Monoclonal antibodies in cancer — Flashcards

Flashcard 1: Which antitumor monoclonal antibody targets vascular endothelial growth factor?_____

Answer: bevacizumab

Flashcard 2: Cetuximab is an antitumor monoclonal antibody that targets _____

Answer: EGFR

Flashcard 3: Rituximab is a chimeric, monoclonal, Ig_____ antibody

Answer: G

Flashcard 4: Which antitumor monoclonal antibody targets epidermal growth factor receptor?_____

Answer: Cetuximab

Flashcard 5: Which antitumor monoclonal antibody is associated with heart failure (cardiotoxicity)?_____

Answer: trastuzumab (herceptin)

Flashcard 6: Which antitumor monoclonal antibody has an increased risk of bleeding and thromboembolism?_____

Answer: bevacizumab

Flashcard 7: Nivolumab is an anti-checkpoint monoclonal antibody that binds to _____ on T cells.

Answer: PD-1

Flashcard 8: Mechanism and indication of Anastrozole?

Answer: Aromatase inhibitor used in postmenopausal breast cancer

Extra: Mechanism: Competitively inhibits aromatase, decreasing estrogen synthesis. Indication: ER-positive breast cancer in postmenopausal women. Examples of other aromatase inhibitors: Letrozole, Exemestane.

Flashcard 9: Mechanism of action of Exemestane:

Answer: Irreversible (Steroidal) Aromatase Inhibitor

Extra: Mechanism: Irreversible inhibition of the enzyme aromatase. Indication: Breast cancer in postmenopausal women. Note: Exemestane is a steroidal inhibitor, unlike Anastrozole and Letrozole which are non-steroidal (reversible).

Flashcard 10: alkylating agents

Answer: absence of digits (and multiple varied anomalies)