Anatomy
3 questionsWhich muscle stabilizes the clavicle during movement of the shoulder?
All are derived from ectoderm except for which of the following?
What anatomical structures are involved in the closure of the fossa ovalis?
NEET-PG 2012 - Anatomy NEET-PG Practice Questions and MCQs
Question 211: Which muscle stabilizes the clavicle during movement of the shoulder?
- A. Pectoralis major
- B. Latissimus dorsi
- C. Subclavius (Correct Answer)
- D. Serratus anterior
Explanation: ***Subclavius*** - The **subclavius muscle** originates from the first rib and inserts into the inferior surface of the clavicle, acting to **depress the clavicle** and prevent its displacement, thus enhancing shoulder stability during movement. - It plays a crucial role in protecting the underlying **neurovascular structures** (brachial plexus and subclavian vessels) from external trauma to the shoulder. *Pectoralis major* - This large, fan-shaped muscle primarily functions in **adduction, medial rotation, and flexion of the humerus** at the shoulder joint [1]. - It does not directly stabilize the clavicle but rather acts on the arm. *Latissimus dorsi* - The **latissimus dorsi** is a broad muscle of the back responsible for **extension, adduction, and internal rotation of the humerus** [1]. - Its actions are mainly on the humerus and it does not directly stabilize the clavicle. *Serratus anterior* - The **serratus anterior** muscle primarily **protracts and rotates the scapula**, keeping it pressed against the thoracic wall. - While it's essential for **scapular stability** and overhead arm movements, it does not directly stabilize the clavicle.
Question 212: All are derived from ectoderm except for which of the following?
- A. Hair follicles
- B. Nails
- C. Lens of the eye
- D. Adrenal cortex (Correct Answer)
Explanation: ***Adrenal cortex*** - The adrenal cortex is derived from the **intermediate mesoderm**, specifically from the cells lining the posterior abdominal wall. The cells migrate to develop into the adrenal cortex. - It produces various steroid hormones, including **aldosterone**, **cortisol**, and **androgens**, which regulate diverse bodily functions. *Lens of the eye* - The lens of the eye is derived from the **surface ectoderm**. It forms from an invagination of the surface ectoderm called the lens placode. - Its primary function is to **focus light** onto the retina. *Hair follicles* - Hair follicles develop from the **surface ectoderm** [1]; they are invaginations of the epidermis that extend into the dermis. - They produce hair, which provides **insulation** and **protection** [1]. *Nails* - Nails are also derivatives of the **surface ectoderm**, forming thickened plates on the dorsal surface of the distal phalanges. - They provide **protection** to the fingertips and aid in grasping objects.
Question 213: What anatomical structures are involved in the closure of the fossa ovalis?
- A. Septum primum + Endocardial cushion
- B. Septum primum + Septum secundum (Correct Answer)
- C. Endocardial cushions + Septum secundum
- D. None of the options
Explanation: The septum primum acts as a valve, closing against the septum secundum postnatally due to changes in atrial pressure. This fusion effectively closes the foramen ovale, leading to the formation of the fossa ovalis. The endocardial cushions are important for the formation of the atrial and ventricular septa, as well as the AV valves, but not directly for the closure of the fossa ovalis. The septum primum is directly involved, but its apposition with the endocardial cushions doesn't close the foramen ovale. While both structures contribute to heart development, their direct interaction is not responsible for the closure of the fossa ovalis. The septum secundum forms the muscular rim of the fossa ovalis, and the endocardial cushions are critical for atrial septation, but not the final closure here. This option is incorrect because the specific combination of septum primum and septum secundum is indeed responsible for the closure of the fossa ovalis.
Biochemistry
5 questionsWhat are digestive enzymes classified as?
Which enzyme is primarily associated with the reduction of NADP+ to NADPH in the pentose phosphate pathway?
What is the specific activity of an enzyme?
What is the classification of the Y chromosome?
Which of the following is required for fatty acid synthesis ?
NEET-PG 2012 - Biochemistry NEET-PG Practice Questions and MCQs
Question 211: What are digestive enzymes classified as?
