Antivirals — Flashcards

Flashcard 201: Which group of -cyclovir's is bioactivated by a CMV viral kinase and indicated for treatment of them? _____ Acyclovir, Famciclovir, Valacyclovir OR Ganciclovir, Valganciclovir

Answer: Ganciclovir, Valganciclovir

Flashcard 202: HCV therapeutics with the suffix _____ work by inhibiting the NS3/4A protease

Answer: -previr

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki 

Flashcard 203: Which type of HAART drug is Maraviroc? _____

Answer: CCR5 antagonist (Entry inhibitor)

Extra: Maraviroc binds to CCR5 on host T cells, inhibiting interaction with viral gp120 and preventing viral entry. Note: Enfuvirtide is the fusion inhibitor (binds gp41). Watch Maraviroc, fusion inhibitors, integrase inhibitors: https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-antimicrobials/videos/medical-pharmacology-antimicrobials-antivirals-hiv-maraviroc-fusion-inhibitors-integrase-inhibitors

Flashcard 204: The backbone of Highly active antiretroviral therapy (HAART) are _____ such as Zidovudine

Answer: NRTIs

Extra:    https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 205: Which polio vaccine is a live attenuated (oral) vaccine? _____

Answer: Sabin

Extra:   https://onlinemeded.org/spa/pediatrics/vaccinations/acquire?ref=anki 

Flashcard 206: Which type of HAART drug is Nevirapine? _____

Answer: NNRTI

Extra:  Watch NNRTIs [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-antimicrobials/videos/medical-pharmacology-antimicrobials-antivirals-hiv-nnrtis?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki 

Flashcard 207: What drugs can be used to treat Shingles (Herpes zoster)? _____, Valacyclovir

Answer: Famciclovir

Extra:   Watch Varicella zoster virus (Herpesviridae) [https://dashboard.sketchy.com/study/medical/courses/medical-microbiology/units/medical-microbiology-viruses/videos/medical-microbiology-viruses-dna-viruses-varicella-zoster-virus-herpesviridae?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/dermatology/videos/infectious-diseases-of-the-skin?index=4] https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki 

Flashcard 208: Drugs with the suffix **-navir** target which enzyme in the HIV life cycle? _____

Answer: HIV protease

Extra: Protease inhibitors prevent maturation of new virions. Ritonavir is a potent inhibitor of cytochrome P450 and is often used to 'boost' the levels of other protease inhibitors.

Flashcard 209: Atazanavir, Darunavir, Lopinavir, Ritonavir What class of antimicrobials are the following drugs? _____

Answer: HIV Protease Inhibitors

Extra: Protease inhibitors (PIs) prevent the cleavage of the Gag-Pol polyprotein, resulting in the production of immature, noninfectious virions.

Flashcard 210: Which poliovirus vaccine is inactivated/killed? _____

Answer: Salk

Extra:   Watch Poliovirus (PicoRNAviridae) [https://dashboard.sketchy.com/study/medical/courses/medical-microbiology/units/medical-microbiology-viruses/videos/medical-microbiology-viruses-rna-viruses-positive-sense-poliovirus-picornaviridae?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/immunology/videos/vaccinations?index=6] https://onlinemeded.org/spa/pediatrics/vaccinations/acquire?ref=anki