates. - Higher concentrations risk causing **osmotic damage** to the peripheral vein, leading to **phlebitis** and **thrombosis**. *5%* - While safe, a **5% dextrose** solution may not provide adequate caloric support for many neonates, especially those requiring significant nutritional intake. - It is used for basic hydration and to prevent hypoglycemia but often needs supplementation or higher concentrations for sustained feeding. *10%* - A **10% dextrose** solution is commonly used in neonates via peripheral lines, but concentrations up to 12.5% are generally considered the safe upper limit for extended use. - Exceeding 10% can increase the risk of phlebitis, although it is less severe than with 25%. *25%* - A **25% dextrose** concentration is highly hypertonic and should **never be administered through a peripheral line** in neonates due to the high risk of severe **phlebitis**, **vein damage**, and even **tissue necrosis** if extravasation occurs. - Such high concentrations require a **central venous catheter**.

Q: Newborn can be given breast milk after how much time following normal delivery?

1 hour. ***1 hour*** - Initiating breastfeeding **within 1 hour** after a normal vaginal delivery is the **WHO and UNICEF recommended standard** for optimal newborn care. - This practice, often called the **"golden hour"**, allows the newborn to benefit from **colostrum** (rich in antibodies and nutrients), promotes **mother-infant bonding**, and helps stimulate **uterine contractions** to reduce postpartum hemorrhage. - Early initiation within this timeframe supports **successful establishment of breastfeeding** and improves exclusive breastfeeding rates. *Half hour* - While initiating breastfeeding within 30 minutes is **excellent and encouraged**, the standard guideline allows up to 1 hour. - Immediate or very early feeding (within 30 minutes) is ideal when mother and baby are stable, but the flexibility up to 1 hour accommodates immediate postpartum care needs. *2 hours* - Delaying breastfeeding until 2 hours post-delivery **exceeds the recommended window** and can lead to the infant becoming **less alert** and less interested in feeding. - This delay is associated with **lower rates of successful exclusive breastfeeding** and may impact milk supply establishment. *3 hours* - A 3-hour delay in initiating breastfeeding is **significantly beyond recommended guidelines** after a normal, uncomplicated delivery. - Such delays can contribute to **poor latch**, **infant fatigue**, increased **formula supplementation**, and may hinder **long-term breastfeeding success**.

Q: What is the correct sequence of medication administration for pre-operative prophylaxis in pheochromocytoma?

Alpha blockade followed by beta blockade. ***Alpha blockade followed by beta blockade*** - **Alpha blockade** should always be initiated first to control **hypertension** and prevent a **hypertensive crisis** during surgery. This is critical because pheochromocytoma causes excessive catecholamine release, leading to profound vasoconstriction. - **Beta blockade** is then added only after adequate alpha blockade has been achieved to control **tachycardia** and arrhythmias, preventing **unopposed alpha-adrenergic stimulation** which could paradoxically worsen hypertension. *Simultaneous alpha and beta blockade* - Administering both simultaneously is dangerous because **beta blockade** can mask the effects of inadequate alpha blockade. - This can lead to **unopposed alpha-adrenergic stimulation** after beta blockade, causing severe **vasoconstriction** and hypertensive crisis. *Beta blockade followed by alpha blockade* - Initiating with **beta blockade** without prior **alpha blockade** is absolutely contraindicated in pheochromocytoma. - This can lead to severe and potentially fatal **hypertension** due to **unopposed alpha-adrenergic stimulation** as beta blockade prevents vasodilation. *Alpha blockade only* - While essential for initial management, **alpha blockade alone** might not fully control all symptoms, especially **tachycardia** and **arrhythmias** caused by high circulating catecholamine levels. - Adding a **beta blocker** after achieving adequate alpha blockade helps in controlling these cardiac effects, optimizing patient preparation for surgery.

Q: What is the type of Intussusception that is most frequently observed?

Ileocolic type. ***Ileocolic type*** - This is the **most common form of intussusception**, accounting for approximately 75% to 90% of cases, especially in children. - It occurs when the **ileum telescopes into the colon** at the ileocecal valve. *Ileoileal type* - This type involves the **invagination of one part of the ileum into another part of the ileum**. - While it can occur, it is **less common than ileocolic intussusception** and is more often associated with a pathological lead point in older children and adults. *Colo-colic type* - This involves the **telescoping of one segment of the colon into another segment of the colon**. - It is **rare in children** and, when present, is almost always associated with a pathological lead point, such as a polyp or tumor, primarily in adults. *Caeco-colic type* - This type occurs when the **cecum telescopes into the ascending colon**. - It is also a **relatively uncommon form of intussusception** compared to the ileocolic type.

Question 1

Which of the following conditions is NOT associated with delayed dentition?

Accepted Answer

Cystic fibrosis

Answer

Down syndrome

Answer

Congenital hypothyroidism

Answer

Rickets

Question 2

What is the first symptom of leprosy?

Accepted Answer

Decreased pain

Answer

Decreased vibration & position sense

Answer

Decreased temperature

Answer

Decreased light touch

Question 3

What is true about HER2/neu overexpression in cancer?

Accepted Answer

Responds well to monoclonal antibodies

Answer

Good prognosis

Answer

Responds well to taxanes

Answer

Seen in various cancers, including breast cancer

Question 4

Gold standard technique for diagnosis of endometriosis?

Accepted Answer

Laparoscopy

Answer

Ca 125 level

Answer

Ultrasound

Answer

MRI

Question 5

After chronic use of steroids severe pain in right hip with immobility is due to

Accepted Answer

Avascular necrosis

Answer

Perthes disease

Answer

Hip dislocation

Answer

Osteoarthritis

Question 6

Volkmann's contracture: which artery is involved in this condition?

Accepted Answer

Brachial artery

Answer

Radial

Answer

Ulnar

Answer

Anterior interosseous artery

Question 7

Maximum concentration of dextrose that can be given through peripheral vascular line in neonate?

Accepted Answer

12.5%

Answer

5%

Answer

10%

Answer

25%

Question 8

Newborn can be given breast milk after how much time following normal delivery?

Accepted Answer

1 hour

Answer

Half hour

Answer

2 hours

Answer

3 hours

Question 9

What is the correct sequence of medication administration for pre-operative prophylaxis in pheochromocytoma?

Accepted Answer

Alpha blockade followed by beta blockade

Answer

Beta blockade followed by alpha blockade

Answer

Simultaneous alpha and beta blockade

Answer

Alpha blockade only

Question 10

What is the type of Intussusception that is most frequently observed?

Accepted Answer

Ileocolic type

Answer

Ileoileal type

Answer

Colo-colic type

Answer

Caeco-colic type

NEET-PG 2012

Dental

Dermatology

Internal Medicine

Obstetrics and Gynecology

Orthopaedics

Pediatrics

Pharmacology

Surgery