Anatomy
6 questionsWhich is derived from Wolffian duct?
Anal valve is found in which part of anal canal?
In patients with penile or urethral injury, Colle's fascia prevents extravasation of urine from spreading into which anatomical space?
Which lymph nodes are involved in the lymphatic drainage of the lateral wall of the nose?
What are the main types of cells found in the cerebellar cortex?
All are lateral branches of the abdominal aorta, EXCEPT which of the following?
NEET-PG 2012 - Anatomy NEET-PG Practice Questions and MCQs
Question 71: Which is derived from Wolffian duct?
- A. Appendix of epididymis (Correct Answer)
- B. Appendix of the testis
- C. Uterine structure
- D. Hydatid of Morgagni
Explanation: The **appendix of the epididymis** is a vestigial structure directly derived from the mesonephric (Wolffian) duct in males. It is an embryological remnant of this duct, located at the head of the epididymis. *Appendix of the testis* - The **appendix of the testis** (hydatid of Morgagni) is a remnant of the paramesonephric (Müllerian) duct, not the Wolffian duct. - It is usually found on the upper pole of the testis, typically near the epididymis. *Uterine structure* - **Uterine structures** (uterus, fallopian tubes, and upper vagina) are derived from the paramesonephric (Müllerian) ducts in females [1]. - The Wolffian ducts largely regress in females due to the absence of testosterone. *Hydatid of Morgagni* - The term **hydatid of Morgagni** can refer to the appendix of the testis (Müllerian duct remnant) or, less commonly, to the appendix of the epididymis (Wolffian duct remnant). - However, in common clinical and anatomical usage, it almost exclusively refers to the **appendix of the testis**, which is a Müllerian duct derivative.
Question 72: Anal valve is found in which part of anal canal?
- A. Lower
- B. At anus
- C. Middle (Correct Answer)
- D. Upper
Explanation: ***Middle*** - The **anal valves** are crescentic folds located at the level of the **pectinate (dentate) line** in the middle portion of the anal canal. - They mark the inferior limit of the **anal columns** and form small recesses called **anal sinuses**. *Lower* - The lower part of the anal canal, below the pectinate line, is lined by **anoderm** and lacks anal valves. - This region is sensitive to pain due to somatic innervation. *At anus* - The anus refers to the external opening and perianal skin, which does not contain anal valves. - The anal canal transitions into the perianal skin at the anocutaneous line. *Upper* - The upper part of the anal canal, above the pectinate line, contains the **anal columns (columns of Morgagni)** but not the anal valves themselves, which are located at the base of these columns. - This region is lined by columnar epithelium and is relatively insensitive to pain.
Question 73: In patients with penile or urethral injury, Colle's fascia prevents extravasation of urine from spreading into which anatomical space?
- A. Superficial perineal space
- B. None of the options
- C. Ischiorectal fossa (Correct Answer)
- D. Abdomen
Explanation: ***Ischiorectal fossa*** - Colle's fascia (superficial perineal fascia) is the membranous layer that defines the boundaries of the **superficial perineal space**. - When urethral injury occurs, urine extravasates into the superficial perineal space but is **prevented from spreading laterally and posteriorly** into the ischiorectal fossa because Colle's fascia fuses with the **ischiopubic rami** laterally and the **perineal membrane** posteriorly [1]. - The ischiorectal fossa is a space lateral to the **anal canal** that is separated from the superficial perineal space by these fascial attachments. *Superficial perineal space* - This is actually the space **into which** urine extravasates when penile or urethral injury occurs, not the space that is protected from extravasation [1]. - Colle's fascia forms the inferior boundary of this space, so urine collects here rather than being prevented from entering. *Abdomen* - Colle's fascia in the perineum is continuous with **Scarpa's fascia** of the anterior abdominal wall. - Due to this continuity, urine can actually **track superiorly** into the anterior abdominal wall along this fascial plane. - Therefore, Colle's fascia does NOT prevent spread to the abdomen. *None of the options* - This option is incorrect because Colle's fascia specifically prevents lateral and posterior spread into the ischiorectal fossa through its anatomical attachments.
Question 74: Which lymph nodes are involved in the lymphatic drainage of the lateral wall of the nose?
