Gastric secretion regulation — Flashcards

Flashcard 1: By what mechanisms can H+ secretion still occur in a patient on H2 receptor blockers? _____

Answer: Direct stimulation of parietal cells by vagal stimulation and gastrin stimulation

Flashcard 2: Gastrin increases H+ secretion directly via binding to _____ receptors on parietal cells

Answer: CCKB

Flashcard 3: Gastric HCl secretion during the _____ phase is mediated by both vagal stimulation and direct gastrin release

Answer: gastric

Flashcard 4: Mucus is secreted into the GI tract via _____ cells in the stomach, duodenum, salivary glands, and pancreas

Answer: mucous

Flashcard 5: The _____ phase of gastric HCl secretion accounts for 30% of total HCl secreted

Answer: cephalic

Flashcard 6: Somatostatin decreases gastric acid secretion by decreasing levels of _____ (second messenger)

Answer: cAMP

Flashcard 7: What is the effect of chronic gastritis on gastric HCl secretion? _____

Answer: Decreased (achlorhydria or hypochlorhydria)

Flashcard 8: satiety

Answer: ventromedial area of the hypothalamus

Flashcard 9: What is the function of the area postrema?

Answer: Chemoreceptor trigger zone (CTZ) / Vomiting center

Extra: The area postrema is a circumventricular organ located in the medulla (floor of the 4th ventricle) that lacks a blood-brain barrier, allowing it to detect emetic toxins in the blood.

Flashcard 10: Give two cell types rich in rough endoplasmic reticulum (RER).

Answer: intestinal goblet cells, plasma cells