Proteasome inhibitors — Flashcards

Flashcard 1: Which HAART drugs prevent mature virion formation from large polypeptides?_____

Answer: Protease inhibitors

Flashcard 2: What suffix is associated with small molecule kinase inhibitors?_____

Answer: -nib

Flashcard 3: _____ inhibitors inhibit the enzyme responsible for cleaving proteins during viral replication

Answer: Protease

Flashcard 4: One adverse effect of proton pump inhibitors (PPIs) is increased risk for _____ infection (2-3x increased risk)

Answer: Clostridium difficile

Flashcard 5: Proteasomal inhibitors work best in cancers that mark _____ proteins to be targeted for degradation too quickly

Answer: pro-apoptotic

Flashcard 6: Imatinib is a _____ inhibitor of the Bcr-Abl fusion protein

Answer: competitive

Flashcard 7: Which hepatitis drug has myelosuppression as a possible side effect?_____

Answer: Interferon alpha

Flashcard 8: Mechanism and indication of Anastrozole?

Answer: Aromatase inhibitor used in postmenopausal breast cancer

Extra: Mechanism: Competitively inhibits aromatase, decreasing estrogen synthesis. Indication: ER-positive breast cancer in postmenopausal women. Examples of other aromatase inhibitors: Letrozole, Exemestane.

Flashcard 9: Mechanism of action of Exemestane:

Answer: Irreversible (Steroidal) Aromatase Inhibitor

Extra: Mechanism: Irreversible inhibition of the enzyme aromatase. Indication: Breast cancer in postmenopausal women. Note: Exemestane is a steroidal inhibitor, unlike Anastrozole and Letrozole which are non-steroidal (reversible).

Flashcard 10: alkylating agents

Answer: absence of digits (and multiple varied anomalies)