- A. Deep cervical nodes
- B. Retropharyngeal nodes
- C. Submandibular nodes
- D. All of the options (Correct Answer)
Explanation: ***All of the options*** - The lymphatic drainage from the **lateral wall of the nose** follows a sequential pathway involving **submandibular nodes**, **retropharyngeal nodes**, and ultimately the **deep cervical nodes**. - This question tests understanding of the complete lymphatic drainage pathway, not just the primary drainage site. - All three node groups are anatomically involved in draining lymph from the lateral nasal wall. **Drainage Pathway:** - **Submandibular nodes** (Primary): The anterior and middle portions of the lateral nasal wall drain primarily to the submandibular lymph nodes. - **Retropharyngeal nodes** (Secondary): The posterior portions of the lateral wall and areas near the nasal pharynx drain to retropharyngeal nodes. - **Deep cervical nodes** (Final pathway): Lymph from both submandibular and retropharyngeal nodes eventually drains into the deep cervical chain, particularly the jugulodigastric and juguloomohyoid nodes. *Why not just one node group?* - The lateral wall of the nose has an extensive lymphatic network with multiple drainage routes. - Different regions of the lateral wall have preferential drainage to different node groups. - Understanding the complete drainage pathway is clinically important for assessing spread of infections and malignancies from the nasal cavity.
Question 75: What are the main types of cells found in the cerebellar cortex?
- A. Purkinje cells, granule cells, and molecular layer interneurons (Correct Answer)
- B. Glomus cells
- C. Principal cells
- D. Intercalated cells
Explanation: **Purkinje cells, granule cells, and molecular layer interneurons** - The **cerebellar cortex** is characterized by distinct layers housing these cell types: **Purkinje cells** (large, inhibitory neurons), **granule cells** (small, excitatory neurons), and **molecular layer interneurons** (stellate and basket cells, inhibitory) [1]. - These cells work in concert to process motor information, with Purkinje cells serving as the sole output of the cerebellar cortex [1]. *Glomus cells* - **Glomus cells** are primarily found in the **carotid and aortic bodies**, where they act as chemoreceptors sensing changes in blood oxygen, carbon dioxide, and pH. - They are not a characteristic cell type of the cerebellar cortex. *Principal cells* - **Principal cells** is a general term often used to describe the main excitatory neurons of a brain region, such as **pyramidal cells in the cerebral cortex** or CA3 neurons in the hippocampus [2]. - While granule cells are excitatory in the cerebellum, "principal cells" is not a specific or exclusive term for cerebellar cortical cell types. *Intercalated cells* - **Intercalated cells** are specialized cells found in various locations, such as the **collecting ducts of the kidney** where they regulate acid-base balance, or in the **amygdala** as a type of inhibitory interneuron. - They do not represent a primary cell type of the cerebellar cortex.
Question 76: All are lateral branches of the abdominal aorta, EXCEPT which of the following?
- A. Right testicular artery
- B. Left renal artery
- C. Middle suprarenal artery
- D. Celiac trunk (Correct Answer)
Explanation: ***Celiac trunk*** - The **celiac trunk** is an anterior branch of the abdominal aorta, supplying the foregut derivatives. - It arises from the ventral aspect of the aorta, distinguishing it from lateral branches. *Right testicular artery* - The **testicular arteries** (gonadal arteries) are paired lateral branches of the abdominal aorta. - They arise inferior to the renal arteries and descend to supply the testes in males. *Left renal artery* - The **renal arteries** [1] [3] are large paired lateral branches of the abdominal aorta. - They supply the kidneys [2] and typically arise just inferior to the superior mesenteric artery. *Middle suprarenal artery* - The **middle suprarenal arteries** are paired lateral branches, typically arising directly from the abdominal aorta. - They supply the suprarenal (adrenal) glands [2].
Biochemistry
2 questionsWhat cofactor is required for the proper functioning of glucose-6-phosphate dehydrogenase?
Apoenzyme is ?
NEET-PG 2012 - Biochemistry NEET-PG Practice Questions and MCQs
Question 71: What cofactor is required for the proper functioning of glucose-6-phosphate dehydrogenase?
