Antivirals — Flashcards

Flashcard 201: Enfuvirtide targets which step of the HIV life cycle?\n_____

Answer: Fusion

Extra: Enfuvirtide (enfuvir-**tide**) prevents the virus from **t**ying to the cell.

Flashcard 202: HCV therapeutics with the suffix _____ work by inhibiting the NS3/4A protease

Answer: -previr

Flashcard 203: Which type of HAART drug is Maraviroc? _____

Answer: CCR5 antagonist (Entry inhibitor)

Extra: Maraviroc binds to CCR5 on host T cells, inhibiting interaction with viral gp120 and preventing viral entry. Note: Enfuvirtide is the fusion inhibitor (binds gp41).

Flashcard 204: The backbone of Highly active antiretroviral therapy (HAART) are _____ such as Zidovudine

Answer: NRTIs

Flashcard 205: Which polio vaccine is a live attenuated (oral) vaccine? _____

Answer: Sabin

Flashcard 206: Which type of HAART drug is Nevirapine? _____

Answer: NNRTI

Flashcard 207: What drugs can be used to treat Shingles (Herpes zoster)? _____, Valacyclovir

Answer: Famciclovir

Flashcard 208: Drugs with the suffix **-navir** target which enzyme in the HIV life cycle? _____

Answer: HIV protease

Extra: Protease inhibitors prevent maturation of new virions. Ritonavir is a potent inhibitor of cytochrome P450 and is often used to 'boost' the levels of other protease inhibitors.

Flashcard 209: Atazanavir, Darunavir, Lopinavir, Ritonavir What class of antimicrobials are the following drugs? _____

Answer: HIV Protease Inhibitors

Extra: Protease inhibitors (PIs) prevent the cleavage of the Gag-Pol polyprotein, resulting in the production of immature, noninfectious virions.

Flashcard 210: Which poliovirus vaccine is inactivated/killed? _____

Answer: Salk