FMGE 2017 - Biochemistry PYQs Practice Questions

Q: Colipase is found in?

Pancreatic juice. ***Pancreatic juice*** - **Colipase** is a co-enzyme secreted by the **pancreas** that is essential for the activity of pancreatic lipase. - It helps **pancreatic lipase** anchor to the surface of fat globules, preventing its inactivation by bile salts and facilitating fat digestion. *Saliva* - Saliva primarily contains **alpha-amylase** (ptyalin) for carbohydrate digestion and **lingual lipase** for initial fat digestion. - It does not contain colipase. *Bile* - **Bile** is produced by the liver and stored in the gallbladder, primarily aiding in fat emulsification. - It contains **bile salts**, cholesterol, bilirubin, and phospholipids but not digestive enzymes like colipase. *Succus entericus* - **Succus entericus**, or intestinal juice, is secreted by the small intestine and contains enzymes like **sucrase**, **maltase**, **lactase**, and peptidases. - It does not contain colipase, which is specifically a pancreatic enzyme. [Practice more Biochemistry PYQs on OnCourse]

Q: Which of the following has a polygenic pattern of inheritance?

Diabetes mellitus. **Diabetes mellitus** - **Type 2 Diabetes Mellitus**, the most common form, is a classic example of a **polygenic disease**, meaning it results from the interaction of multiple genes and environmental factors. - Many genes contribute to aspects like **insulin resistance** and **beta-cell dysfunction**, leading to the disease. *Familial hypercholesterolemia* - This condition is inherited in an **autosomal dominant** pattern, primarily due to mutations in a single gene, most commonly the **LDL receptor gene**. - While other genes can influence cholesterol levels, the severe form of familial hypercholesterolemia is typically **monogenic**. *Resistant rickets* - **X-linked hypophosphatemia**, also known as vitamin D-resistant rickets, is inherited in an **X-linked dominant** pattern. - It is caused by mutations in the **PHEX gene**, which affects phosphate reabsorption in the kidneys. *G6PD* - **Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)** is an **X-linked recessive** disorder. - It is caused by mutations in a single gene on the X chromosome, making it a **monogenic** condition. [Practice more Biochemistry PYQs on OnCourse]

Q: Wernicke's encephalopathy is due to deficiency of:

Thiamine. ***Thiamine*** - **Wernicke's encephalopathy** is a serious neurological disorder directly caused by a severe deficiency of **thiamine (vitamin B1)**. - Thiamine is crucial for **glucose metabolism** in the brain; its deficiency impairs energy production, leading to neuronal damage and the characteristic symptoms of confusion, ataxia, and ophthalmoplegia. *B6* - Deficiency of **vitamin B6 (pyridoxine)** can cause peripheral neuropathy, seizures, and microcytic anemia. - It is not the primary cause of the acute neurological syndrome seen in Wernicke's encephalopathy. *B12* - Deficiency of **vitamin B12 (cobalamin)** is associated with megaloblastic anemia and subacute combined degeneration of the spinal cord. - While it can cause neurological symptoms, they differ from the specific triad of Wernicke's encephalopathy. *Niacin* - Deficiency of **niacin (vitamin B3)** causes **pellagra**, characterized by dermatitis, diarrhea, and dementia. - Although it involves neurological symptoms (dementia), the presentation is distinct from Wernicke's encephalopathy. [Practice more Biochemistry PYQs on OnCourse]

Question 1

Vitamin K leads to?

Accepted Answer

γ-carboxylation of glutamic acid residues in clotting factors II, VII, IX, and X

Answer

β-carboxylation of glutamic acid residues in clotting factors II, VII, IX, and X

Answer

α-carboxylation of aspartic acid residues in clotting factors II, VII, IX, and X

Answer

γ-carboxylation of aspartic acid residues in clotting factors II, VII, IX, and X

Question 2

Colipase is found in?

Accepted Answer

Pancreatic juice

Answer

Saliva

Answer

Bile

Answer

Succus entericus

Question 3

Which of the following has a polygenic pattern of inheritance?

Accepted Answer

Diabetes mellitus

Answer

Familial hypercholesterolemia

Answer

Resistant rickets

Answer

G6PD

Question 4

Wernicke's encephalopathy is due to deficiency of:

Accepted Answer

Thiamine

Answer

B6

Answer

B12

Answer

Niacin

FMGE 2017 — Biochemistry