Targeted therapies (kinase inhibitors) — Flashcards

Flashcard 1: Erlotinib is a first-line treatment of _____ cancer

Answer: non-small cell lung

Flashcard 2: Cetuximab is an antitumor monoclonal antibody that targets _____

Answer: EGFR

Flashcard 3: Imatinib specifically inhibits the Bcr-Abl fusion protein by blocking the _____ portion

Answer: ATP-binding site of the Abl tyrosine kinase (Abl portion)

Flashcard 4: Erlotinib therapy is associated with _____ and diarrhea (adverse effects)

Answer: acneiform skin rash

Flashcard 5: Imatinib is a _____ inhibitor of the Bcr-Abl fusion protein

Answer: competitive

Flashcard 6: Imatinib is a small molecule _____ inhibitor

Answer: tyrosine kinase

Flashcard 7: Sorafenib and Sunitinib inhibit the _____ RTK

Answer: VEGF receptor (VEGFR)

Flashcard 8: Mechanism and indication of Anastrozole?

Answer: Aromatase inhibitor used in postmenopausal breast cancer

Extra: Mechanism: Competitively inhibits aromatase, decreasing estrogen synthesis. Indication: ER-positive breast cancer in postmenopausal women. Examples of other aromatase inhibitors: Letrozole, Exemestane.

Flashcard 9: Mechanism of action of Exemestane:

Answer: Irreversible (Steroidal) Aromatase Inhibitor

Extra: Mechanism: Irreversible inhibition of the enzyme aromatase. Indication: Breast cancer in postmenopausal women. Note: Exemestane is a steroidal inhibitor, unlike Anastrozole and Letrozole which are non-steroidal (reversible).

Flashcard 10: alkylating agents

Answer: absence of digits (and multiple varied anomalies)