Antifungals — Flashcards

Flashcard 11: _____ is a drug that inhibits glucocorticoid biosynthesis via inhibition of the enzyme cholesterol desmolase

Answer: Ketoconazole

Flashcard 12: What is the mainstay treatment for dermatophytes/Tinea infections? _____

Answer: Topical -azoles (clotrimazole)

Flashcard 13: Flucytosine has significant _____ toxicity

Answer: bone marrow

Flashcard 14: What is the treatment for local histoplasmosis, blastomycosis, and coccidioidomycosis infections? _____

Answer: Itraconazole

Flashcard 15: What class of antimicrobials are **caspofungin**, **micafungin**, and **anidulafungin**? _____

Answer: Echinocandins

Extra: Echinocandins (e.g., caspofungin, micafungin, anidulafungin) inhibit cell wall synthesis by inhibiting synthesis of **β(1,3)-D-glucan**.

Flashcard 16: Echinocandins are administered _____ for systemic candidiasis

Answer: IV

Flashcard 17: The oral antifungal drug _____ is used to treat onychomycosis (dermatophyte infection of nails)

Answer: Terbinafine

Flashcard 18: The risk of oropharyngeal candidiasis following inhaled corticosteroids is reduced by _____ after each treatment

Answer: gargling water and spitting

Extra: Sketchy Pharmacology: Respiratory (Asthma)

Flashcard 19: What is the first-line treatment for thrush (oral candidiasis)? _____

Answer: Nystatin

Flashcard 20: Systemic (disseminated) infections of Blastomycosis are treated with _____

Answer: Amphotericin B