Antimetabolites — Flashcards

Flashcard 1: One cause of folate deficiency is _____, such as folate antagonists

Answer: drugs

Flashcard 2: 6-mercaptopurine is used to treat _____ malignancies

Answer: hematologic (ie: ALL)

Flashcard 3: What vitamin deficiency results from methotrexate use?_____

Answer: Folate (B9)

Flashcard 4: What prodrug is metabolized to 6-mercaptopurine and thus inhibits de novo purine synthesis?_____

Answer: Azathioprine

Flashcard 5: Which DNA polymerase inhibiting pyrimidine analog is used to treat both hematologic malignancies and solid tumors?_____

Answer: Gemcitabine

Flashcard 6: Which of the antimetabolite chemo drugs can cause neurotoxicity?_____

Answer: Cladribine

Flashcard 7: Cladribine is a cytotoxic _____ analog

Answer: purine

Flashcard 8: Mechanism and indication of Anastrozole?

Answer: Aromatase inhibitor used in postmenopausal breast cancer

Extra: Mechanism: Competitively inhibits aromatase, decreasing estrogen synthesis. Indication: ER-positive breast cancer in postmenopausal women. Examples of other aromatase inhibitors: Letrozole, Exemestane.

Flashcard 9: Mechanism of action of Exemestane:

Answer: Irreversible (Steroidal) Aromatase Inhibitor

Extra: Mechanism: Irreversible inhibition of the enzyme aromatase. Indication: Breast cancer in postmenopausal women. Note: Exemestane is a steroidal inhibitor, unlike Anastrozole and Letrozole which are non-steroidal (reversible).

Flashcard 10: alkylating agents

Answer: absence of digits (and multiple varied anomalies)