- A. Hydrolases (Correct Answer)
- B. Oxidoreductases
- C. Transferases
- D. Ligases
Explanation: ***Hydrolases*** - Digestive enzymes like **amylase**, **lipase**, and **proteases** break down complex food molecules by adding water, a process known as **hydrolysis**. - This class of enzymes catalyzes the cleavage of a chemical bond with the concurrent addition of a water molecule. - All major digestive enzymes belong to this class according to the **EC enzyme classification system**. *Oxidoreductases* - These enzymes catalyze **redox reactions**, involving the transfer of electrons from one molecule to another. - Examples include **dehydrogenases** and **oxidases**, which are not primarily involved in breaking down food molecules in digestion. *Transferases* - Transferases catalyze the transfer of functional groups (such as methyl, acyl, or phosphate groups) from one molecule to another. - Examples include **kinases** and **transaminases**, which are involved in metabolic pathways but not in the digestive breakdown of food. *Ligases* - Ligases are enzymes that catalyze the joining of two large molecules by forming a new chemical bond, typically with the concomitant hydrolysis of ATP. - They are involved in **DNA repair** and **biosynthetic reactions**, not in the breakdown of food during digestion.
Question 212: Which enzyme is primarily associated with the reduction of NADP+ to NADPH in the pentose phosphate pathway?
- A. G6PD (Correct Answer)
- B. APDH
- C. α-keto glutarate dehydrogenases
- D. None of the options
Explanation: ***G6PD*** - **Glucose-6-phosphate dehydrogenase (G6PD)** catalyzes the first committed step in the pentose phosphate pathway, converting **glucose-6-phosphate** to **6-phosphogluconolactone**. - This reaction involves the reduction of **NADP+ to NADPH**, making G6PD the primary enzyme for NADPH production in this pathway. *APDH* - **APDH (adenosine phosphosulfate reductase)** is involved in sulfur metabolism and has no direct role in the pentose phosphate pathway or NADPH production. - This enzyme primarily functions in prokaryotes for the **reduction of APS (adenosine 5'-phosphosulfate)**. *α-keto glutarate dehydrogenases* - **Alpha-ketoglutarate dehydrogenase** is a mitochondrial enzyme part of the **Krebs cycle**, converting **alpha-ketoglutarate to succinyl-CoA**. - This enzyme is crucial for ATP production and generates **NADH**, not NADPH, in its reaction. *None of the options* - This option is incorrect because **G6PD** is indeed the primary enzyme responsible for NADPH generation in the pentose phosphate pathway.
Question 213: What is the specific activity of an enzyme?
- A. Enzyme units per mg of protein (Correct Answer)
- B. Concentration of substrate transformed per minute
- C. Enzyme units per mg of substrate
- D. Limit of enzyme per gram of substrate
Explanation: ***Enzyme units per mg of protein*** - **Specific activity** is defined as the number of **enzyme units** (representing catalytic activity) per milligram of total protein in the sample. - It is a measure of **purity**, indicating the amount of active enzyme relative to other proteins in a preparation. - Formula: Specific activity = Units of enzyme activity / mg of total protein - Used to track enzyme purification progress during isolation procedures. *Concentration of substrate transformed per minute* - This describes the **reaction velocity** or rate of catalysis, but not the specific activity of the enzyme. - While related to enzyme activity, it does not normalize the activity to the amount of **total protein**. - This would be expressed as reaction rate or velocity (V), not specific activity. *Enzyme units per mg of substrate* - This is an incorrect formulation that confuses substrate with protein. - **Specific activity** is normalized to the amount of **protein** in the enzyme preparation, not the substrate. - This option represents a common misconception in enzyme kinetics terminology. *Limit of enzyme per gram of substrate* - This phrase does not correspond to any standard biochemical measure of enzyme activity or concentration. - It does not provide information about the **catalytic efficiency** or **purity** of the enzyme preparation. - The term "limit" is not used in the context of specific activity measurements.
Question 214: What is the classification of the Y chromosome?
- A. Metacentric
- B. Submetacentric (Correct Answer)
- C. Acrocentric
- D. None of the options
Explanation: ***Submetacentric*** - The **Y chromosome** is classified as submetacentric because its **centromere** is located off-center, resulting in two arms of unequal length. - The short arm (Yp) is smaller than the long arm (Yq), but not as disproportionate as in acrocentric chromosomes. - The **X chromosome** is also submetacentric, making both sex chromosomes belong to this category. *Metacentric* - A **metacentric chromosome** has its **centromere** located in the middle, resulting in two arms of approximately equal length. - Examples include chromosomes 1, 3, 16, 19, and 20, which have nearly equal arm ratios unlike the Y chromosome. *Acrocentric* - An **acrocentric chromosome** has its **centromere** located very close to one end, creating one very short arm and one very long arm. - The five acrocentric human chromosomes are **13, 14, 15, 21, and 22**, which possess satellite DNA and nucleolar organizing regions (NORs) on their short arms. - The **Y chromosome is NOT acrocentric** despite historical confusion; it has a more centrally positioned centromere than true acrocentric chromosomes. *None of the options* - This option is incorrect because the Y chromosome has a specific and well-established classification as **submetacentric** based on its centromere position and arm ratio.
