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FMGE 2011 — Biochemistry

Q: Fluoride, used in the collection of blood samples, inhibits which enzyme?

Enolase. ***Enolase*** - Fluoride is a potent inhibitor of **enolase**, an enzyme in the **glycolytic pathway**. - Inhibition of enolase prevents the conversion of **2-phosphoglycerate** to **phosphoenolpyruvate**, thereby halting glycolysis in collected blood samples. *Glucokinase* - Glucokinase is an enzyme primarily found in the **liver** and **pancreatic beta cells** that phosphorylates glucose. - Fluoride does not directly inhibit glucokinase; its primary site of action for preventing glycolysis in blood samples is enolase. *Glucose-6-phosphatase* - This enzyme is crucial for **glucose production** in the liver and kidneys, facilitating the dephosphorylation of **glucose-6-phosphate** to glucose. - Fluoride does not specifically target glucose-6-phosphatase as its mechanism for preventing glycolysis. *Hexokinase* - Hexokinase catalyzes the first step of glycolysis, phosphorylating **glucose to glucose-6-phosphate**. - While essential for glycolysis, hexokinase is not the primary target of fluoride's inhibitory action in blood collection, which specifically aims to stop the entire pathway further downstream at enolase. [Practice more Biochemistry PYQs on OnCourse]

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Fluoride, used in the collection of blood samples, inhibits which enzyme?