Inflammation — Flashcards

Flashcard 191: What type of hypersensitivity reaction is SLE? _____

Answer: Type III* HSR (immune complex deposition)

Flashcard 192: Pathogenesis of asthma involves allergens inducing a TH_____ phenotype in CD4+ T cells of genetically susceptible individuals

Answer: 2

Flashcard 193: The gross appearance of inflammatory breast cancer is often described as resembling an _____ (due to invasion of lymphatic spaces)

Answer: orange peel (Peau d'orange)

Flashcard 194: SCID is characterized by absent _____ on flow cytometry

Answer: T cells

Flashcard 195: What type of hypersensitivity reaction is Goodpasture syndrome? _____

Answer: Type II HSR

Flashcard 196: What type of hypersensitivity reaction is rheumatic fever? _____

Answer: Type II HSR (inflammation)

Flashcard 197: Which type of transplant rejection occurs within minutes? _____

Answer: Hyperacute

Flashcard 198: What type of hypersensitivity reaction is Pernicious anemia? _____

Answer: Type II HSR

Extra: Pernicious anemia is a **Type II hypersensitivity reaction** characterized by the production of autoantibodies against: 1. **Gastric parietal cells** (specifically the H+/K+ ATPase pump) 2. **Intrinsic Factor (IF)** These antibodies interfere with vitamin B12 absorption, leading to megaloblastic anemia. While T-cell mediated (Type IV) destruction of parietal cells contributes to the underlying chronic atrophic gastritis, medical boards classically categorize Pernicious Anemia as Type II.

Flashcard 199: Are acute phase reactants produced by liver in acute or chronic inflammatory states?_____

Answer: Both

Flashcard 200: What microscopic changes occur from 1 - 3 days post-MI? _____

Answer: Neutrophils (acute inflammation)