Question 215: Which of the following is required for fatty acid synthesis ?
- A. NADPH (Correct Answer)
- B. NADH
- C. FADH₂
- D. None of the options
Explanation: ***NADPH*** - **NADPH** is crucial for fatty acid synthesis, providing the **reducing power** needed for the successive reduction steps. - The enzymes involved, such as **fatty acid synthase**, utilize **NADPH** for the conversion of keto groups to hydroxyl groups and then to saturated methylene groups. *NADH* - **NADH** plays a primary role in **oxidative phosphorylation** and the electron transport chain to generate ATP. - It is generally produced during **catabolic reactions** and is not primarily used as a reducing agent in anabolic processes like fatty acid synthesis. *FADH* - **FADH2** (reduced form of FAD, not FADH) is a coenzyme involved in redox reactions, particularly in the **Krebs cycle** and beta-oxidation of fatty acids. - Like NADH, it is mostly involved in **catabolic processes** that generate energy, rather than anabolic processes requiring reducing equivalents for synthesis. *None of the options* - This option is incorrect because **NADPH** is indeed required for fatty acid synthesis, serving as the essential reducing agent. - The other coenzymes mentioned (NADH, FADH) have different metabolic roles, primarily in energy production rather than biosynthesis.
Physiology
2 questionsWhich of the following statements about gastric secretion is true?
Ptyalin is secreted by?
NEET-PG 2012 - Physiology NEET-PG Practice Questions and MCQs
Question 211: Which of the following statements about gastric secretion is true?
- A. Inhibited by curare
- B. Stimulated by nor adrenaline
- C. Increased by stomach distention (Correct Answer)
- D. Stimulated by an increase in tonic activity
Explanation: ***Increased by stomach distention*** - **Stomach distention** activates local reflexes and the **vagovagal reflex**, leading to the release of **acetylcholine** and **gastrin**, which stimulate gastric acid secretion during the gastric phase. - This is a physiological response that prepares the stomach for digestion of incoming food. *Inhibited by curare* - **Curare** is a **nicotinic acetylcholine receptor antagonist** that primarily affects neuromuscular junctions, causing muscle paralysis. - It does not directly inhibit the primary mechanisms of gastric acid secretion, which are largely mediated by **muscarinic acetylcholine receptors**, histamine, and gastrin. *Stimulated by nor adrenaline* - **Noradrenaline** (norepinephrine) is a neurotransmitter of the **sympathetic nervous system**, which generally **inhibits** gastric motility and secretion. - Activation of alpha-2 adrenergic receptors can decrease gastric acid secretion. *Stimulated by an increase in tonic activity* - This statement is vague; "tonic activity" can refer to various physiological processes. If it refers to **sympathetic nervous system** tonic activity, it would **inhibit** gastric secretion. - If it implies increased vagal tone (parasympathetic activity), then secretion would be stimulated, but the phrasing is not precise enough to be unequivocally true for gastric secretion in general.
Question 212: Ptyalin is secreted by?
- A. Gastric gland
- B. Salivary gland (Correct Answer)
- C. Duodenal gland
- D. Pancreatic gland
Explanation: ***Salivary gland*** - **Ptyalin**, also known as **salivary amylase**, is an enzyme produced by the salivary glands. - Its primary role is to initiate the **digestion of carbohydrates** (starches) in the mouth. *Gastric gland* - Gastric glands primarily secrete **hydrochloric acid** and **pepsinogen**, involved in protein digestion. - They do not produce ptyalin or enzymes for carbohydrate digestion. *Duodenal gland* - Duodenal glands (Brunner's glands) secrete alkaline mucus to protect the duodenum from acidic chyme. - They are not involved in the production of carbohydrate-digesting enzymes like ptyalin. *Pancreatic gland* - The pancreas produces **pancreatic amylase**, which continues starch digestion in the small intestine. - While it secretes an amylase, it is distinct from salivary amylase (ptyalin) and released into the duodenum, not the mouth.