Antifungals — Flashcards

Flashcard 71: What class of antifungals prolong the QT interval? _____

Answer: Azoles

Flashcard 72: The antifungal class allylamines can be recognized via the suffix _____

Answer: -fine (e.g. terbinafine)

Flashcard 73: Which antifungal works by disrupting mitotic spindles? _____

Answer: Griseofulvin

Flashcard 74: Griseofulvin inhibits the function of _____, resulting in metaphase arrest of cellular division

Answer: microtubules

Flashcard 75: Oral candidiasis (thrush) can be treated with _____ ("swish and swallow")

Answer: Nystatin

Extra: Nystatin is a polyene antifungal. Mechanism: Binds to ergosterol, forming pores in the fungal cell membrane that allow leakage of electrolytes. Clinical use: Oral candidiasis (thrush), topical for diaper rash or vaginal candidiasis. Too toxic for systemic use.

Flashcard 76: Griseofulvin _____ cytochrome P-450

Answer: induces

Flashcard 77: Systemic (disseminated) infections of coccidioidomycosis are treated with _____

Answer: Amphotericin B

Flashcard 78: What are the two topical azoles? _____

Answer: Clotrimazole; Miconazole

Flashcard 79: Which oral azole is used in the treatment of mucocutaneous candidiasis? _____

Answer: Fluconazole

Flashcard 80: Ketoconazole has anti-androgenic effects and thus can cause _____ in males

Answer: gynecomastia