- A. NAD
- B. NADP (Correct Answer)
- C. FAD
- D. FMN
Explanation: ***NADP*** - **NADP+** (nicotinamide adenine dinucleotide phosphate) acts as the **electron acceptor** in the **glucose-6-phosphate dehydrogenase (G6PD)** reaction, becoming **NADPH**. - **NADPH** is crucial for maintaining the **redox balance** in cells, particularly in red blood cells, by reducing **oxidative stress**. *NAD* - **NAD+** (nicotinamide adenine dinucleotide) is a primary cofactor for many **dehydrogenase reactions** in catabolic pathways like **glycolysis** and the **Krebs cycle**. - It primarily functions as an electron acceptor in pathways that generate **ATP**, distinct from the role of **NADPH** in reductive biosynthesis and antioxidant defense. *FAD* - **FAD** (flavin adenine dinucleotide) is a coenzyme derived from **riboflavin (vitamin B2)** that is involved in various redox reactions, often in the form of **flavoproteins**. - Enzymes like **succinate dehydrogenase** in the electron transport chain utilize **FAD** as an electron acceptor, which is not the case for G6PD. *FMN* - **FMN** (flavin mononucleotide) is another coenzyme derived from **riboflavin**, structurally similar to FAD but lacking the additional adenosine monophosphate. - It participates in electron transfer reactions, particularly within **complex I** of the **electron transport chain**, but is not a cofactor for G6PD.
Question 72: Apoenzyme is ?
- A. Protein moiety (Correct Answer)
- B. Organic cofactor
- C. Inactive enzyme component
- D. Non-protein component required for enzyme activity
Explanation: ***Protein moiety*** - An **apoenzyme** is the **protein component of an enzyme** that is catalytically inactive by itself. - It requires a **non-protein cofactor** (either an inorganic ion or an organic molecule) to become active. *Organic cofactor* - An **organic cofactor** is also known as a **coenzyme**, which binds to the apoenzyme to form a functional holoenzyme. - While essential for enzyme activity, the apoenzyme itself is the protein part, not the organic cofactor. *Inactive enzyme component* - While an apoenzyme is **inactive on its own**, this description is too broad and doesn't specify its chemical nature. - It is specifically the **protein component** that is inactive until bound to its cofactor. *Non-protein component required for enzyme activity* - This describes a **cofactor** (either inorganic or organic), not the apoenzyme itself. - The apoenzyme is the **protein portion**, which *requires* the non-protein component for activity.
Physiology
2 questionsGastric secretions are essential for absorption of -
Which of the following hormones does not mediate its action through cAMP?
NEET-PG 2012 - Physiology NEET-PG Practice Questions and MCQs
Question 71: Gastric secretions are essential for absorption of -
- A. Cobalamin (Correct Answer)
- B. Fat
- C. Thiamine
- D. Folic acid
Explanation: ***Cobalamin*** - **Intrinsic factor**, secreted by gastric parietal cells, is crucial for the absorption of **vitamin B12 (cobalamin)** in the terminal ileum [1]. - Without sufficient intrinsic factor, **pernicious anemia** can develop due to impaired B12 absorption [2]. *Fat* - Fat digestion primarily occurs in the **small intestine** with the help of **bile salts** and **pancreatic lipases**. - While gastric lipase begins some fat digestion, it's not essential for overall fat absorption. *Thiamine* - **Thiamine (vitamin B1)** is absorbed in the jejunum and ileum, primarily via **active transport** and passive diffusion. - Gastric secretions do not play a direct, essential role in its absorption. *Folic acid* - **Folic acid** is absorbed in the **duodenum and jejunum** as monoglutamates after being deconjugated from polyglutamate forms. - This process is not directly dependent on gastric secretions [2].
Question 72: Which of the following hormones does not mediate its action through cAMP?
- A. Glucagon
- B. Follicle stimulating hormone
- C. Estrogen (Correct Answer)
- D. Luteinizing hormone
Explanation: ***Estrogen*** - **Estrogen** is a **steroid hormone** that mediates its action by binding to intracellular receptors, forming a complex that directly influences gene transcription. - Steroid hormones, due to their **lipophilicity**, can cross the cell membrane and do not typically rely on cell surface receptors or second messengers like cAMP. *Glucagon* - **Glucagon** acts on a **G protein-coupled receptor (GPCR)**, specifically a Gs-coupled receptor, leading to the activation of adenylyl cyclase. - This activation increases the intracellular concentration of **cAMP**, which then activates protein kinase A to mediate its effects, primarily on glucose metabolism. *Follicle stimulating hormone* - **FSH** binds to a **GPCR** on target cells, activating the Gs protein pathway. - This activation stimulates **adenylyl cyclase** and increases intracellular **cAMP** levels, which are critical for its role in gamete development. *Luteinizing hormone* - **LH**, like FSH, binds to a cell surface **GPCR** that activates the Gs protein. - This leads to the stimulation of **adenylyl cyclase** and an increase in **cAMP**, mediating its effects on steroidogenesis and ovulation.