Inflammation — Flashcards

Flashcard 191: _____ leprosy is unable to be contained within macrophages, allowing for diffuse inflammatory damage

Answer: Lepromatous

Flashcard 192: What type of hypersensitivity reaction is rheumatic fever? _____

Answer: Type II HSR (inflammation)

Flashcard 193: What type of hypersensitivity reaction is Pernicious anemia? _____

Answer: Type II HSR

Extra: Pernicious anemia is a **Type II hypersensitivity reaction** characterized by the production of autoantibodies against: 1. **Gastric parietal cells** (specifically the H+/K+ ATPase pump) 2. **Intrinsic Factor (IF)** These antibodies interfere with vitamin B12 absorption, leading to megaloblastic anemia. While T-cell mediated (Type IV) destruction of parietal cells contributes to the underlying chronic atrophic gastritis, medical boards classically categorize Pernicious Anemia as Type II.

Flashcard 194: Which type of transplant rejection occurs within minutes? _____

Answer: Hyperacute

Flashcard 195: Pathogenesis of asthma involves allergens inducing a TH_____ phenotype in CD4+ T cells of genetically susceptible individuals

Answer: 2

Flashcard 196: What type of hypersensitivity reaction is Goodpasture syndrome? _____

Answer: Type II HSR

Flashcard 197: The gross appearance of inflammatory breast cancer is often described as resembling an _____ (due to invasion of lymphatic spaces)

Answer: orange peel (Peau d'orange)

Flashcard 198: SCID is characterized by absent _____ on flow cytometry

Answer: T cells

Flashcard 199: Which cytokine is responsible for maintaining granulomas in TB infection? _____

Answer: TNF-α (from macrophages)

Flashcard 200: Transudate is characterized by _____ LDH compared to serum

Answer: decreased