Hormonal therapies — Flashcards

Flashcard 1: Tamoxifen is used to treat and prevent recurrence of _____ positive breast cancer

Answer: ER/PR

Flashcard 2: Ethinyl estradiol, DES, and mestranol are examples _____ analogs

Answer: estrogen

Flashcard 3: Flutamide is used for _____ carcinoma

Answer: prostate

Flashcard 4: Tamoxifen increases the risk of thromboembolic events and _____ cancer

Answer: endometrial

Flashcard 5: Leuprolide is a GnRH analog with _____ properties when used in a continuous fashion

Answer: antagonist

Flashcard 6: What drug class do anastrozole and letrozole belong to?_____

Answer: Aromatase inhibitors

Flashcard 7: Leuprolide is a _____ analog

Answer: GnRH

Flashcard 8: Leuprolide is a GnRH analog with _____ properties when used in a pulsatile fashion

Answer: agonist

Flashcard 9: Mechanism and indication of Anastrozole?

Answer: Aromatase inhibitor used in postmenopausal breast cancer

Extra: Mechanism: Competitively inhibits aromatase, decreasing estrogen synthesis. Indication: ER-positive breast cancer in postmenopausal women. Examples of other aromatase inhibitors: Letrozole, Exemestane.

Flashcard 10: Mechanism of action of Exemestane:

Answer: Irreversible (Steroidal) Aromatase Inhibitor

Extra: Mechanism: Irreversible inhibition of the enzyme aromatase. Indication: Breast cancer in postmenopausal women. Note: Exemestane is a steroidal inhibitor, unlike Anastrozole and Letrozole which are non-steroidal (reversible).